How does the activity of phagocytes change in acne

Acne disease occupies one of the dominant positions in the structure of dermatovenerologic pathologies.

It has a frequency of 3% to 90% depending on age.

The illness has a range of psychosocial consequences due to emotional stress.

This is the patient's concern for his condition and appearance, difficulties in interpersonal relationships and in professional activities.

Basic pathogenetic moments in the development of acne have been studied.

However, little is known about the state of the immune system of patients, which affects the development of the disease and its recurrence.

Let's look at estet-portal.com cellular immunity reaction, namely metabolic activity of phagocytes in the peripheral blood of patients.

• Important pathogenetic factors of acne
• What substance can be used to determine the activity of phagocytes
• Acne Symptoms Observed in Study Patients
• The results of determining the activity of phagocytes in acneand

Important pathogenetic factors of acne

In the process of development of any disease, several main pathogenetic factors of development are distinguished, which determines the complexity of the process.

Several factors determine the severity of acne:

• chronic course;
• polyetiology;
• insufficient study of some pathogenic chains;
• frequent relapses;
• resistance to many groups of drugs.

Pathogenetic factors of acne include:

• increased secretion of sebaceous glands, often this process is androgen dependent;
• increased sensitivity of receptors on the surface of the sebaceous glands;
• colonization of sebaceous hair follicles Propionibacterium acnes;
• hyperproliferation and impaired differentiation of follicular keratinocytes;
• increased activity of 5a-reductase;
• spread of inflammation.

A special place in the development of dermatoses belongs to the state of the immune system, the work of the endocrineth system and the functioning of the digestive system.

The main causes of acne and the protocol for effective acne treatment

What substance can be used to determine the activity of phagocytes

To date, the metabolic activity of peripheral blood phagocytes in patients with acne has been little studied.

This does not allow an adequate assessment of the effectiveness of metabolic therapy, which is given much attention in the treatment process.

An important indicator of cell metabolism is its cytochemical activity.

It is known that the cytochemical activity of leukocytes is, although non-specific, but rather sensitive indicator of changes in the overall resistance of the body. Cytochemical methods maximally preserve intracellular morphology of intracellular compounds, have high sensitivity to their minimal content. 

The choice of a substance such as glycogen is based on the metabolic value of the cell, since when it breaks down in the form of macroergs, energy is released, which is necessary for the life of cells.

Therefore, assessment of the metabolic activity of phagocytes in the peripheral blood of acne patients was carried out by detection of glycogen content inside the cellcurrent.

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Acne Symptoms Observed in Study Patients

There were 47 patients under observation for acne, among them 28 women and 19 men aged 16 to 37 years.

The duration of their illness varies from six months to 16 years.

Half of the patients have mild acne and the other half have moderate acne.

Patients were treated both in a hospital, outpatient setting, and at home. Treatment consisted of systemic antibacterials, antiseptics, topical retinoids and antiandrogens.

The control group consisted of 15 healthy people.

With a mild degree of acne on the skin of the face, chest and shoulder girdle, as well as on the neck, open and closed comedones, single miliary papules pink and superficial pustules.

Most patients had hyperpigmented spots.

With moderate severity there were more rashes.

7 patients had deep pustules and nodules, 9 patients had small atrophic scars.

General clinical studies did not reveal pathological changes in the CBC, TAM, blood glucose test, fecal test for helminth eggs.

Glycogen content in neutrophils and monocytes of peripheral blood was determined by PAS-reaction.

The results of the reaction were evaluated using the average cytochemical coefficientnta (MCC).

Relationship between the concentration of sex hormones and the course of acne

The results of determining the activity of phagocytes in acne

The content of glycogen in neutrophils of the peripheral blood of the control group was MCC= 2.31.

At the same time, the overall level of PAS-positive cells was in the range of 91-100%.

The indicator was formed due to a large number of neutrophils with an average and high metabolite content.

During the observation, it was revealed that in patients suffering from acne, there is a redistribution of glycogen content in leukocytes of peripheral blood, which depends on the severity of the pathological process.

This indicates changes in the energy potential of their individual subpopulations.

Thus, the content of the metabolite in neutrophils with mild acne decreased to MCC= 2.05 (in control 2.31).

These indicators were formed due to the inhibition of the total number of PAS-positive cells and hemoelements with an average glycogen content.

With moderate severity of the process, the MCC decreased to 1.72, and this was also against the background of inhibition of PAS-positive cells and cells with an average glycogen content.

However, the number of hemoelements with a low metabolite content remained within the physiological limits.

Thus, in the neutrophils of the peripheral blood of patients with acne, the glycogen content is inhibited,which in turn is accompanied by an increased level of the metabolite in monocytes.

Such changes indicate a restructuring of the metabolic activity of phagocytes. Such changes in the metabolic activity of phagocytes should be taken into account when choosing a therapeutic tactic.

Changes in the cells of the immune system may be an additional criterion for the appropriateness of individualized metabolic therapy in the complex treatment of acne.

Acne: a serious condition with serious causes