Factors that contribute to the development of infertility in men

Overweight and obesity are known to affect male fertility and are commonly associated with abdominal obesity and metabolic disorders, but this relationship is not fully understood.

Researchers have linked obesity to infertility in both men and women, but this cannot be the only factor.

Find out in the article on estet-portal.com the results of a scientific study of metabolic factors that contribute to the development of infertility in men.

Research on the causes of infertility in men

Several studies have found changes in sperm parameters, namely a decrease in sperm count in overweight and obese individuals, and other studies confirm that sperm concentration in men has decreased by 52.4% over the past 50 years.

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It is hypothesized that this decrease may be due to various factors such as exposure to pollution, radiation, high temperatures, as well as lifestyle, which can threaten the production of male germ cells, namely smoking, malnutrition, lack of physical activity , overweight, obesity and metabolic syndrome.

In particular, the relationship between male infertility and lifestyle factors is of interest to scientists because of the potential impact.

Potential factors in the development of infertility in men

Smoking has been proven to be detrimental to people's health. In addition to affecting the cardiovascular system, smoking has a carcinogenic effect and challenges the reproductive function of both men and women. Although weight gain has been reported after smoking cessation, several studies have shown that smoking increases the risk of metabolic syndrome and abdominal obesity. In addition, smoking cessation may improve metabolic performance.

Abdominal obesity − one of the components of the metabolic syndrome. Metabolic syndrome is defined as a combination of at least three factors, including high waist circumference, hyperglycemia, high blood triglycerides, elevated blood pressure, and low high-density lipoprotein (HDL) levels.

Medicated improvement of sperm properties in idiopathic infertility

French scientists conducted a study, the purpose of which is − to investigate the potential association of metabolic syndrome with idiopathic infertility in men who smoke.

The study involved 96 infertile and 100 fertile men under the age of 45 years. All participants in the analysis − Caucasian faces. At the beginning of the study, semen culture and analysis of semen according to generally accepted parameters were performed.

The eligibility criteria were:

1) establishing a diagnosis of primary idiopathic infertility in men of duration > 12 months;

2) age of men

3) absence of severe oligozoospermia (

4) no changes in the organs of the male reproductive system;

5) absence of infertility factors in the female partner;

6) age of female partner

7) providing written informed consent.

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The control group consisted of fertile male volunteers. The inclusion criteria for this group were:

1) the presence of a child under the age of 2;

2) pregnancy for which the couple needed

3) age of men

4) age of female partner

5) providing written informed consent.

Metabolic syndrome was diagnosed when at least three of the following criteria were present: waist circumference> 92 cm, blood triglycerides ≥1.7 mmol/l, HDL <1.0 mmol/l, fasting blood glucose ≥5.6 mmol/l and systolic blood pressure ≥130/85 mmHg . Art. Patients reported the number of cigarettes smoked per day and were classified as smokers if they smoked one or more cigarettes per day and as non-smokers if they did not smoke at all.

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Key indicators of the study in the presence of infertility in men

There were no statistical differences between male infertility and fertile males in terms of age, total cholesterol, low-density lipoprotein (LDL) and triglyceride levels in the blood. Blood pressure values ​​also did not differ significantly.

Both metabolic syndrome and smoking were more common in infertile than fertile men: metabolic syndrome was noted in 17 of 95 infertile men versus 6 of 99 controls; 27 out of 94 participants in the group of infertile men smoked versus 14 out of 99 healthy individuals. Smoking status did not differ significantly between men with and without metabolic syndrome.

Change in sperm morphology: the cause of male infertility

Metabolic syndrome and smoking habit − important and independent risk factors for idiopathic infertility in men. Health care providers should be aware of this and systematically check for risk factors at the start of care, given that adverse effects can be prevented.

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