Fibroblasts are often credited with completely magical properties, considering them a panacea for age-related changes in appearance. However, the effect of their activity is not in vain compared with the action of stem cells – the mechanism of their work is really very similar, and thanks to the production of growth factors and other elements important for skin health, fibroblasts become a key component of anti-aging programs.
Usually, when talking about stimulating the activity of skin fibroblasts, they mean complex and expensive procedures associated with autoplasma and high-tech equipment. However, even in the conditions of a cosmetology parlor, by means of simple procedures, it is possible to start the processes of activation of skin fibroblasts. How to do it – prompt estet-portal.com.
What is the importance of fibroblast activity for skin condition
The tasks that fibroblasts perform in the body are mainly reduced to synthesizing the intercellular matrix, which provides mechanical support to skin cells, and to transporting the necessary nutrients to the skin in the right direction.
Mature fibroblasts are capable of producing substances called precursors of collagen, elastin, hyaluronic acid, and fibrin. They later form collagen and elastin fibers, proteoglycans that make up the intercellular matrix.
Dermal fibroblasts perform several important functions in the skin:
- reference – provided by collagen and elastin fibers;
- plastic – adaptation of damaged skin to external conditions, its regeneration, formation of scar tissue;
- morphogenetic – formation of tissue complexes, regulation of tissue proliferation and differentiation.
Another important function of fibroblasts, which is especially relevant when carrying out complex anti-aging procedures – synthesis of growth factors that play a significant role in many processes occurring in the skin, including those responsible for its epithelization. Thus, directly in fibroblasts are synthesized:
- Epidermal Growth Factor (EGF) – stimulates cell growth and cell differentiation;
- transforming growth factor alpha (TGF-alpha) - consists of 50 amino acids, initiates angiogenesis;
- transforming growth factor beta (TGF-beta) - actively stimulates fibrogenesis, angiogenesis, acts as an inhibitor of proteolysis;
- platelet growth factor - stimulates protein synthesis in target cells, has a pro-inflammatory effect, increases collagen synthesis;
- transforming growth factor (a-NGF) - actively influences angiogenesis.
For its part, our body produces a number of substances that are capable, with a certain stimulation, of increasing the activity of fibroblasts – these are interleukins, fibroblast growth factors, some components of the extracellular matrix (for example, proteoglycans).
What cosmetic procedures affect the activity of fibroblasts
The following procedures affect the functional activity of fibroblasts and prolong their life cycle:
- any peels (mechanical, chemical, microdermabrasion) – they injure the skin and cause an inflammatory response, stimulating the activity of fibroblasts to repair damaged tissues;
- injection procedures with hyaluronic acid preparations (mesotherapy, biorevitalization) – in this case, there is both the fact of skin injury and stimulation due to additional hyaluronate molecules;
- use of non-invasive preparations containing fibroblast growth factors – here fibroblasts act as target cells, which triggers the synthesis of collagen in the skin;
- native collagen injections – cause an inflammatory process in the injection area and provoke a response fibrillogenesis.
Among the more technically complex procedures, one cannot fail to mention plasmolifting, PRP-lifting – when a patient is injected with platelet autoplasma with a high concentration of growth hormones that cause the formation of new active fibroblasts, the renewal of the extracellular matrix, and the launch of skin cell regeneration processes.
Unfortunately, there are factors that negatively affect the synthesis of fibroblasts – excessive ultraviolet solar radiation, smoking, hormonal imbalance during pregnancy or perimenopause. They must be taken into account when planning procedures aimed at complex skin rejuvenation.
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