Amino acids and hyaluronic acid: perfect synergy for youthful skin

Currently, cosmetologists can offer their patients a wide range of effective anti-aging treatments. Replenish missing volumes, correct ptosis, eliminate pigmentation – this and much more can be achieved with the help of modern aesthetic techniques. Hyaluronic acid injections to improve the quality of the skin have been successfully used for quite a long time, but unfortunately, they do not always give a 100% result. This situation can be changed by combining hyaluronic acid with collagen synthesis activators, which can be amino acids.

Dermatologist Olga Olshanskaya spoke about the main advantages of this unique combination, as well as about the peculiarities of using JALUPRO® and JALUPRO®HMW preparations with amino acids and hyaluronic acid in an exclusive interview for estet-portal.com.

What are the main causes of visible signs of skin aging

We all know that the skin, like the entire human body, ages. The main signs of aging that our patients pay attention to most often – this is a decrease in skin tone and elasticity, and as a result, a change in the clarity of the oval of the face, the appearance and aggravation of wrinkles and folds. If we talk specifically about these signs of fading, then it must be remembered that this is a visible consequence of a decrease in the quality of the middle layer of the skin – dermis, manifested in a decrease in the content and change in the quality of collagen, hyaluronic acid. This is one of the main causes of aging. And the essence of most cosmetic anti-age procedures aimed at improving the quality of the skin is to stimulate the synthesis of endogenous collagen and hyaluronic acid, which can compensate for changes in the relief and tone of the skin, increase its elasticity.<

What role do amino acids play in skin-improving products?

Collagen – it is a protein molecule, and in order for it to be synthesized by a fibroblast, it is not enough just to stimulate it. We need free amino acids in the skin at the moment, which are the building blocks for collagen.

The structure of collagen is very specific and it mainly includes repeating sequences of amino acids: glycine, proline, lysine. In case of a lack of these amino acids, even active stimulation of collagen production will not lead to its full formation.

In addition, amino acids have been found to be regulators of collagen synthesis. The fact is that in the skin it is constantly being updated: the "old" broken down into amino acids, and a new one is synthesized. Increasing the concentration of free amino acids in the dermis – degradation products of collagen, affects the synthetic activity and proliferation of fibroblasts, ensures their positive chemotaxis to the site of increased concentration of amino acids, reduces the rate of degradation of existing collagen.

Accordingly, the exogenous introduction of collagen amino acids into the skin is perceived by cells as a signal for its synthesis. The effect of JALUPRO® and JALUPRO®HMW preparations used in cosmetology practice is based on this.

Tell us about JALUPRO®    JALUPRO®HMW. What are their main advantages?

JALUPRO®  and JALUPRO® HMW (Professional Dietetics, Switzerland) is represented in Ukraine by

Innovaesthetic. Their main feature is the combination of hyaluronic acid with an amino acid functional cluster (ROS). ROS is a complex of amino acids L-lysine, L-proline, L-leucine and glycine.

The key to the effectiveness of ROS is a certain ratio of amino acid concentrations in its composition. In addition, the optical isometry of molecules is fundamental: the use of L-isomers ensures maximum bioefficiency and recognition.

This is what makes ROS unique, being both the most biocompatible substrate and a trigger for collagen synthesis. JALUPRO® range represented by two preparations: JALUPRO® itself, represented by a combination of amino acids with low molecular weight hyaluronic acid (200 kDa) at a concentration of 1% in a volume of 3 ml and JALUPRO®; HMW from

Innovaesthetic, which combines amino acids with high molecular weight hyaluronic acid (1200-1400 kDa) at a concentration of 2%, the volume of the drug is 2.5 ml.

In what cases is the use of JALUPRO® preparations indicated? and JALUPRO® HMW with amino acids and hyaluronic acid?

The indications for the use of these drugs are very diverse. With a mild degree of manifestations of photo- and chronoaging of the skin, the base JALUPRO® is the drug of choice, and with moderate and severe manifestations, JALUPRO® is recommended; HMW with prolonged stimulation effect.

JALUPRO® and JALUPRO®HMW preparations are recommended for preparing the skin for cosmetic procedures that require rehabilitation (peelings, laser exposure, surgery), since amino acids increase the speed of reparative processes occurring in the skin.

Improve the quality of the skin of the body – a separate line of practice for a cosmetologist, where the use of JALUPRO® and JALUPRO® HMW is also expedient. It should be noted a good clinical effect on striae. When working with the skin of patients who have had acne, JALUPRO® has a pronounced effect on the correction of post-inflammatory elements, hypotrophic scars. The course of treatment varies from 4 to 6 procedures, depending on the indications. The interval between them for the JALUPRO® preparation; is 1-2 weeks, for JALUPRO® HMW, which has a prolonged action – 2 weeks.