For most people, just the thought of losing their hair for a few months will seem like a real nightmare. But for two people in a thousand, this is a horrifying reality.
Hair loss puts psychological and social pressure on a person, patients with alopecia areata lose their self-confidence. They learn to accept themselves and love as they are, however, they are ready for anything to return their lost hair.
Inhibitors Janus kinase, ruxolitinib and tofacitnib, interact with intracellular signaling pathways involved in the pathogenesis of alopecia areata and are currently being studied as possible treatments.
For more information about these drugs, please visit estet-portal.сom in this article.
- Alopecia areata – no sentence
- Pathogenesis of alopecia areata
- Searching for an effective treatment for alopecia areataand
Alopecia areata – not a sentence
Alopecia areata usually appears before the age of 30 years. Most patients end up with a few temporary patches of alopecia, but in about a quarter of people who have the disease often onset in childhood, it results in the loss of all head hair (alopeciatotal) or body (alopecia universal).
The prognosis for hair growth in alopecia areata is unfavorable, and the worse it is, the earlier the disease began. In addition, there are currently no clinically proven treatments.
Most of the treatments available today do not work as expected.
Because it is difficult to distinguish between the effect of the drug and spontaneous hair regrowth, the true success rate of any treatment is unknown.
1) Alopecia areata 2) Total Alopecia 3) Alopecia universalis
However, this bleak picture may change as genetic studies allow scientists to understand what targets should be targeted for alopeciaand.
Alopecia areata: proven techniques and possible treatment errors
Pathogeny of alopecia areata
Normal hair follicles, like other organs, are not of interest to the human immune system. However, in alopecia areata they mistakenly express autoantigens, danger signals that tell the immune system to destroy them.
Suppression of the immune response is one of the treatments for alopecia areata, however, it often provides only a temporary result, and in patients with a rapidly progressive form of the disease, it may not work at all.
Cortisone treatment of alopecia areata, given topically, subcutaneously, or systemically, only suppresses the immune system and does so temporarily.
Thus, to effectively treat alopecia, like other autoimmune diseases, it is necessary to block the signal that triggers the immune responset.
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Searching for an effective treatment for alopecia areata
ULBP – it is a gene that codes for the synthesis of self-antigens on the surface of hair follicles.
When the T cell interacts with the ULBP-encoded surface protein, an intracellular cascade is set in motion that destroys cells of the dermal sheath of the hair follicle.
Some of the intracellular processes are mediated by a tyrosine kinase called Janus kinase (JAK). By inhibiting it, it is possible to negate the destruction of follicle cells.
American researchers may have found a drug for effective treatment for alopecia areata.
In 2014, Angela Cristiano, a geneticist at Columbia University, New York, and her colleagues published preliminary results showing that oral ruxolitinib, an FDA-approved drug for the treatment of myelofibrosis bone marrow, restored almost full hair growth precisely due to the inhibition of Janus kinase.
The main reason researchers and pharmaceutical companies should invest in alopecia areata research is the unique opportunity to study a model of an autoimmune disease.
Another JAK inhibitor called tofacitinib has also been tested and is approved by the US FDA for the treatment of rheumatoid arthritis.
However, the first studies showed that after stopping the drug, the hair growth cycle was again disturbed. Scientists claim that this may be due to insufficient duration of use of the drug.
In addition, there is an opinion thattopical use of these drugs will reduce their side effects, resulting in the possibility of long-term use of drugs for supportive therapy.
New protocol for the treatment of alopecia: mesotherapy + botulinum toxin
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