Facial Aging – the result of internal and external changes that overlap each other and are associated with the formation of a large number of free radicals that provoke dysfunction or cell death and degradation of the extracellular matrix.
The clinical manifestations of chronological aging occur when tissue damage exceeds its regeneration capacity.
How adipose tissue stem cell injections help modern estheticians fight the signs of facial aging, in this article estet-portal.
- Autologous Adipose Stem Cell Injections for Facial Rejuvenation
- a
- Signs of facial aging and age-related changes All proliferating and differentiated cells are subject to processes of internal aging which manifest themselves as the following signs: skin thins and becomes translucent;
pigmentation disorders (hypo- or hyperpigmentation), telangiectasia appear;
there is atrophy of bone, cartilage and muscle structures; there is a loss of subcutaneous fat volumes, its redistribution and shift to the lower third of the face.
- Totally, the changes described above lead to deformation of the facial contour
- , which include:
- sunken cheeks;
- sunken eye sockets;
flattened forehead and temples; eyebrow and eyelid ptosis;
- drooping of the tip of the nose;
- chin retraction;
- atrophy of the earlobes and lips;
- Irregular contours lower face.
- Atrophy
- and sagging of the skin are the result of weakened support, reduced skin elasticity and gravity. Dynamic and static wrinkles, lines, folds and furrows appear on the skin. In addition, shadows cast by protruding structures can also give a tired look to the face.
Fig. 1:
and (photo 
.Dimitra Dasiou) Injections of autologous adipose tissue stem cells for facial rejuvenation Apoptosis and cell aging – important factors in facial aging in general. In the process of regeneration, dead cells are replaced by new ones that develop from stem cells. Unfortunately, with age, their number and ability to proliferate decrease. Loss of volumes – an important component of the facial aging process, which can be corrected by injections of autologous adipose tissue stem cells.
Traditionally, dermatologists and estheticianscombine various methods
to eliminate the visible signs of facial skin aging. However, the results obtained must be constantly supported by additional procedures.Chronological aging can be slowed down through local stem cell replacement.
Middle Facial Contour in Young Patients: Filler Selection for Natural Results
have great potential for differentiation in various directions;
their amount (per gram of processed adipose tissue) is significantly higher than in the bone marrow; they are easy to get.
From 300 ml of lipoaspirate, 1x107 adipose tissue stromal cells are usually obtained with a purity of more than 95%, which on average account for 2% of all nuclear cells.
Autologous adipose tissue stem cells are harvested during- minimal invasive liposuction
- under tumescent anesthesia from the abdomen or inner thigh.
- Received lipoaspirate
- is processed according to the final purpose of administration:
viable cells (adipocytes and stromal fat fraction/adipose tissue stem cells) are needed to restore volume; Skin regeneration requires fluid with growth factors and cytokines released from destroyed adipocytes and other cellular components of the stromal fat fraction.
The viability of adipocytes, pericytes and adipose tissue stem cells – the key to successful volume recovery, and therefore must be handled with great care. In addition, it is very important to choose the right cannulas for the collection and administration of the material.
Lipofilling: new opportunities for dermatocosmetologists
- Successful engraftment of adipocytes and effective skin regeneration are achieved by superficial (subcutaneous) injections of small clusters of adipose tissue (0.2 mm & ndash; 0.8 mm) in a linear fan technique.
- This maximizes contact surface area, blood supply, and fat graft survival.
Large volumes of transplanted fat
are subject to central necrosis, loss of volume, and may induce the formation of cysts with fatty contents.As a result of exposure to an oxygen-free environment, most of the adipocytes collected during liposuction die, only10% of fat cells survive
.After the injection of lipoaspirate into the facial area, pericytes from the stromal fat fraction are activated and transformed into adipose tissue stem cells. In turn, stem cells begin to secrete a heterogeneous spectrum of growth factors and cytokines that have a paracrine effect and activate the proliferation of progenitor cells of all three germ layers, including preadipocytes that develop into mature adipocytes and provide volume restoration.
Technical aspects and perspectives of the lipofilling technique
Thus,
stem cells are important not only for volume restoration, but also for adipocyte engraftment and skin repair.
During the first three months after the administration of adipocytes and stromal fat fraction/stem cells of adipose tissue,resorption of up to 50% of the injected volume
is observed. Therefore, to ensure a long-term aesthetic result, two or more additional procedures are necessary.Follow us on Instagram
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From an aesthetic point of view, adipose tissue stem cells provide satisfactory long-term results and may be able to replace combined cosmetic procedures, which must be performed regularly to obtain comparable results.Based on magazine
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