Stimulation of fibroblasts and collagen synthesis is an effective way to rejuvenate the skin

Over time, the skin becomes thinner and its barrier function and natural UV protection gradually decrease.

Collagen mass and flexibility are also starting to decline (about 1% per year), and collagen is one of the most important structural proteins of our skin.

Find out in the article on estet-portal.com what role does collagen play in the process of skin rejuvenation and what modern methods of fibroblast stimulation exist in cosmetology to increase regenerative potential skin cells.

• The structure of collagen and its role in facial skin rejuvenation
• Collagen biosynthesis in the skin
• Methods of stimulating collagen biosynthesis in the process of skin rejuvenationand

The structure of collagen and its role in facial skin rejuvenation

Collagen − the main structural protein of the skin, which is found mainly in the dermis (more than 70% of dry skin and 25% of all proteins).

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Collagen − it is a fibrillar protein, which differs from others in a number of features of its composition and structure.

Primary Structure. The peptide chain that is part of collagen contains about 1000 amino acid residues, of which 33% is glycine, about 21% − proline and hydroxyproline, 11% − alanine and only about 35% − all other amino acids.

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The papillary dermis contains various types of collagen:

• collagen fibers of the papillary layer are formed by type 1 collagen;
reticulin fibers
• of the papillary layer contain type 3 collagen;
basement membrane
• − type 4 collagen; directly below the epidermis is a mesh of
anchor fibers
• , which is formed by type 7 collagen.
Anchor fibers stabilize the skin structure, strengthening the connection of the epidermis with the underlying connective tissue, which naturally plays a big role in

rejuvenation of the facial skin

and providing an even relief without the risk of formation of wrinkles and creases. Biosynthesis of collagen in the skin

The process of

collagen synthesis

can be divided into intra- and extracellular stages:

1. Intracellular stage.

The first stage - the synthesis of

preprocollagen

occurs in fibroblasts on ribosomes associated with the membranes of the endoplasmic reticulum.  

2. Extracellular stage.

In the extracellular environment, under the action of proteolytic enzymes (procolagen peptidases), terminal polypeptides (

propeptides

) are cleaved off.

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Hypodermis

, or subcutaneous tissue, located under the dermis. It consists of adipose and connective tissues. It is characterized by fat lobules formed by

adipocytes

(adipose tissue cells).

Adipocytes

are spherical, surrounded by collagen fibers and blood capillaries.

The collagen fibers of the hypodermis

are attached to the fascia of the muscle bundles and provide a strong bond between the skin and underlying tissues. Intensive

collagen synthesis

takes place during wound healing. 

deficiency in the body of ascorbic acid and iron; & nbsp;

• low oxygen partial pressure in the wound.
All of the above factors are necessary for the activity of proline and lysine hydroxylases.

Excess formation of

collagen fibrils

is observed in a number of connective tissue diseases. With age,

the ratio of collagen types

in tissues changes, the number of cross-links increases, labile cross-links are replaced by stable ones, which makes collagen fibrils rigidity and fragility.

th. Structural changes in collagen in the skin lead to a decrease in its elasticity and the formation of wrinkles.

Methods of stimulating collagen biosynthesis in the process of skin rejuvenation

At the moment, one of the most effective preparations is presented on the aesthetic medicine market, which allows for skin rejuvenation in three dimensions, stimulating its regeneration and collagen synthesis −  

NITHYA

collagen powder for injections (the official distributor is «Beauty Magic»).

This is the most purified and natural product that does not cause allergies.  Injected into the skin with special syringes, collagen acts on fibroblasts, causing them to promote skin regeneration and secrete natural collagen.

NITHYA collagen injections are suitable for skin rejuvenation not only on the face, but also on the body, contributing to greater skin density in other areas, as well as making scars of various origins less noticeable.

This therapy guarantees a significant improvement in skin density, elasticity and texture, and a reduction in wrinkles.

For a long lasting and noticeable effect, a course of 3-4 treatments at two-week intervals is recommended. If necessary, the course should be repeated after three months.

Indications for NITHYA Collagen Injections:

reduction of signs of aging (face, neck, décolleté, skin of hands and body);
increased collagen content in the skin;
preparation for plastic surgery, peeling, laser procedures or for preventive purposes after them;
scar reduction (acne, stretch marks and other scars).

 

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NITHYA Collagen Injections Beauty Magic Company — it is a simple but very effective way to rejuvenate the skin, improve its texture and elasticity.