Estrogens against skin aging: the main effects of HRT

As the processes that contribute to skin aging relentlessly affect everyone, researchers are increasingly looking to use newly acquired knowledge to develop effective anti-aging treatments.

Estrogen receptors are found in almost every tissue of the body and affect the functions of all organ systems in a woman. This is especially true of the largest organ, the skin.

Women's skin due to the lack of estrogen associated with menopause, it ages at an accelerated rate compared to men's, with both structural and functional deterioration of the skin condition observed.

On estet-portal.com, read what role slows down the aging of women's skin plays hormone replacement therapy.

• Estrogens against skin aging: the main effects of HRT
• The mechanism of the effect of estrogen replacement therapy on agingthick skin

Estrogens against skin aging: the main effects of HRT

Systemic estrogen replacement therapy (HRT), has been shown to lead to dramatic changes in skin aging.

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Estrogen therapy reverses the thinning of aging skin by:

• increased collagen synthesis;
• slow down collagen degradation;
• wrinkle reduction;
• activation of the synthesis of type III collagen and hyaluronic acid;
• increase skin hydration;
• Improve the protective properties of the skin.

Despite the well-documented benefits of HRT for aging skin, concerns about the safety of long-term use of estrogen for other organs limit the use of hormone therapy with estrogen.

Read also: Estrogens on the alert: female sex hormones against aging

 

 

 

 

In some studies, hormone replacement therapy has been associated with an increased risk of cardiovascular disease.

Ongoing research indicates that appropriate timing of estrogen replacement therapy may be the key to maximizing efficacy while minimizing associated risks.

New approaches are currently being explored, including the use of topical estrogens, phytoestrogens, and tissue-specific drugs called selective estrogen receptor modulators, whichmay be useful in maintaining optimal health skin in the postmenopausal period.

Mechanism of the effect of estrogen replacement therapy on aging skin

Estrogen replacement therapy recreates the "biochemical portrait" of young skin and therefore is the most promising basis for future treatments aimed at reversing or slowing down skin aging.

Read also: How the level of female hormones changes with obesity

Women have significantly more estrogen receptors than men, and these receptors are found in virtually all female tissues.

Estrogens and other sex hormones have a significant impact on the biology and structure of the skin, affecting:

• epidermal keratinocytes;
• dermal fibroblasts;
• melanocytes;
• hair follicles;
• sebaceous glands.

In fact, threshold levels of estrogen are believed to be critical for maintaining skin integrity.

 

High estrogen levels are associated with increased skin thickness.

Skin aging can be significantly slowed by estrogen administration at menopause; in addition, almost every structural and functional change that accompanies menopause in women has been shown to be at least partially reversible with estrogen hormone replacement therapy.

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