Влияние инфицирования Хеликобактре пилори на течение псориаза и экземы

The discovery of such an infectious agent as Helicobacter pylori significantly influenced the understanding of the etiology and pathogenesis of many diseases. Modern studies show that this pathogen acts not only as a local damaging factor, but is also capable of indirectly affect the processes of the systemic inflammatory response.

At estet-portal.com read more about how Helicobacter pylori infection affects the course of dermatological diseases such as psoriasis and eczema.

Helicobacter pylori: the impact of infection on the clinical course of psoriasis and eczema

Analysis of the course of the disease in patients with & nbsp; psoriasis and eczema who had a concomitant Helicobacter pylori infection. In patients with a mild course of skin disease, the frequency of infection with a pathological agent did not exceed the values ​​of the control group.

In cases of severe psoriasis, the infection rate of Helicobacter pylori was more than 70%.

These studies indicate the influence of chronic infection with Helicobacter pylori on the frequency of recurrence of dermatological diseases such as psoriasis and eczema, as well as on the severity of their course.

Helicobacter pylori:
•    indicators of the influence of Helicobacter pylori on the course of eczema and psoriasis;
•    therapy of psoriasis and eczema, taking into account the effects of Helicobacter pylori;
•    Helicobacter pylori eradication: improvement of psoriasis and eczema.

Indicators of the influence of Helicobacter pylori on the course of eczema and psoriasis

The processes underlying the extragastric pathology associated with Helicobacter pylori are not fully understood. 

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Three mechanisms have been suggested that lead to H. pylori associated diseases:
•    interaction of bacteria and  mast cells with  subsequent release of mediators;
•    Helicobacter pylori as a complete antigen causes allergic reactions in the host organism;
•    bacteria reduce the barrier function of the intestine, contributing to the entry of allergens into the bloodstream.
Special attention is paid to the activation of the inflammatory process by the bacterium, during which cytokines and inflammatory mediators are released, which causes sensitization of the body.

Therapy of psoriasis and eczema, taking into account the effects of Helicobacter pylori

It was proposed to add anti-helicobacter therapy to the scheme of complex treatment of psoriasis and eczema. The patients were also divided into two groups, the first half of which underwent eradication of the pathogen, and the second half — no. In the course of treatment, in patients of the first group, the clinical signs of dermatosis regressed faster and to a greater extent. All patients experienced a decrease or disappearance of itching, as well as normalization of sleep. Moreover, in patients of this group, appetite improved, manifestations of asthenovegetative and dyspeptic syndromes decreased. Patients who were not treated with Helicobacter pylori did not experience such improvements.

Eradication of Helicobacter pylori: improvement of the course of psoriasis and eczema

Thus, the presence of Helicobacter pylori infection in patients with psoriasis and eczema is an important pathogenetic factor that negatively affects the course of the disease.

Complex therapy of psoriasis and eczema, including the Helicobacter pylori eradication scheme, has a quick, long-term and more pronounced effect in the treatment of these diseases.

Prescribing antihelicobacter drugs for psoriasis and eczema in patients with concomitant pathology of the gastroduodenal zone contributes to a rapid improvement in the quality of life of patients, due to a significant reduction in the severity of clinical symptoms.

See also: Botulinum toxin injections for gastrointestinal cancer and obesity

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