Today, more and more people pay attention to their skin condition, as it is a marker of the state of internal organs. Also – it is one of the most important organs of protection and maintenance of homeostasis, but, unfortunately, the skin is the first to take the blows of polluted environment, chlorinated water, malnutrition and stress.
Find out in the article on estet-portal.com why skin electroporation is considered one of the most effective procedures in aesthetic medicine, as well as the advantages of this procedure over other hardware techniques.
- Premature skin aging triggers
- Benefits of skin electroporation
- Mechanism of rejuvenation and recovery with skin electroporation
Premature skin aging triggers
In cosmetics, there are various ways to deal with the most important problems, such as acne and wrinkles. Skin damage occurs as a result of hormonal imbalance, excessive exposure to ultraviolet radiation, as well as a decrease in the activity of protective enzymes on the surface of the skin.
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Modern cosmetic products, as a rule, are aimed at eliminating the consequences of the main causes of skin atrophy: disruption of the antioxidant system, insolation, dehydration. The most effective means of skin rejuvenation are direct or indirect biological stimulators of the reparative processes of the dermis. In particular, these are hyaluronic acid, vitamins, protein solutions, micro and macro elements.
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The use of hardware cosmetology for the treatment of skin pathology is one of the best and most effective methods in aesthetic medicine and is increasingly taking a leading position along with invasive techniques. Unfortunately, not all hardware methods are comfortable: usually 8-10 sessions of the procedure are needed with an interval of 7-14 days, because after some devices, for example, laser peeling, the skin is injured, which requires a recovery period.
Also, procedures such as chemical peels are divided into superficial, medium and deep, according to the skin layer on which the effect occurs. With deep wrinkles, or with acne / post-acne, it is necessary to carry out a median or even deep peeling. Such damage to the skin will require significantly longer time for skin regeneration.
Benefits of skin electroporation
Therefore, more and more attention is paid to the transdermal effect on the skin. 2nd generation transdermal therapeutic systems include iontophoresis, sonophoresis, electrophoresis and ultrasound. Iontophoresis involves the use of an external electric field to transport a charged drug molecule through the skin. Among non-invasive methods, low-frequency ultrasound has shown good efficiency in the transport of various molecular compounds both in vivo and in vitro.
It has been proven that ultrasonic waves, by tearing the stratum corneum and causing opening of the pores, greatly facilitate the transdermal transport of various drug molecules.
Electrophoresis involves the use of a high-voltage millisecond pulse and is designed to create transit routes for large drug molecules in the stratum corneum. But an external high voltage pulse can cause serious damage to the skin.
The 3rd generation transdermal therapeutic system includes electroporation of the skin. During electroporation, a local rearrangement of the structure occurs in the bilayer lipid membrane, which leads to the appearance of circulating through water channels. The transport of low molecular weight ionized substances through these channels quantitatively exceeds that in electrophoresis and ultraphonophoresis by 4-10 times.
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Transdermal delivery provides a number of undeniable advantages over traditional methods. First of all, it is possible to avoid the primary passage of drugs through the gastrointestinal tract and the associated loads and transformations. Moreover, the non-invasive transfer of molecules is atraumatic and does not carry the risk of complications, for example, such as with traditional injection mesotherapy – pain, petechiae and hematomas, linear necrosis, infectious complications, etc.
Mechanism of rejuvenation and recovery by electroporation of the skin
Electroporation or aquaporation is an electrical breakdown of cells under the action of electromagnetic impulses to create pores. Thus, the transdermal delivery of the necessary substances occurs, even into the deep layers of the skin. Electrical impulses affect cell membranes, in particular, the linkage of lipids in the intercellular spaces, causing a chain of molecular changes, and these, in turn, form micropores - channels through which medical cosmetics penetrate. In this way, electroporation increases the permeability of the skin, in particular in the stratum corneum of the epidermis.
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The electroporation process is directed at the cells as they are the building blocks of the tissue. Temporary electroporation makes it possible to create open pores in the cell membrane of sufficient size to ensure the supply of necessary substances inside. An impulse acts on the cells, and when the membrane potential exceeds a certain threshold value, the cells in the membrane open and remain open for about 30 s. The membrane is destabilized by an electric field that uses electrostatic forces to gently transfer aqueous solutions into the membrane.
Under the action of an electric field, lipid molecules reorient themselves, creating hydrophilic pores. The creation of pores is due to the relatively weak nature of the hydrophobic-hydrophilic bond of the phospholipid bilayer. The lifetime of the pores is sufficient for the penetration of the selected substances into the cell. After the action of an electrical impulse, the pores in the membrane disappear.
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