Dosed inflammation of the skin of the face: due to which rejuvenation is achieved

For a long time, experts believed that during anti-aging procedures, the most pronounced effect is achieved due to the factor of skin damage. The inflammatory reaction was usually considered an inevitable concomitant phenomenon of the damaging effect, which can only lead to complications after the procedure. However, today, recent studies clearly show that dosed inflammation of the skin of the face can have a strong morphological rejuvenating effect, even more significant than  actual skin damage. Due to what mechanisms this happens, read on estet-portal.com.

Stages of the inflammatory response and features of skin restoration

An inflammatory reaction becomes an inevitable consequence of the damaging effects on the skin during the cosmetic procedure – for example, such as laser resurfacing, chemical peeling. However, as it turned out in the course of research, inflammation of the skin of the face does not always directly correlate with the depth of damage, while it correlates with the reactivity of the skin and the properties of the damaging agent.

It depends on how the inflammatory reaction proceeds after the procedure, how quickly and completely the restoration of the skin will take place, how effectively it regenerates, which means – what will be the final result of the anti-aging procedure.

The inflammatory reaction that develops to any skin injury goes through certain stages.

Alteration. After the skin has been damaged during a cosmetic procedure, lysosomal enzymes are released, which have an additional damaging effect, as well as superoxide anion radicals and peroxides. These elements are designed to clean the area injured by the procedure as much as possible from damaged cells, damaged collagen and elastin fibers, and various extracellular structures. At the same time, old defective cells and collagen fibers are destroyed, which interfere with the correct, effective healing of the skin. This stage of inflammation of the skin of the face lasts about a day.

Exudation. At the second stage of the inflammatory reaction that occurs after the cosmetic procedure, anti-inflammatory cytokines are released, phagocytes, immunocompetent cells, and then fibroblasts move to the area of ​​skin damage. At the same time, local edema develops due to increased permeability of the vascular walls. Metalloprotease and hyaluronidase are activated, phagocytosis is stimulated. The result of these processes is the cleansing of the skin damage zone from deformed cells, matrix elements and collagen fibers, while the inflammation zone of the facial skin does not expand.

The reactions occurring in the area of ​​inflammation stimulate the following important processes:

• intensive synthesis of hyaluronic acid,
• formation of new elastin and collagen fibers,
• growth of the microvasculature in the damaged area.

The duration of the second stage of the inflammatory reaction depends on the depth of the skin damage.

Proliferation. At the third stage of the inflammatory process, the processes of activation and proliferation of fibroblasts are intensified, components of the extracellular matrix, new collagen and elastin fibers are intensively synthesized. It is very important that at this stage the formation of all components at the site of inflammation proceeds correctly.

Matrix molecules – proteoglycans, mucopolysaccharides – synthesized within a few days, they form a free three-dimensional space without requiring a clear orderly arrangement. New vessels grow into this space, fibroblasts are directed. Further, in this space of the matrix, the formation of collagen fibers begins, but for them it is already very important to position themselves correctly, weaving into a strong multi-level network.  If for some reason the collagen fibers have formed into a tangled ball, then a dense inelastic structure will develop in this place – for example, a hypertrophic scar. When the inflammation heals properly after skin damage, then in this place the collagen fibers are intertwined into a strong, but at the same time mobile and elastic mesh.

For proper skin healing – fast and with high-quality collagen mesh – it is necessary that there is a lot of hyaluronic acid in the matrix.

It forms a special gel-like structure in which fibroblasts can easily and correctly form collagen fibers, placing them in the form of a strong elastic mesh. The duration of the third stage of healing of the inflammatory process is about a month, sometimes more.

Thus, in order to achieve the best effect after a rejuvenating cosmetic procedure associated with skin damage, the doctor must control the inflammation of the facial skin as much as possible in order to achieve high-quality and fast healing.