В помощь косметологу: практические аспекты применения ботулотоксина

In the world of aesthetic medicine, botulinum therapy is very popular today – a direction that deals with the theoretical and practical aspects of the use of botulinum toxin preparations. The safety of the procedure for the introduction of botulinum toxin when using high-quality registered drugs and the correct manipulation is proven in the course of numerous scientific studies. The rapid and effective correction of age-related changes with botulinum toxin preparations has made botulinum therapy popular among women and men around the world. Read about how to properly store and restore botulinum toxin preparations on estet-portal.com in this article.

Why botulinum toxin is an effective means of correcting age-related changes

Botulinum toxin – the world's strongest toxic substance of organic origin, which is produced by the bacteria Clostridium botulinum. Being the central link in the pathogenesis of botulism – botulinum toxin is successfully used today in the neurological, gastroenterological and cosmetological fields of medicine. For the first time, the botulinum toxin preparation as a therapeutic agent was used in ophthalmological practice back in 1978. 

The action of botulinum toxin, both therapeutic and toxic, is associated with its ability to inhibit the release of acetylcholine into the synaptic cleft, which leads to a violation of the neuromuscular innervation, and, as a result, muscle relaxation.

Knowledge of aspects of the practical application of botulinum toxin preparations is relevant for dermatologists, cosmetologists, neuropathologists and gastroenterologists. In this article, we will look at how to avoid loss of effectiveness when restoring botulinum toxin preparations and what every doctor needs to know about storing them.

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How to avoid loss of effectiveness when restoring botulinum toxin preparations

Proper recovery of botulinum toxin preparations is the most important step in its practical application. It is well known that initially botulinum toxin in the vial is in the form of an amorphous powder. In order to convert it into a form suitable for intradermal administration, the contents of the vial must be mixed with a solvent. The universal solvent that is suitable for botulinum toxin reconstitution is sterile saline.

Before reconstituting the drug, the vial cap must be wiped with an antiseptic solution, and it is forbidden to open the vial – this can lead to a loss of effectiveness of the substance. An interesting fact: in the course of studies conducted in the USA on botulinum toxin, it was proved that the intensity of shaking the contents of the vial does not affect the effectiveness of subsequent botulinum therapy. 

Storage of botulinum toxin preparations: what every doctor needs to know

The rules for storing botulinum toxin preparations depend on its manufacturer and must be implemented in accordance with the instructions for use – this is a well known statement. But in his practice, a cosmetologist also has to deal with the need to store already reconstituted preparations, and this aspect is still a controversial issue in the practical use of botulinum toxin. 

A large number of studies have been conducted on how long it is possible to store botulinum toxin without losing its muscle relaxant properties, but the results of their – are ambiguous and contradictory. 

Therefore, it is not recommended to store the drug for no longer than 4 hours. This term was the minimum period of time in which the preservation of the properties of botulinum toxin was proven in the course of research.

Thank you for staying with estet-portal.com. Read other interesting articles on the site in the "Cosmetology" section. You may also be interested in: The effectiveness of botulinum toxin preparations: why the degree of purification of the substance is important

 

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