Immunomodulators against psoriasis: due to what they are effective

Recent years of research in the field of psoriasis therapy pay close attention to the possibilities of drugs that can affect the immune system.  Usually these are low molecular weight compounds that have & nbsp; anti-inflammatory,  anxiolytic,  antioxidant properties and at the same time are able to influence the activity of leukocyte cells. A number of such drugs affect the functional metabolic activity of macrophages, inhibit the production of tumor necrosis factor (TNF-a), interleukins and other pro-inflammatory cytokines. Another property of immunomodulator preparations, valuable in the fight against psoriasis, & nbsp; is that they can inhibit the production of reactive oxygen species by macrophages, creating obstacles to the development of oxidative stress, which often becomes a characteristic sign of psoriasis. Thanks to immunomodulators, the functional state of macrophages is normalized, which leads to a decrease in the level of autoaggression in the skin, while the functions of G-lymphocytes are restored and the effectiveness of the fight against psoriasis is significantly increased.

Clinical Study

The following study was conducted regarding the action of immunomodulatory drugs and their effectiveness in psoriasis.

We examined 37 patients with an established diagnosis: "common psoriasis vulgaris". The age of patients is 18-60 years. The study was open, randomized, the method of simple randomization into the main and control groups was used.

Treatment. The main group included 19 patients who, along with traditional dermatological treatment, received an immunomodulator in the form of a suppository in a course of 15 every other day. Patients in the control group 18 people received aevit, calcium preparations and topical salicylic ointment.

Results. The assessment was carried out one month after the start of therapy based on a clinical examination and using the PASI scale: no  changes – the index does not change or deviates slightly, the – the index is reduced by 50%, a significant improvement – the index is lower by more than 85%, the stage of remission – complete disappearance of manifestations of psoriasis on the skin.

The results of the study showed that in the complex treatment group, where patients took immunomodulators simultaneously with dermatological prescriptions, the rate of favorable outcomes was significantly higher.

Laboratory data showed that immunomodulators reduced the production of such an active pro-inflammatory cytokine as skin necrosis factor TNF-a, and normalized the functional activity of T-lymphocytes.

To date, such drugs as lycopene, thymalin, cycloferon, thymodepressin, xymedon, cyclosporine, polyoxidonium, galavit have demonstrated their effectiveness in the treatment of psoriasis.

Researchers also note the undoubted importance of the antioxidant and anti-anxiety effects of immunomodulators, point out that when prescribing drugs against psoriasis, it is necessary to take into account the close contact of the immune and nervous systems, their direct connection with the skin, which can significantly increase the effectiveness of psoriasis treatment.