Periostin is a landmark protein that allows the identification of allergic diseases such as asthma, hay fever, and atopic dermatitis. Recently, American scientists have found that the LIGHT cytokine can influence the synthesis of this protein.
Thus, these data can be a big breakthrough in the treatment of atopic dermatitis, since by blocking the effects of the LIGHT factor, it is possible to achieve not only remission of the disease, but also a complete recovery.
Read more about this study on estet-portal.com in this article.
LIGHT: can a cytokine cause atopic dermatitis
Atopic dermatitis – it is an allergic disease that usually develops in early childhood and belongs to the group of chronic inflammatory dermatoses.
Many scientists are trying to find its cause, since more than 10% of the population is affected by this disease.
Scientists from the La Jolla Institute have identified a factor that contributes to the development of allergies and skin inflammation, and therefore stimulates the clinical manifestation of atopic dermatitis.
Their work demonstrates that LIGHT, a member of the tumor necrosis factor (TNF) family, induces hyperproliferation of keratinocytes and also controls the synthesis of the pro-inflammatory protein periostin.
New options for the treatment of atopic dermatitis in children and adults
What is the LIGHT factor and how does it work
LIGHT is a cytokine primarily produced by T cells that mediates the cascade of reactions that promote skin inflammation in scleroderma and atopic dermatitis.
LIGHT affects the synthesis of the protein periostin, which is responsible for the clinical manifestations of inflammatory dermatoses.
LIGHT stimulates skin cell division and consequently its structural remodeling.
In fact, antibodies that neutralize LIGHT activity can successfully suppress the symptoms of the disease. Therefore, treatments based on blocking LIGHT are a very promising treatment option for atopic dermatitis.
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Research on the role of the LIGHT factor in the etiology of atopic dermatitis
To determine whether LIGHT contributes to the development of an inflammatory skin reaction in atopic dermatitis, American scientists conducted an interesting experiment, as a result of which it was found that LIGHT-deficient mice had minimal clinical manifestations of the disease.
LIGHT acts as a pro-inflammatory molecule for immune and non-immune skin cells (eg keratinocytes).
The researchers also used specific antibodies to block the interaction of LIGHT with its receptor. Antibody treatment suppressed skin inflammation, and greatly reduced epidermal damage.
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