Возможно ли достичь ремиссии сахарного диабета 2 типа при снижении веса

The Lancet has published the results of the DiRECT, a two-year, open-label, randomized, cluster trial, on the effectiveness of primary care weight management interventions for remission of type 2 diabetes.

In the article estet-portal.com you can read in detail the conclusions regarding the relationship between weight loss and high blood sugar.

New non-pharmacological management of type 2 diabetes

will enable patients to go into remission for a long term. Read the article about the degree of weight loss required. Excess weight as a factor in hyperglycemia

DiRECT — is an open-label, randomized, cluster-controlled trial in primary care settings in the UK.

The study included people aged 20-65 years, with type 2 diabetes for less than 6 years, with a body mass index (BMI) of 27-45 kg/m2 and did not receive insulin between July 25, 2014 and August 5 2016.

How to prescribe hormones for obesity Patients were discontinued antidiabetic and antihypertensive drugs, put on a diet (825-853 kcal per day for 12-20 weeks), and then received structured support to maintain weight loss.

Comparative outcomes analyzed at 24 months showed weight loss of at least 15 kg and diabetes remission, defined as HbA 1c less than 6.5% (48 mmol/mol) after discontinuation of antidiabetic drugs at baseline (remission was defined as 12 and 24 months).


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The main group consisted of 149 participants. At 24 months, 17 (11%) intervention participants and 3 (2%) control participants had a weight loss of at least 15 kg (p = 0.0023). Fifty-three (36%) participants in the intervention and five (3%) participants in the control group were confirmed to have diabetes in remission (p<0.0001).

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Adjusted mean difference between control and treatment groups for weight change was -5.4 kg (p < 0.0001) and for HbA 1c was -4.8 mmol/mol (p = 0.0063) , despite the fact that only 51 (40%) of 129 patients in the intervention group used antidiabetic drugs compared to 120 (84%) of 143 in the control group.

In a subsequent analysis of the entire study population, from the group of participants who lost at least 10 kg (45 out of 272 participants), 29 (64%) achieved remission. Of these, 36 (24%) of the 149 participants in the intervention group lost at least 10 kg.

DiRECT has confirmed diabetes remission after 24 months for more than a third of patients.

Sustained remission was associated with the degree of weight loss.

Thank you for staying with estet-portal.com. Read other interesting articles in the "Endocrinology" section. You may be interested in

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