What can redermalization against the skin aging process

Skin aging process — a natural, natural phenomenon, however, discovering the first signs of age-related changes on the face, we try to fight them. After all, to keep youth and attractiveness as long as possible — understandable and understandable desire of most people. Among the methods for correcting age-related changes, redermalization shows a good effect. The use of preparations of the Hyalual line for this procedure makes it possible to realize the impact on various pathogenetic mechanisms of skin aging. Galina Naumchik, PhD, dermatologist, cosmetologist, director of the School of Injection Technologies of Professor Yutskovskaya, told estet-portal.com readers more about the features of the preparations and their composition.

Why cosmetic care is important in slowing down the skin aging process

For a long time, scientists have been trying to understand the causes of aging, offering various theories. Genetics, biochemistry, biology, medicine, gerontology – comprehensive studies in these disciplines allow a more complete study of the mechanisms of involutional changes in the human body. Skin aging is only one of the elements of the aging of the body as a whole.

Skin aging has been proven to start immediately after puberty, at 35-50 years of age - it becomes more noticeable and lasts until about 60 years of age, after which a relatively stable period begins. Main aging factors:
•   genetically programmed changes affecting almost all layers of the skin;
•   decrease in the synthesis of hormones in the body (growth hormone, testosterone, DHEA (dehydroepiandrosterone) and melatonin are produced in sufficient quantities only until the age of 20, and they are indispensable for physical health and cell regeneration);
•   ultraviolet promotes the formation of free radicals that negatively affect the structure of skin cells, changing the mechanisms of cellular repair.<

There is no unequivocal opinion about what aging is, but it is already clear that it is caused by the accumulation of defects in DNA molecules, the growing disorganization of physiological processes in the cell, which, in the end, lead the body to death.

The sum total of these changes is:

•   a decrease in the number of Langerhans cells that control the immune response (violation of local skin immunity, slow wound healing, the appearance of foci of irritation);
•   weakening of the functioning of the sebaceous and sweat glands (deterioration of the water-lipid balance of the skin);
•   a decrease in the number of blood capillaries (impaired microcirculation), fibroblasts (weakening of the synthesis of elastin collagen) and melanocytes (increased sensitivity to ultraviolet radiation, photoaging),
•   decrease in the rate of cell division of the basal layer (slower renewal and thinning of the epidermis);
•   decrease in enzyme activity,
Only today, when science has been able to understand and explain many processes, it can be confidently stated that the competent and timely use of cosmetic care techniques in combination with a healthy lifestyle can, if not stop the process of biological skin aging, then at least make it manifestations are less pronounced.

Complex preparations with HA – an important factor in slowing down the skin aging process

The method of physiological repair of the extracellular matrix of the dermis by intradermal injection of high molecular weight hyaluronic acid preparations is called biorevitalization. For the first time the term "biorevitalization" was introduced in 2001 by Professor Di Pietro (Italy) with co-authors, who proposed a technique for intradermal injections of hyaluronic acid preparations in order to restore the intercellular substance and water balance. They determined that at the first stages of wound healing, a significant amount of hyaluronic acid accumulates on the damaged surface, which serves as a starting point for further tissue repair. By increasing the concentration of native hyaluronic acid in the skin using intradermal injections, Italian experts concluded that

Hyaluronic acid preparations replenish the loss of moisture. But today, combinations of substances that have a more active and complex effect on the pathogenetic links of aging are in demand. The composition of such preparations, in addition to hyaluronic acid, includes trace elements, amino acids, antioxidants, vitamins, growth factors. New designations have been introduced for them: redermalizants, bioreparants, biorestructuring agents, regenerants, biostimulants, polyrevitalizants.

Drugs in which active substances are combined can be called improved "generation"; biorevitalizants that can solve complex aesthetic problems.

Main substances used in combination injectables:

•    hyaluronic acid;

•    micronutrients: zinc, copper, etc.;

•    antioxidants: glutathione, alpha-lipoic acid, N-acetyl-L-cysteine, succinic acid, etc.;
•    amino acids: isoleucine, arginine, lysine, glycine, valine, proline, arginine, etc.;
•    alcohols: mannitol, glycerin;
•    vitamins: C, E, A, I, B, etc.;
•    polynucleotides;
•    synthetic analogs of peptides;
& bull;    growth factors.

Combined injectable drugs must be both effective and safe, so the requirements for them are quite high:
•    permission to use;

•    Proven Effectiveness;

•    no mutagenic effect;
•    minimum number of allergic reactions;
•    no toxicity;
•    bacterial safety;
•    compatibility with other cosmetic procedures;
•    minimum side effects.

An important factor for a cosmetic product – this is the optimal ratio «price– quality".

In our opinion, one of the drugs that meet the declared parameters is the original combined

preparation Hyalual

, which, in addition to hyaluronic acid, includes sodium succinate.

Succinate, being a substrate in the Krebs cycle that occurs in mitochondria, directly affects the production of ATP, acts as a regulator of physiological and biochemical processes, and activates tissue respiration. In addition, sodium succinate has powerful antioxidant properties.

Comparing the properties of sodium succinate and hyaluronic acid, we conclude that it is succinate that is a strategically important component in complex anti-age therapy and has a much greater effect on the endogenous synthesis of hyaluronic acid and collagen fibers than hyaluronic acid. This is due to a pronounced effect on the mitochondria of fibroblasts. Also, succinate stimulates the proliferation of fibroblasts much more strongly and provides a much more powerful effect on skin cells, being an indispensable source of their vital activity. At the same time, the active combined effect of hyaluronic acid and succinate directly on the dermis makes it possible to characterize the effect of the drug by the term "redermalization".

Thus, the use of preparations of the Hyalual line makes it possible to realize the impact on various pathogenetic mechanisms of skin aging and achieve a powerful complex anti-age effect from revitalization.