The aging process of the face and body occurs at different levels, therefore one of its characteristic features is the loss of soft tissue volume. In modern aesthetic medicine, fillers are used to correct wrinkles and soft tissue volume. Korean researchers at the Chung-Ang University Clinic have developed polylactic acid fillers Aesthefill and Powerfill, which have demonstrated high efficiency and safety in correcting lost volumes of the face and body.
Research confirming the efficacy and safety of polylactic acid fillers
Researchers led by Prof. Bem-Joon Kim (Chungang University) compared the results of poly-DL-lactic acid (PDLA, Aesthefill) and hyaluronic acid fillers on deep nasolabial folds in 58 Koreans.
During the study, patients were injected with PDLA or HA-based fillers in both nasolabial folds, and then the volunteers were followed up for 24 weeks. To determine the effectiveness of the procedure, the WSRS scale was used, and the safety – detected side effects.
Injections of both drugs have been shown to be highly safe and effective, with minor and transient side effects.
Study results were published in SCI Journal and Plastic and Reconstructive Surgery in 2015
PLA fillers:
- mechanism of action;
- benefits.
Aesthefill and Powerfill polylactic acid fillers mechanism of action
Polylactic acid – aliphatic, thermoplastic polymer obtained from corn and potato starch through a polymerization process. Medicines containing biodegradable polylactic acid break down naturally in the body without the need for surgical removal.
Aestefill and Powerfill – these are conceptually new fillers that use PLA (polylactic acid) globular particles.
There are 2 optical isomers of lactic acid – L-lactic and D-lactic acid, which have the same chemical and physical properties.
The main difference between PDLA fillers and existing ones is that they stimulate neocollagenesis, thanks to which its action is extended by 3-6 months.
Aesthefill and Powerfill fillers, developed by the Korean company REGEN Biotech, provide not only volume replenishment, but also stimulation of collagen production. These fillers use PDLA with a porous structure, and the uniform particle size provides more natural results and less pain than existing PLA fillers.
What happens after Aesthefill and Powerfill are injected into the skin?
After the filler is injected into the skin, globular PLA particles fill the voids in the tissues formed during the aging process. As the cells are distributed between the PLA particles, the process of regeneration of new tissues and collagen synthesis starts.
Immediate effect of volume replenishment and wrinkle smoothing is visible immediately after the injection of PLA filler into the target area.
About a week or two after injections, there is a slight decrease in volume, which is restored again after 4-8 weeks. Gradual collagen production is observed as cells penetrate the porous PLA particles.
Over time, PLA breaks down into lactic acid and glycogen through hydrolysis, after which it is excreted from the body in the form of water and CO2.
Histological analysis confirms the effectiveness of stimulating the production of new tissues and collagen:
* Pink (cytoplasm); dark pink or blue (cores)
Arrows: Cells migrate inside PLA particles
Benefits of using Aesthefill and Powerfill polylactic acid fillers
Aesthefill polylactic acid fillers are used for:
- loss of tissue volume in the temporal region;
- loss of volume in the cheek area;
- the presence of wrinkles in the corners of the eyes;
- presence of wrinkles around the mouth;
- presence of nasolabial folds;
- hand rejuvenation;
- cheekbone enlargement;
- presence of premaxillary folds;
- chin correction;
- the need to improve the general condition of the skin of the face, neck, decollete.
Benefits of Aesthefill fillers:
- active stimulation of neocollagenesis;
- ease of use;
- safety (PLA approved by FDA);
- no side effects;
- no occlusion of small vessels;
- Maintain tissue volume over a long period of time.
Powerfill polylactic acid fillers are used to:
- body corrections;
- intimate plasticity.
Powerfill Benefits:
- natural and lasting effect;
- product is patented in the local and global market;
- safe, non-toxic;
- KFDA approved;
- FDA approved raw material;
- Clinically tested.
A new generation of Aesthefill and Powerfill fillers with microparticles of polylactic acid – development Korean company REGEN Biotech – provides natural restoration of tissue volume, revitalization and filling of wrinkles.
For more information and to order Aesthefill and Powerfill fillers for face and body correction, you can contact the exclusive distributor in Ukraine – of Nano Bio Medical (NBM).
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