It is believed that 3-hydroxy-3-methylglutaryl-coenzyme A-reductase inhibitors ("statins") can not only lower cholesterol levels, but also have other important effects. These pleiotropic effects of statins include beneficial effects on systemic inflammation, endothelial function, and oxidative stress.
It has been hypothesized that statins may reduce the risk of diabetes; instead, accumulating evidence suggests that statin use may increase the risk of developing type 2 diabetes.
In the estet-portal.com article, you can read in detail the results of the analysis of data from the Diabetes Prevention Program (DPP), which studied the effect of statins on a cohort of overweight and obese people at high risk of developing diabetes. diabetes.
Description of the Diabetes Risk Study Sample
At 27 US clinical centers, 3234 participants of both sexes were recruited, approximately 20% of whom were ≥60 years of age. Eligibility criteria included age ≥25 years, body mass index (BMI) ≥24 kg/m2, as well as fasting plasma glucose levels of 95 to 125 mg/dl (5.4-6.9 mmol/l) and impaired glucose tolerance (impaired glucose tolerance - IGT) (2 hours after loading 75 g glucose - 140 - 199 mg / dl (7.8-11.0 mmol / l) blood glucose).
Fasting plasma glucose, insulin, glycated hemoglobin (HbA1c), and lipid profiles were measured at the Central Biochemistry Laboratory (University of Washington, Seattle, Washington, USA).
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Statins as a universal panacea
The attending physician individually prescribed a dose of statins in order to correct the lipid profile. After 10 years of follow-up, the cumulative incidence of statin use before diagnosis of diabetes mellitus was similar in the treatment groups: 35% in the placebo group, 37% in the metformin group, and 33% in the dosed exercise group (p = 0.36).
The most commonly used statins were simvastatin and atorvastatin (40% and 37% respectively), followed by lovastatin (9%) and pravastatin (8%). The prevalence of statin use increased over time and was significantly higher after the diagnosis of diabetes.
To evaluate whether statin efficacy was associated with risk of diabetes, the authors grouped data on statin use into the "low efficacy" category. (pravastatin, lovastatin, fluvastatin, 19%) and "high potency" (atorvastatin, simvastatin, rosuvastatin, cerivastatin, 81%). The risk of diabetes did not depend on low and high statin activity.
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The other side of the statin coin
Statin use was associated with significantly less favorable changes in fasting glucose, 2-hour post-exercise glucose, HbA1c, and BMI. In the dosed exercise group, the insulinogenic index decreased with the use of statins compared with an increase without the use of statins (p = 0.013).
A decrease in insulin secretion has been observed among patients taking statins.
Overall, statin-treated participants appeared to be relatively resistant to the beneficial effects of metformin and metered exercise on obesity and beta-cell function.
This report is the first to evaluate the association of a statin with diabetes in a randomized clinical trial designed to carefully determine the incidence of diabetes in patients at high risk of developing diabetes. In this analysis, statin use was associated with a clear increase in diabetes risk of almost 30%.
Increased risk of diabetes or prevention of atherosclerosis
For individual patients, the potential increase in the risk of diabetes mellitus must be carefully balanced against the possibility of a reduction in the risk of myocardial infarction, stroke, and cardiovascular death. However, patients at high risk of diabetes mellitus who are prescribed statins for the prevention of cardiovascular disease should be monitored and a healthy lifestyle should be maintained.
Patients at high risk of developing diabetes should be monitored during statin therapy.
Thank you for staying with estet-portal.com. Read other interesting articles in the "Cosmetology" section. You may be interested in Complications caused by drug interactions
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