Contour correction with new generation fillers

Contouring with Fillers − a real revolution in the world of cosmetology!

With these safe and effective procedures, physicians can now do what was previously only possible for surgeons.

Aesthetic medicine is constantly evolving and improving. And while this is happening, cosmetologists are struggling to find the perfect filler that would solve all age-related problems, maintain the effect for a long time and at the same time − was absolutely safe.

Find out in the article on estet-portal.com about the results of clinical studies on the effectiveness and safety of fillers based on carboxymethyl cellulose.

• Disadvantages of modern fillers for facial contouring
• Studying the effectiveness of new drugs for facial contouring
• Rheological properties and capabilities of Erell fillerse

Disadvantages of modern fillers for facial contouring

Currently, aesthetic medicine is experiencing real scientific progress, and injectable wrinkle correction techniques are more the norm than isolated cases.

Follow us on Instagram!

And although at the moment there is no more studied molecule than hyaluronic acid, the rapid metabolism of the filler, as well as the delayed-type sensitivity reactions, which are increasingly being recorded, fibrotic changes in tissues have led to the fact that specialists in areas of aesthetic medicine are constantly in search of those components that can level these adverse reactions of the use of hyaluronic acid fillers to correct age-related changes.

Effective approaches to volume restoration in the middle third of the face

An innovative molecule that is a safe alternative to HA most commonly used for contouring is the recently discovered carboxymethyl cellulose.

It is a biosynthetic substance that is used as a thickener or viscosity modifier in cosmetics.

Carboxymethylcellulose is a ballast substance, which is completely physiologically inert, which is very important when choosing a drug for cosmetic methods of wrinkle correction and minimizes the risk of side effects and reactions from the bodya .

Since 2012, carboxymethylcellulose hydrogel cross-linked with 1,4-butanediol diglycidyl ether (BDDE) has been successfully approved for wrinkle correction and facial contouring.

Studying the effectiveness of new drugs for facial contouring

Clinical studies of the safety of carboxymethyl cellulose fillers were conducted on 350 patients over a period of 4 years.

All patients were followed up for 36 months after contouring to assess the risk of adverse reactions and the long-term effect.  

The study included patients with significant or pronounced nasolabial folds.

The wrinkles were visible and symmetrical with a minimum score of 3 on a five-point scale in accordance with the approved Wrinkle Severity Scale (WSRS - five-point wrinkle severity scale from [0] - "no" to [5] - "pronounced".

Wrinkle depth scores were recorded at baseline and immediately prior to the upcoming procedure.

Study results showed sufficient correction and achievement of nasolabial wrinkle leveling in 99.7% of participants using the WSRS and GAIS scales at a visit 3 months after the first correction with fillers Erelle Biotech based on carboxymethyl cellulose.

Clinically significant improvement was maintained at each subsequent evaluation period in approximately two-thirds of subjects on the same rating scales, while outcome had an individual duration of 9 to 12 months prior to each filler reinsertion.

Injection technologies in cosmetology

When tested for biocompatibility of fillers Erelle, carboxymethyl cellulose was found to be:

non-toxic;

• non-irritating;
• non-sensitizing;
• non-genotoxic.
1,4-butanediol diglycidyl ester was chosen for chemical crosslinking based on 15 years of experience in its use in hyaluronic acid fillers.

The finished product has less than 1 ppm of crosslinker

e. Rheological properties and capabilities of Erelle fillers

Carboxymethylcellulose

, which is the basis of Erelle fillers for contouring, is obtained from plant sources. With the help of modern purification techniques, the polysaccharide molecule is completely freed from protein detritus and bacterial residues, which eliminates possible

allergic reactions

and product intolerance.

fillers

Erelle, a low level of local inflammatory reaction and satisfactory duration of the result of contouring – up to 12 months.

The rheological properties of

Erelle fillers are significantly superior to those of existing fillers in the aesthetic medicine market: a modulus of elasticity (G’) of approximately 320 Pa, which is currently significantly higher than all monophasic products, and thus the filler is able to stay in the tissues for a longer time.

How to minimize bruising and swelling after filler The complex modulus (G*) was also high, which confirms the greater ability of

carboxymethylcellulose

in Erelle fillers to resist skin tension forces and provide a better lifting effect. The excretion of carboxymethyl cellulose occurs naturally with the help of the cellulase enzyme, and is completed by macrophages.

It is important to note that this enzyme acts only on CMC molecules, without changing the surrounding tissues, since there are no similar substrates for this reaction in the body. Given that carboxymethylcellulose is a polysaccharide, the end products of decomposition are glucose and carbon.

How to deal with complications of filler injections Thus, with the release of

fillers Erelle by Biotech, aesthetic medicine specialists will have new opportunities for injectable techniques for correcting age-related changes which can guarantee perfect safety and efficiency.