Atopic dermatitis – a disease that is accompanied by severe discomfort – dry skin and itching.
Affecting almost 20% of children, this disease becomes a headache for thousands of parents.
Atopic dermatitis is difficult to control, so the condition has a negative impact on quality of life.
Research shows that genetics play an important role in the development of atopic dermatitis.
It is genetic characteristics that cause a violation of the integrity of the skin, as a result of which environmental allergens more easily penetrate the dermis and provoke the immune system.
Read more about the regulation of inflammatory processes in atopic dermatitis at estet-portal.com in this article.
- How does the immune system react to allergens in atopic dermatitis
- Mast cell-neuron interactions at the heart of atopic dermatitista
How does the immune system react to allergens in atopic dermatitis
How our immune system reacts to allergens in atopic dermatitis is not fully known. Therefore, a group of young researchers "IMMCEPTION" is engaged in this issue. led by Nicolas Gaudenzio.
They are studying how the human immune system interacts with sensory neurons to understand the regulation of inflammation in atopic dermatitis.
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In patients with atopic dermatitis, there is a huge amount of neuropeptides in the blood, namely chemical messengers.
At the same time, the more of these compounds circulating in the body, the more severe the severity of atopic dermatitis.
Read also: How to get rid of seborrheic dermatitis: effective treatments
The appearance of neuropeptides indicates that sensory neurons have been activated, which means that the patient's skin has come into contact with the allergen.
These patients also have a number of enzymes in their blood that indicate the presence of mast cellsok.
Mast cells – these are skin immune cells that play an important role in modulating inflammatory and allergic processes.
Mast cell-neuron interactions at the heart of atopic dermatitis
Having followed these phenomena, the team of scientists began to study the interaction of sensory neurons and mast cells in more detail.
In a model of atopic dermatitis, the researchers found that under the skin of mice with signs of inflammatory reactions, there is a cluster of mast cells and sensory neurons that stick together.
Read also: Effective treatment of atopic dermatitis: modern methods
The researchers then showed that when mice were exposed to dust mites, these "sensory neuroimmune units" were able to detect the presence of these allergens, causing allergic inflammation.
In the longer term, this discovery may have practical therapeutic implications.
Because scientists will now start looking for substances that can block the interaction between mast cells and sensory neurons that triggers the inflammatory response in atopic dermatitis.
One of the questions that scientists are now looking to answer is what these "sensory neuroimmune units" are for.
They should be protective as they are also found in healthy people.
Read also: Effective treatment of atopic dermatitis: modern methods
But it may happen that these units do not work properly in people with atopic dermatitis.
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