Acne is one of the most common skin diseases and can occur in any person, regardless of gender and age. Acne usually appears in large numbers during adolescence, but often it can also occur in older age. There are many causes of acne. It is believed that during adolescence, the appearance of acne is caused by hormonal changes in the body, however, its occurrence can also be caused by malnutrition, heredity and other causes. Acne can manifest differently for everyone. Acne rashes can appear not only on the face, but also on the back or upper chest, where the largest number of sebaceous glands are located.
Find out in the article on estet-portal.com about the features of the use, indications and contraindications of systemic retinoids for the treatment of acne.
- Systemic retinoids for acne treatment
- Side effects of systemic retinoids in acne treatment
- The role of diet in acne treatment
Systemic retinoids for acne
Isotretinoin − systemic retinoid, which is effective in the treatment of acne in patients with severe forms of the disease. Isotretinoin contributes to the normalization of epidermal differentiation, inhibits the production of sebum by 70%, and has an anti-inflammatory effect.
Follow us on Instagram!
Acne treatment with isotretinoin is initiated at a dose of 0.5 mg/kg/day for 4 weeks, then gradually increased as tolerated until a cumulative dose of 120*150 mg/kg is reached. The use of the drug for the treatment of acne in low doses (0.25-0.4 mg / kg / day) can be characterized by the same effectiveness, but remission in such cases is shorter. For some patients with acne, one course of treatment with isotretinoin is sufficient to achieve complete remission.
The need for a second course of isotretinoin acne treatment is more common in younger patients and women.
Side effects of systemic retinoids in acne treatment
Isotretinoin − teratogenic drug, therefore, before starting acne treatment, it is necessary to make sure that the patient is not pregnant (two negative pregnancy tests) and advise her on further contraception.
Acne treatment: efficacy and safety of topical antibacterial agents
Basic laboratory examination before starting acne treatment with isotretinoin includes general and biochemical (determination of cholesterol, triglycerides, liver transaminases) blood tests. Pregnancy tests, as well as lipid profile and liver enzyme monitoring, should be repeated monthly during acne treatment while the dose is being titrated. After reaching the cumulative dose of isotretinoin with normal levels of liver enzymes, lipid profile and complete blood count, laboratory monitoring can be stopped.
Other side effects associated with the use of isotretinoin in the treatment of acne include dry skin, lips and eyes, myalgias and severe headache. If treatment is accompanied by severe headache, decreased night vision and mental disorders, the use of isotretinoin should be discontinued immediately.
Distorted relief: microneedle therapy and PRP plasma in post-acne treatment
When isotretinoin is used in the treatment of acne, there is a high risk of abnormal healing and hyperproduction of granulation tissue after cosmetic procedures (eg, dermabrasion, laser skin resurfacing, etc.). Cosmetic procedures that are accompanied by trauma to the skin should be delayed for 1 year after completion of treatment with isotretinoin.
The role of diet in acne treatment
Fulton et al. studied how daily candy bar consumption affects acne in teenagers but found no correlation. However, studies conducted in 2012 in Italy, and in 2016 in Pennsylvania, showed that the use of "harmful" food (potato chips, sugary soft drinks, etc.) negatively affects the skin condition and is a trigger of acne exacerbation.
Androgens and acne: the pathophysiology of the interaction in the beauty arena
At the same time, the use of skimmed milk, compared with milk of normal fat content, contributes to a decrease in the number of acne rashes (especially among adolescents and young people). This is probably due to the normal fat content of whey protein in milk, which is a trigger for acne exacerbation.
A study conducted in Australia in 2007 demonstrated that following a low-glycemic load diet (low-GI diet) improved skin conditions in patients with acne.
Only maximum adherence to all recommendations will help get rid of acne. Self-medication can lead to complications such as: scars, large scars that remain for life, abscesses, etc.
Investigation of the role of the leading causes of acne in the development of the disease
Share:
Add a comment