Perfect HA-based fillers: reference safety, ease of injection, maximum lifting, long-lasting effect

Age-related changes in the face – loss of elasticity and firmness, decrease in the level of skin hydration, loss of soft tissue volume, distortion of the contours and proportions of the face – the most frequent complaints of patients of aesthetic clinics. A convenient, safe and effective method for correcting the above defects is contouring with hyaluronic acid fillers. The HA preparation, which is selected based on the indications and characteristics of the product itself, improves skin quality, fills the lack of volume, tightens the skin and restores youthful contours to the face.

The exceptional ease of injection, maximum lifting and long-lasting effect of contouring in practice are demonstrated by Saypha (Croma) fillers from the official distributor TOTISPHARMA GROUP LLC,

A new generation of fillers based on hyaluronic acid Saypha – absolute safety, innovation and a wide range of indications
•  
Saypha FILLER – the most natural and aesthetic lip correction, a powerful weapon against wrinkles, folds and scars
Saypha VOLUME – optimal restoration of volumes
•  
Saypha VOLUME PLUS – maximum lifting and remodeling of facial contours
•  
Safety of contouring with fillers based on
• hyaluronic acid A new generation of fillers based on hyaluronic acid Saypha – absolute safety, innovation and a wide range of indications 

Croma Company – an expert in the development of products based on hyaluronic acid. The main, but not the only advantage of Saypha fillers, presented on the market by

the official distributor of

TOTISPHARMA GROUP, is the highest safety profile. Glass Syringe, Low BDDE Concentration, Strict Quality Standards and General Features – reasons why aesthetic doctors choose Saypha products.  Saypha's Next Generation HA Fillers Ease the Practitioner's Job and Reduce Risk to the Patient:

 

low pressure force when inserting – the latest innovation for patient comfort and safety, the conical shape of the plunger plug promotes uniform and smooth administration of HA;

 

• innovative design developed and tested by – awarded with Design Award 2017 iF; 
• proven safety of boron silicate glass, which is non-leaching and harmless, minimizes the risk of complications for the patient; 
• safe introduction – additional surface for gripping and resting, and a flat plunger for a secure position of the syringe in the hand; 
• visual orientation – easy and quick overview of the scale graduation on the syringe; 
• high patient comfort – less bruising and complications due to the ultra-thin-walled Terumo needle + TSK STERiGLIDE cannula. 
•  

The Saypha line of products gives the doctor the opportunity to work in

different areas of the face, effectively and long-term solving problems

:

presence of wrinkles;

loss of firmness and elasticity of the skin;
lipoatrophy;
morphological asymmetry;
volume deficit;
deformation of facial contours;
lack of volume and fuzzy lip contours.
•  

 

 

G Prime [G‘] G‘ is a rheological parameter that determines the density of HA gels. High G determines the volumizing capabilities of

HA gels.

Saypha FILLER – the most natural and aesthetic lip correction, a powerful weapon against wrinkles, folds and scars

Saypha FILLER

(with or without lidocaine) – preparation based on

cross-linked HA at a concentration of 2.3% (23 mg/ml), intended for injection into the middle and deep dermis, which remains in tissues for up to 9 months.    

Saypha FILLER – it is a

universal product

that can be used as a standalone treatment or in combination with other Croma products.

  Saypha FILLER is slightly softer than the other HA fillers in the Croma portfolio and is the optimal choice when ease of spreading and smooth transitions are required. 

Readings: 

correction of moderate and medium wrinkles and folds;

 

• lip augmentation; 
• facial lipoatrophy; 
• atrophic
scars;
•   morphological asymmetry. 
• Saypha VOLUME – optimal restoration of volumes
 

Saypha VOLUME

(with or without lidocaine) is a 2.3% (23 mg/mL)

cross-linked HA formulation intended for injection into the deep dermis or subcutaneous tissue. Time in tissues – 9 to 12 months.  Readings:

 

correction of deep wrinkles and folds;

 

• restoration of facial volumes; 
• reconstructive therapy for facial lipoatrophy, atrophic scarring or morphological asymmetry. 
• Saypha VOLUME has been clinically proven to be effective and safe in Croma.
 

 

Studies with HA fillers show similar treatment outcomes in people of different ethnicities or skin types. Saypha® VOLUME

is well tolerated and provides long lasting results

.

  Read also:

Case studies of performing the Full Face technique to correct age-related changes in patients with different types of aging

  Based on GAIS scores, the appearance of the nasolabial folds showed a trend of improvement in 100% of patients at days 14, 30, and 90, and in 97.9% of patients at days 180 and 270. For the majority of patients, the investigators rated the appearance of nasolabial folds based on GAIS as "significantly improved"; in all visits

compared to day 0.

Saypha VOLUME PLUS – maximum lifting and remodeling of facial contours

 

Saypha VOLUME PLUS

(with lidocaine) – filler based on

cross-linked HA at a concentration of 2.5% (25 mg/ml), intended for deep dermal, subcutaneous or supraperiosteal injection. The drug is in the tissues for 9–12 months.  Follow us on

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!  Readings:

 

reconstructive treatment of facial lipoatrophy;

 

• correction of midface volume deficit; 
• shaping the contours of the face. 
Maximum lifting

 

Saypha VOLUME PLUS has shown maximum elasticity

compared to other volumizing dermal fillers. The drug has the highest G Prime [G'], which determines the bulk capacity of HA gels. The physico-chemical characteristics of individual commercially available fillers have been studied by Croma Research & Development.

 

The Saypha VOLUME PLUS formula, combined with the new Croma syringe, allows

to predict the result and smoothness of the injection

, causing less tissue resistance and guaranteeing patient and doctor comfort and complete satisfaction with the result of the procedure.

  Saypha VOLUME PLUS integrates perfectly into tissues, while providing reliable structuring and lifting.

Duration of volumizing and contouring effect

 

CROMA's in vitro enzymatic degradation study using Saypha®; VOLUME PLUS, showed objectively greater drug stability compared to other HA-based fillers. 

 

In addition, resistance to enzymatic degradation makes it possible to predict a long-term, lasting effect in patients.

The Saypha line of products, in addition to fillers for contour plastics, includes a new

generation biorevitalizant Saypha RICH.

Safety of contouring with hyaluronic acid fillers

The safety and results of contouring with HA fillers depend not only on the quality of preparations and the skill of the practitioner. An important condition before carrying out any procedure with the use of Saypha fillers is

taking an anamnesis

. So, at the consultation stage

it is important to know:  is the patient taking medication (painkillers, anticoagulants, antibiotics, sedatives, sleeping pills);

 

• whether the patient suffers from cardiovascular (high blood pressure, arrhythmias, angina pectoris) or other disorders; 
• does the patient have intermittent nosebleeds, bruising after light touching; 
• whether the patient has a bleeding disorder; 
• is the patient allergic (if yes, to what); 
• whether the patient has hypersensitivity to local anesthetics (particularly lidocaine), patches or latex; 
• Does the patient often suffer from infectious diseases (if so, which ones); 
• whether the patient has a predisposition to keloid scarring; 
• whether the patient suffers from autoimmune diseases (scleroderma, systemic lupus erythematosus, autoimmune thyroiditis, diffuse toxic goiter); 
• does the patient smoke; 
• does the patient periodically have herpes (if yes, in which areas); 
• whether the patient was previously anesthetized; 
• whether the patient is pregnant or lactating; 
• has the patient ever undergone aesthetic procedures with contouring products (if so, when and what substance/product was used, did the procedure cause any complications); 
• whether the patient has had surgery or tooth extractions in the past 6 months; 
• whether the patient has a history of anaphylactic shock. 
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  It is also important to warn the patient that redness, swelling and soreness may occur at the injection sites after contouring. These reactions usually go away on their own. 

The duration of the filler may vary

depending on the body's predisposition to the breakdown of hyaluronic acid, the type and method of injection. Correction is possible no earlier than 2 weeks after the administration of the drug. Re-introduction is possible after the expiration of the biodegradation period of the previously administered drug (9-12 months).

  Saypha (Croma)

fillers from the official distributor

TOTISPHARMA GROUP – easy-to-use preparations with the highest safety profile, which provide a visible and long-lasting effect of contouring. Saypha – drugs trusted by aesthetic doctors all over the world!  More interesting videos on our

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