The most common skin diseases in hyperandrogenism syndrome

What happens in the skin of women under conditions of exposure to increased levels of androgens or increased sensitivity of the sebaceous glands to them? & nbsp; Androgen-induced hyperproduction of sebum is observed, which is clinically manifested by an increase in skin oiliness and the formation of open comedones : first on the skin of the face in the area of ​​the nose, forehead, chin, which then tends to spread to the skin of the entire face, back, chest.

Find out in the article on estet-portal.com which are the most frequent skin diseases occur in hyperandrogenism syndrome.

• follicles in hyperandrogenism syndrome
• clinical signs of skin pathology against the background of hyperandrogenism syndrome
• approaches to the treatment of skin lesions against the background of hyperandrogenism syndrome

The state of follicles in hyperandrogenism syndrome

The oiliness of the skin in hyperandrogenism syndrome also grows on the scalp, leading to the need for frequent washing.

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Under the influence of androgenic hormones, not only the quantity, but also the quality of the secretion of the sebaceous glands changes: the content of follicular cholesterol sulfate increases in it, which enhances the adhesion of epitheliocytes in the acroinfundibular part of the follicle (epidermal part of the follicular canal) and is one of main causes of follicular hyperkeratosis.

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Another reason is insufficient disintegration of epitheliocyte desmosomes in the stratum corneum of the epidermis. This leads to inhibition of the rejection of epithelial cells in the follicular canal and "blockage" sebaceous gland with horny masses. As a result, closed comedones form on the skin .

Clinical signs of skin pathology against the background of hyperandrogenism syndrome

Since, as a result of blockage of the excretory duct of the sebaceous gland by horny masses, air access to it is terminated, favorable anaerobic conditions are created inside the gland for the development of Propion and bacterium acnes   ─ the main etiological factor of inflammatory forms of acne.

Clinically, this is manifested by the formation of papules and pustules that are painful on palpation.

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In some individuals with hyperandrogenism syndrome, acne vulgaris may have a mild course with the formation of only comedones; however, 

in most patients, the comedonal form of acne quickly turns into papulo-pustular, which requires systemic therapy.

 

 

Extremely severe forms of acne, such as conglobata (acne conglobata) and inverse (acne inversa) are less common:

- conglobate acne characterized by the formation of a large number of comedones, papules, pustules, against which nodes, cysts, abscesses appear; in women with acne conglobata, other manifestations of hyperandrogenism are necessarily present, including ─ virilization;

- 

inverse acne is characterized by the appearance of nodes and cysts, which are combined with hydradenitis, chronic purulent-inflammatory diseases of the scalp, chronic folliculitis followed by formation of keloid scars .

Approaches to the treatment of skin lesions associated with hyperandrogenism syndrome

Severe acne usually requires systemic retinoids and sometimes surgery. And although the appointment of only combined oral contraceptives in hyperandrogenism syndrome is not effective enough, 

however, their use in combination therapy is mandatory in order to eliminate the adverse effects of androgenic hormones on the skin.

 

 

The use of combined oral contraceptives containing drospirenone will prevent the progression of severe forms of acne and the formation of new rash elements in confirmed hyperandrogenism syndrome.

The impact of external factors and hormones on the condition and processes of skin aging

Thus, in cases of seborrhea and acne on the background of hyperandrogenism in women, preference 

should be given to combined oral contraceptives, which contain drospirenone (as an active substance).

Drospirenone, which is a derivative of spironolactone, affects & nbsp;

the main triggers for the development of seborrhea and acne in hyperandrogenism syndrome : inhibits the secretion of androgens by the ovaries by reducing luteinizing hormone; increases the level of globulins that bind sex hormones due to the estrogen component; reduces the secretion of androgens by the ovaries and adrenal glands; inhibits 5α-reductase; blocks androgen receptors of the skin and hair follicles; provides control of body weight; reduces the manifestations of premenstrual syndrome.

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