Fillers based on calcium hydroxyapatite: predictable and long-term results of injection facial correction

In order to get predictable, natural and long lasting results of injectable facial enhancement, it is important to choose the right preparation. Hyaluronic acid, which is often used for contouring, due to its high hydrophilicity, can cause swelling, which is extremely undesirable for patients with deformative-edematous type of aging. In this case, it is advisable to use a filler based on calcium hydroxyapatite. The ideal solution – filler Facetem S from the official distributor TOTISPHARMA GROUP. The drug provides a beautiful and long-term effect – volume, lifting and smoothing of wrinkles, including by stimulating the synthesis of own collagen.

In the estet-portal article.

• Composition and safety of Facetem S calcium hydroxyapatite filler
Key Features of the Facetem S Filler
•  
• Mechanism of action and possibilities of Facetem S
Indications, benefits and reviews of
• Facetem S Composition and safety of Facetem S calcium hydroxyapatite filler
 

Calcium hydroxyapatite is completely biocompatible and safe as it is one of the components of bone tissue and teeth. GAK in 1995 FDA approved

as a completely safe excipient. 

Facetem S

contains rounded HAA microspheres suspended in an aqueous medium of carboxymethyl cellulose. Their diameter of 25 & ndash;45 microns is the safest, since particles of this size do not penetrate into the circulatory and lymphatic systems, and also do not cause pathogenic fibrosis.  Dermal filler Facetem S – a safe drug that does not cause an inflammatory reaction in tissues, does not migrate and is completely eliminated from the body over time. 

 

Safety of Facetem S confirmed by:

CE certified, KFDA approved;

 

• US patent for apatite porosity (US703 7867-1); 
• use of apatite identical to 
Bongros®(synthetic bone) FDA approved (USA);
•   more than 20 years of research into apatite-based technologies; 
• 20 apatite patents
in Korea.
•   Key characteristics of the Facetem S filler

 

The main feature of the Facetem S – its lattice-porous structure. Unlike dermal fillers with a sandy structure, the drug provides more pronounced volume, strength, stability and a prolonged effect, which is achieved due to the slow, controlled degradation of HAC. 

Gel carrier weighing over 700 000 Daltons provides pronounced viscosity and elasticity of the Facetem S filler. 

High elasticity

Facetem S provides maximum lifting effect and volumization with minimum volume.

  The high viscosity

of Facetem S allows the drug to effectively withstand force, maintain its position and not diffuse into surrounding tissues.

  Thanks to the combination of these indicators, excellent rheological properties

of the drug are achieved: the filler is easily injected and takes the required shape, but at the same time it is securely fixed at the injection site

and does not migrate.  Mechanism of action and capabilities of the Facetem S filler 

The action of the filler based on calcium hydroxyaratite Facetem S occurs in 3 stages:  

Step 1. Quick correction of an aesthetic defect.

 

Immediately after administration, the carrier gel in the formulation replenishes volume and/or 

smoothes wrinkles.

Read also:

Case studies of the Full Face technique for age-related changes in patients with different types of aging

   

Step 2.  Stimulation of neocollagenogenesis. After 2-3 months, macrophages gradually absorb the gel, calcium microspheres remain, which form the "framework" and stimulate the production of new collagen by fibroblasts. Degree 

absorption of the transport medium is equal to the degree of connective tissue formation, which creates the constancy of the implanted material, which ultimately consists of hydroxyapatite granules of varying degrees of resorption and cell mass (connective tissue).

   

Photos before and after injection correction with Facetem S

Step 3. Lifting and contour restoration.

A strong network of collagen fibers formed in the dermis forms a new dermal matrix. This new fabric, combined with calcium hydroxyapatite particles, provides long-term structural support and promotes longer duration of effect. 

Thanks to this mechanism, the effect of the drug lasts up to 12-15 months or more.

Improve skin quality  occurs at 4 main levels: 

Fibroblasts.

Activation of cell proliferation   After the introduction of HAC, a higher degree is observed 

proliferation in the skin compared with the introduction of cross-linked HA.

Collagen. Increased collagen production

After a single injection of Facetem S for 9 months, a more pronounced tightening of the network of new type I collagen is observed compared to the effect after administration of HA. A dense collagen network strengthens the dermis, providing long-term structural support to the dermal microenvironment.

Elastine. Increased elastin synthesis

Injection of Facetem S markedly increases the level of elastin in the skin within 9 months compared to HA injections.

Skin thickness. Thickening of the skin

Three months after Facetem injection, skin thickness increases by more than 50% compared to baseline.

You may also be interested in:

Calcium hydroxyapatite injections: preparation, combination of procedures and optimization of results

Elimination of defects associated with age-related bone resorption, such as:

 

in the upper third of the face:

raising the inner part (head) of the eyebrow;
•   in the middle third of the face
: reduction of the projection of the upper jaw and visual displacement
•   posterior to the middle zone of the face, even in persons with preserved teeth, a decrease in the pear-shaped, maxillary and glabellar angles; deepening of the nasolabial folds and adjacent upper lip; contraction of the columella, drooping of the tip of the nose and lengthening of the nose as a whole;  in the lower third of the face
: resorption of the lower jaw.
•  

Before and after face correction with Facetem S

Correction of bone tissue allows you to create a more harmonious volumetric facial rejuvenation. 

Facetem S does not alter tissue phenotype. 

The cell pool in the implant exactly matches the composition of the tissue into which it was inserted. If the implant is inserted under the periosteum, it

  Osteoblasts penetrate and the process of bone formation begins. With intradermal injections, the gaps are filled with fibroblasts.  Indications, Benefits and Reviews of Facetem S

 

Calcium hydroxyapatite filler Facetem S is indicated for

: 

bone replacement;

 

• restoration of volumes in the area of ​​cheekbones, cheeks, temples; 
• full face lift; 
• non-surgical rhinoplasty – nasal bridge correction,
correction of the oval of the face and chin (non-surgical lifting);
•  
• correction of deep nasolabial folds and marionette lines; 
• correction of lipodystrophic changes in the face; 
• skin quality improvement; 
• replenishment of the volume of age-related hands.
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Before and after correction with Facetem S

Key Benefits of Facetem S:

 

tight biological fixation, that is, it is not prone to displacement and extrusion (which sometimes happens with other implants);

 
• 
  a high degree of compliance of the material allows, during its injection, to create the necessary shape by modifying the volume (similar to modeling with plasticine);
 
• 
  HAC ​​is a biocompatible material, not subject to resorption, because supports fibrovascular 
ingrown, which contributes to stable long-term results (12-15 months or more);
•  
  does not cause rejection reactions and long-term adverse reactions (inflammatory, allergic reactions, granuloma formation, does not have a mutagenic effect, does not affect the course of pregnancy and fetal development). 
• Thus, Facetem S calcium hydroxyapatite filler from
official distributor

TOTISPHARMA GROUP – reliable and high-quality drug with unique properties that provides a predictable and long-term result of injectable face correction – what a modern cosmetologist and his patients need.  More interesting videos on our

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