Ultraviolet (UV) radiation is one of the main factors that causes photoaging of the skin, which leads to dryness and loss of elasticity. Ultraviolet type A (UV-A) represents 90% of the total spectrum of solar radiation, however, both ultraviolet type B (UV-A) and type B (UV-B) have a negative effect on epidermal cells ( keratinocytes, melanocytes, Langerhans and Merkel cells), by metabolic disorders. About what mechanisms and skin care products can actively resist the degradation of collagen and elastin during photoaging, as well as increase the ability of skin cells to repair, read on estet- portal.com
- Reactive oxygen species and skin photoaging
- Hyaluronic acid and prevention of skin photoaging
- Amino acids as free radical scavengers for skin photoaging
Reactive oxygen species and skin photoaging
It is important to remember that ultraviolet photons tend to damage the skin, even after brief exposure, by causing phosphorylation of the c-Jun N-terminal kinase (JNK) enzyme, as well as by increasing intracellular reactive oxygen species in skin keratinocytes .
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Many studies have reported the effect of reactive oxygen species on keratinocytes, which also proves the leading role of external factors in the development of premature skin aging, in particular photoaging, by generating reactive oxygen species. Professor S.Mouret with a working group reported on a wide range of effects of UV-A on the process of DNA damage. UV-B rays also have a similar effect.
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Photons of this spectrum are able to penetrate into the deep part of the dermis and destroy the connective fibers of collagen and elastin. As a result, the macromolecular makeup of proteins such as collagen and elastin in the skin can be disrupted or altered, causing the skin to thin and lose elasticity. The process leads to the catabolism of extracellular matrix components (collagen and proteoglycans) that provide skin tone. This phenomenon is associated, in particular, with increased expression of matrix metalloproteinases.
Many studies have shown that accelerated degradation of type I collagen occurs precisely during skin photoaging.
In addition, excessive exposure to ultraviolet radiation causes a change in the biomechanical properties of the connective tissue of the skin matrix, which leads to dryness and reduced elasticity. These changes are associated with DNA damage caused by the production of reactive oxygen species (ROS), which leads not only to premature skin aging, but also increases the risk of skin cancer. In addition, ROS, by inducing apoptosis, reduce the number of skin fibroblasts and reduce their regenerative capacity, which leads to sagging of the skin and a decrease in its turgor.
Thus, the identification of new compounds that are effective in protecting cells during photoaging of the skin, is an important means of preventing the development of those processes that are caused by ultraviolet radiation. Several basic studies currently exist that describe the mechanisms of action of various formulations of skin care products, considering their effect on reducing the formation of free radicals generated by
Today, the stimulation of skin biorejuvenation is facilitated by minimally invasive intradermal injections of biologically active substances,
such as gels based on hyaluronic acid (HA) alone or in combination with other molecules. Follow our updates on
Facebook! Report by a group of researchers Antonietta Stellavato, Anna Virginia Adriana Pirozzi, Stella Donato et al. in "
The positive effect of using a hyaluronic acid formulation containing amino acids, vitamins and minerals against UV-A-induced damage and oxidative stress on the cell model in vitro» show that hyaluronic acid accelerates the processes associated with wound healing and tissue regeneration in vivo, and also increases the production of extracellular matrix components that reduce the signs of aging.
Read also:An easy-to-use peel for complex problems In particular, hyaluronic acid enhances hydration in the extracellular space due to its ability to attract water molecules and induces optimal physiological conditions in the extracellular matrix for cell proliferation and fibroblast organization
. Therefore, the reparative effects of hyaluronic acid have been proposed as an effective remedy for skin photoaging. Composition RRS® HA LONG LASTINGby Academy of Scientific Beauty for intradermal administration, containing linear hyaluronic acid and antioxidants that are able to suppress oxidative stress-induced apoptosis in skin fibroblasts, can be a potential means of maintaining the health of young skin in photoaging.
and, as a result, improving the appearance with elements of volume modeling. RRS® HA LONG LASTING – this is a unique development of an injectable hybrid drug with the properties of a filler and a biorevitalizant.
The protective complex of the drug is represented by osmolyte and an amino acid cluster. Osmolyte is designed to eliminate local osmotic stress in tissuesdue to injection of the drug. The amino acid cluster is intended for continuous protection and reduction of collagen and elastin biodegradation during skin photoaging, while being an additional building material. Amino acids as scavengers of free radicals in skin photoaging
In particular, in the study of the drug RRS® HA LONG LASTING
amino acids have been found to help skin cells resist the damaging effects of reactive oxygen species and are activated relatively late after initial UV damageand therefore can be considered as cell structures providing protection against a "late inflammatory response" ;.
Read also:Cellular mechanisms of regulation of the process of skin renewal Also, a study by Prof. Antonietta Stellavato et al. confirmed that intradermal use of hyaluronic acid with other active ingredients can increase keratinocyte function.
In particular, the amino acids present in RRS® HA LONG LASTINGby Academy of Scientific Beauty, are important nutrients for maintaining youthfulness in photoaging skin: this complex acts as a free radical scavenger.
The drug can be successfully used by cosmetologists in the correction of skin photoaging, as well as dermal atrophy and tissue deficiency.
RRS® HA LONG LASTING – these are new possibilities for aesthetic and functional correction of skin photoaging and age-related changes.More useful information on our