Each patient who seeks the help of a cosmetologist wishes, to one degree or another, to slow down the aging process or reverse it. Scientists are actively working to solve this problem, studying in detail the mechanisms and factors of aging, as well as ways to influence them. To date, it is known that the aging process occurs under the influence of three key factors – genetics (30%), lifestyle (50%) and stress factors (20%). Thus, genes determine how a person ages, only 30%, and the remaining 70% – these are epigenetic factors that we can (and should!) influence. By doing this effectively, you can maximize the youthfulness of the body in general and the skin in particular. In cosmetology, biomimetic peptides are used for this purpose. In the article estet-portal.com Evgenia Baranova – general practitioner, dietician-nutritionist, brand manager of TOTISPHARMA GROUP – talks about the effectiveness of biomimetic peptides in slowing down the aging process of the skin.
- Epigenetics: how to reverse the aging process
- Biomimetic peptides – the newest weapon in the arsenal of the modern cosmetologist
- Epigenetic Serums INNO-EPIGEN – effective protection and prevention of skin aging
Epigenetics: how to reverse the aging process
The regulation of gene expression is carried out under the influence of such epigenetic factors as the level of physical activity, nutrition, external environmental factors and the emotional state of a person. Moreover, their influence can be both positive and negative.
If we talk about the skin, in many cases, cosmetologists have to solve a difficult task – mitigate the consequences:
- physical inactivity;
- unhealthy eating;
- chronic stress;
- the negative impact of the ecology of modern megacities.
Epigenetics is concerned with the study of biochemical reactions and processes that modify the activity of DNA without altering its basic sequence.
What role does epigenetics play in this?
Lifestyle and external stressors trigger reversible changes in DNA that "turn on" and "turn off" certain genes. These changes accumulate over time and disrupt the proper functioning of cells. Deciphering the language of these small chemical changes is the key to preventing and even reversing the aging process, because epigenetic mechanisms are able to regulate the activity of each gene in the same way as dimmer – dimmer for incandescent lamps.
Biomimetic peptides – the newest weapon in the arsenal of the modern cosmetologist
Biomimetic Peptides – signal molecules that are used in modern cosmetology to neutralize negative epigenetic changes and activate their own regenerative potential of skin cells. Specialists of the Spanish pharmaceutical laboratory INNOAESTHETICS, based on the cutting-edge discoveries of molecular biology and epigenetics, have developed a unique line of professional cosmetics with epigenetic components, the anti-age effect of which has been confirmed in numerous scientific studies.
- Chronogen® (Tetrapeptide-26)
This biomimetic peptide aims to increase the expression of clock genes. Proteins of "sentinels" genes such as JARID1a form the circadian rhythm of skin activity. Chronogen® biomimetic peptide (Tetrapeptide-26) is associated with maintenance of expression:
- mPER1 – the main gene underlying the regulation of the circadian rhythm;
- CLOCK and BMAL – transcription factors that regulate the expression of mPER1.
Chronogen® (Tetrapeptide-26) acts on the skin as an anti-stress, anti-age and protective agent.
Chronogen® Biomimetic Peptide helps maintain and synchronize your internal clock skin:
- in the daytime helps to reduce UV-induced damage to DNA cells;
- at night stimulates the processes of repairing damaged DNA and active skin regeneration.
- Urbalys® (Schisandra chinensis extract)
Key effects of this biomimetic peptide:
- increases skin resistance to aggressive stress factors and environmental pollution;
- stabilizes cell membranes and strengthens the epidermal barrier;
- activates endogenous antioxidant defense mechanisms and cellular detox systems.
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Urbalys® helps to combat the negative impact of air pollution in modern megacities – free radicals, reactive oxygen species and aeropollutants, providing:
- barrier function restored;
- antioxidant cell protection;
- reduction of inflammatory reactions.
- Detoxiquin® (ice mushroom extract + iron hexapeptide 35)
The biomimetic component Detoxiquin® combines a natural active ingredient (ice mushroom extract) and a synthetic biomimetic peptide (iron hexapeptide 35) capable of:
- increase superoxide dismutase activity;
- minimize lipid peroxidation (oxidative stress);
- reduce damage to DNA and proteins.
The biomimetic component Detoxiquin® neutralizes free radicals that cause intracellular accumulation of oxidative damage.
Thus, Detoxiquin® prevents premature aging of cells and promotes their regeneration.
Epigenetic Serums INNO-EPIGEN – effective protection and prevention of skin aging
Innovative biomimetic peptides are included in INNO-EPIGEN epigenetic serums from the official distributor of the Spanish pharmaceutical laboratory INNOAESTHETICS in Ukraine – company TOTISPHARMA GROUP.
INNO-EPIGEN Pigment Defense Serum – epigenetic serum for the prevention and supplementation of the complex therapy of hyperpigmentation.
This is a powerful combination of depigmenting active ingredients that acts at different stages of melanogenesis:
- inhibits melanin synthesis;
- prevents its transport;
- promotes its elimination from cells.
The serum is intended to supplement the complex therapy of hyperpigmentation of various origins and prevent its recurrence.
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Composed of: complex of active epigenetic ingredients (Urbalys® and Chronogen®), apricot kernel oil, retinol, ethyl-ascorbic acid, niacinamide, potassium azeloyl diglycinate, bisabolol, tocopheryl acetate, Narcissus bulb extract, phytic acid and Smart-GPS®
INNO-EPIGEN Purifying Serum – epigenetic serum for oily and combination skin prone to breakouts.
The serum regulates sebum production and fights enlarged pores, providing an even tone and radiance of the skin. Promotes cellular detoxification and eliminates free radicals. Inhibits the growth of bacterial flora and prevents rashes and acne.
The serum is designed for daily care of oily and combination skin prone to breakouts.
Ingredients: Active Epigenetic Ingredients Complex (Urbalys® and Chronogen®), Potassium Azeloyl Diglycinate, Apricot Kernel Oil, Retinol, Oleanolic Acid, Narcissus Bulb Extract, Nordihydroguaiaretic Acid, Micrococcus Lysate, Tocopherol, Biotin and Smart GPS®.
INNO-EPIGEN Age Perfection Serum – epigenetic serum for the prevention and addition of complex therapy for photo- and chronoaging of the skin.
The unique combination of epigenetic ingredients contributes to a unique rejuvenation strategy that is implemented by protecting cell DNA from oxidative damage and preventing the so-called inflammaging – skin aging associated with chronic inflammation. Promotes cellular detoxification and elimination of free radicals, stimulates the synthesis of endogenous collagen and hyaluronic acid, reduces transepidermal water loss (TEWL).
Composed of: complex of active epigenetic ingredients (Urbalys®, SYN®-TC, Rubixyl®, Chronogen® and Detoxiquin®), bakuchiol, retinol, Narcissus bulb extract and Smart GPS.
INNO-EPIGEN Antiox Serum – antioxidant epigenetic serum for absolute protection against free radicals and effective prevention of skin photoaging.
The serum restores cellular DNA and provides the perfect skin texture. The skin looks renewed, smooth, has a healthy uniform tone. Thanks to the synergy of the latest generation of active ingredients and biomimetic peptides, the serum has a powerful antioxidant effect and stimulates detoxification processes in cells.
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Composed of: a complex of active epigenetic ingredients (Urbalys®, Preventhelia®, Chronogen® and Detoxiquin®), Shandra extract, Edelweiss stem cell extract, dimethylmethoxy chromanol, Narcissus bulb extract, sodium ascorbyl phosphate and Smart GPS.
All INNO-EPIGEN sera contain the Smart GPS® system.
Smart GPS® (Guidance Performance System) – unique patented active ingredient delivery technology that ensures that each active ingredient is effectively penetrated and released in the layer of the skin where it will be most effective.
Unique active ingredient delivery system Smart GPS® by INNOAESTHETICS – guarantee of the best aesthetic result.
INNO-EPIGEN serums are used in comprehensive epigenetic home care protocols for:
- skin with signs of photo- and chrono-aging in anti-age programs – Age Perfection Serum;
- dry and dehydrated skin – Antiox Serum;
- oily and combination skin prone to breakouts – Purifying Serum;
- skin prone to hyperpigmentation (melasma/chloasma, lentigo) – Pigment Defense Serum.
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