In aesthetic medicine, there are many effective drugs aimed at solving ANTI-AGE problems. Partially, the problems of age-related changes in the skin, such as sagging, loss of elasticity, the appearance of small and medium wrinkles, can be solved with hyaluronic acid. This is a biorevitalization procedure, the effect of which is not only well known, but also proven by many clinical studies and satisfied patients, in which the quality and turgor of the skin changes. But in the arsenal of the ANTI-AGE doctor there is an equally effective procedure - bioregeneration with polynucleotides, read more about it at estet-portal.com.
Possibilities of polynucleotides in activation of skin cells
As Andrey Vaganov-Dashkov - anti-age therapy doctor, dermatovenereologist, certified specialist in injection techniques, scientific director of the Laskos training center, said, interest in nucleic acid as a drug arose a long time ago. Studies of its properties in various branches of medicine have been going on for more than 100 years. Publications about the special ability of nucleic acids to increase the overall resistance of the body began to appear in 1892. Gorbachevsky in 1883 and Morek in 1894 used nucleic acid to treat lupus. Chains of nucleic acids form polynucleotides.
Polynucleotides are rightly called the "molecule of life" because its capabilities are impressive.
Polynucleotides are able to simulate the immune response, DNA fragments force the reparative system of cells to work actively, helping to reduce the amount of photodamage products in cells.
In modern cosmetology, preparations with polynucleotides are widely used as one of the most powerful antioxidants.
Polynucleotides – it is deoxyribonucleic acid (DNA), the basic molecule that makes up the genome. Its mirror copy, but consisting of one chain, is ribonucleic acid (RNA). It is from RNA that the structures of future proteins are read, as from a matrix. The minimum information fragments of these nucleic acids are nucleotides consisting of a base, a sugar, and a phosphorus group. Nucleic acids play an important structural role in the cell, they are components of ribosomes, mitochondria and other intracellular structures.
With such wide possibilities of polynucleotides, the question arises: how safe are they? The answer is given by the work of foreign scientists. In some of them, it was shown that DNA is a sodium salt with a molecular weight of 500 kD. It does not carry genetic information, but has therapeutic activity. The highest therapeutic activity of the native sodium salt of DNA was found in the molecular weight range of 200-500 kilodaltons.
Peculiarities of action of polynucleotides used in bioregeneration procedures
The most popular methods of cosmetic treatment of the skin are bioregeneration and biorevitalization procedures.
The goals of bioregeneration and biorevitalization are similar, they are:
· restore skin hydration;
· increasing its elasticity and firmness;
· correction of gravitational ptosis;
· reduction in the severity of dermal and significant improvement in the condition of epidermal wrinkles;
· damage regeneration;
· reducing the severity of rosacea, enlarged pores, etc.
But the mechanisms of action on the cells of the dermis in active substances are different.
The mechanism of action of hyaluronic acid is to deeply moisturize the skin, activating the work of fibroblasts through the CD-44 receptor, followed by the production of collagen and elastin. The mechanism of action of polynucleotides is different.
Polynucleotides – it is a building block for DNA and RNA repair. Polynucleotides also restore the proper functioning of cell organelles, stimulate metabolic processes and cell proliferation.
By carrying out the biorevitalization procedure, we actually see an instant result after the procedure, followed by a visible improvement within a week. After the introduction of polynucleotides, we observe the result in a few days due to a more complex mechanism of action. The effect is longer and more stable. Polynucleotides increase the number of dermal structures more physiologically and cause a prolonged effect by activating their own functions of skin structures. The skin begins to produce its own young fibroblasts and keratinocytes, hyaluronic acid, self-healing occurs.
Polynucleotides bind free radicals, protect against the effects of UV rays. Also, polynucleotides can be successfully used on the scalp in the treatment of various types of alopecia. They can be used on various parts of the face without restriction, without fear of causing unwanted puffiness.
Examples of the use of preparations for revitalization and regeneration with polynucleotides
A classic example of a revitalizant is Z fill REFRESH (Zimmer, Germany) from Laskos. The preparation contains hyaluronic acid 18 mg / ml with a molecular weight of 3 ml Da. The drug is injected in a course of three procedures with an interval of 1 month. The injection technique is micropapular or bolus. We prick with caution in the periorbital zone, as we are afraid of excessive swelling.
In aesthetic medicine, the X-DNA preparation from the company Mesoestetic (Spain) has been successfully used for more than 20 years.
The uniqueness of this drug lies in the fact that we can combine it with other polyrevitalizing drugs to solve various aesthetic problems.
One example of a combination is the combination of X-DNA gel and NCTC-109. The combination with NCTC-109 expands the reparative capabilities of X-DNA due to enrichment with vitamins, minerals, amino acids. The protocol for the procedure is simple. We mix two preparations in a 1:1 ratio and pierce the required area using the micropapular technique (face, neck, décolleté, hands, etc.). The interval between procedures is two weeks, the number of procedures is from 5 to 7. We actually see the result of this procedure at the tip of the needle - pronounced lifting, improvement in skin color and texture, reduction in the number of fine wrinkles, and the depth of medium ones.
Summarizing the above, we can confidently speak about the need to have preparations with polynucleotides in the arsenal of every cosmetologist.
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