Роль цинка в препаратах эстетической медицины: почему он так важен

Zinc performs catalytic, structural or regulatory functions in more than 300 metalloenzymes that are involved in nucleic acid and protein metabolism and energy production.

Low serum zinc is usually accompanied by bullous ulcers, pemphigoid and pressure sores. In addition, a genetic inability to absorb zinc from the intestine leads to enteropathic actodermatitis.

The article estet-portal.com will reveal all the known functions of zinc, and confirm the need for its use in the form of food additives and topical agents in cosmetology.

The role of zinc in the functioning of skin cells

•    Zinc and immune functions
Zinc provides a peripheral pool of T-lymphocytes, cytotoxic activity of T-lymphocytes, T-helper lymphocytic function, natural killer cell activity, macrophage, neurophilic function and antibody production.

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Some of these effects can be explained by the membrane stabilizing effect of the ion. Zinc can also influence gene expression by activating various immunological transcription factors. Zinc induces the production of cytokines including IL-1, IL-6 and tumor necrosis factor-? (TNF-.alpha.).

•    Zinc and the redox system
Zinc may have secondary antioxidant activity, but does not have redox activity under physiological conditions. It can influence the structure of the membrane due to its ability to stabilize thiol groups and phospholipids.

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The role of zinc in wound repair and healing

Zinc and zinc-containing proteins are involved in almost all stages of wound healing; it plays a significant role in activating cell migration and protein synthesis.

The role of zinc in the treatment of diffuse alopecia

Specific metalloproteinases are secreted by keratinocytes, fibroblasts and other cells in response to local growth factor signals. This response is the driving force behind tissue remodeling and facilitates the movement of new cells into the wound. Matrix degradation is mediated by metalloproteinases that specifically cleave matrix proteins such as collagen, elastin, laminin, vitronectin and fibronectin.

Zinc concentrations in the epidermis (50-70 µg/g dw) are higher than in the dermis (10-5 µg/g dw), possibly reflecting the activity of zinc-dependent RNA and DNA polymerases in mitotic active basal cells. cells.

Transcription factors containing zinc (Bazonuclean and c-Krox) interact with DNA and RNA polymerases to initiate the transcription of genes involved in wound healing. Basonuklin is responsible for cell division. The transcription factor c-Krox coordinates the expression of two type I collagen genes in the skin and fibronectin.

The synthesis of both collagen and fibronectin plays a central role in wound healing.

Effects of using topical products containing zinc

•    Zinc inhibits the degranulation of mast cells, thereby reducing the secretion of histamine, which is an auxiliary mediator of the inflammatory response and an itch stimulator.

•    Another effect of zinc is its ability to inhibit the formation of nitric oxide (NO), which can interact with superoxide anion (02) and form peroxynitrite (ONOO); last – a cytotoxic agent that causes tissue damage and inflammation of the skin. Zinc may inhibit NO production by decreasing iNOS expression and/or inhibiting the activity of calmodulin, which is a subunit component of iNOS.

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•    Zinc has been shown to reduce cellular and genetic alteration caused by ultraviolet light exposure and increase the resistance of skin fibroblasts to oxidative stress.

•    Zinc can displace other, more harmful, redox metals such as iron and copper, which can cause oxygen-based free radicals to form.

Thus, the use of preparations containing zinc in the form of dietary supplements and topical methods is justified due to the many effects that zinc has in the body and in the skin in particular.

Thank you for staying with estet-portal.com. Read other interesting articles in the "Cosmetology" section. You may be interested in Nutraceuticals in the fight for youthful skin and body health

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