Физиологические и патологические изменения кожи во время беременности

Pregnancy is accompanied by a change in hormonal levels, which is manifested by physiological skin features. However, during pregnancy, dermatological problems and exacerbation of pre-existing skin conditions may occur.

In their treatment, it should be noted that some drugs are contraindicated during pregnancy. It should also be borne in mind that skin manifestations can be a symptom of a serious pathology that requires immediate diagnosis and the appointment of an acceptable treatment strategy for pregnant women.

For example, if a pregnant woman is itchy, ALT and bile acid levels should be checked to rule out hepatic cholestasis of pregnancy. Read about this and other pathologies that lead to skin changes in pregnant women, as well as the tactics of their treatment in this article on the website estet-portal.com.

Physiological changes in the skin during pregnancy

Under the influence of hormonal levels during pregnancy, a woman's skin undergoes physiological changes:

1.    Physiological itching (pruritus gravidarum).
Occurs during the 1st or 2nd trimester of pregnancy. Most often of moderate intensity, diffuse nature, mainly on the trunk. Probably related to dry skin.

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2.    For most women, skin becomes less oily and may be dry.Moisturizing ointments and skin oils relieve subjective symptoms.

3.    Increased perspiration.

4.    Stretches (striae gravidarum).

Stretch marks usually appear in the abdomen, buttocks, chest and mammary glands.

5.    Hyperpigmentation.

Linear hyperpigmentation in the midline of the abdomen (linea nigra), nipples and genital area is a physiological phenomenon.

6.    Changes in vascular architectonics.

Telangiectasias, small hemangiomas, edema of the lower extremities due to impaired venous outflow, occurrence of varicose veins of the lower extremities, constant erythema on the palms.

7.    Hair loss (telogen effluvium).

About 3 months after childbirth, increased hair loss often occurs.

8.    Nail damage.

The appearance of dark longitudinal lines on the nail plate, delamination of the nail is typical.
The most common pathological skin changes during pregnancy

1.    Atopic eczema.

Skin changes are typical for the clinical picture of atopic eczema, usually in history, the diagnosis of atopic dermatitis precedes pregnancy.


Atopic eczema is characterized by exudative and lichenoid eruptions, elevated serum IgE levels, and hypersensitivity to irritants. It has a clear seasonal dependence.

2.    Chloasma and melasma.
Melasma – This is a benign hyperpigmentation of the skin due to increased production of melanin in the form of yellow-brown spots of a non-inflammatory nature. It usually appears on the face and around the eyes. May be prevented with sun protection during pregnancy.


What is the danger of obesity for the skin 3.    Acne.

May worsen or occur for the first time during pregnancy. In this case, the drugs of the first line are benzoyl peroxide and ointments with azelaic acid. For topical dot application to inflamed elements, an emulsion or solution of clindamycin can be used. Topical vitamin A preparations or oral tetracycline are not recommended for use during pregnancy.


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4.    Perioral dermatitis.
Appearance of erythematous papules around the mouth.


5.    Eczema in the genital area.

Eczema in the intimate areas, as a rule, leads to maceration and leucorrhea.


More rare skin problems in pregnancy

1.    Erythema nodosum.

It is a variant of allergic vasculitis, characterized by the appearance of bluish-red nodules along the vessels on both legs. The surface of the skin in the places of formations slightly swells, becomes reddish and smooth. Possible hyperthermia.

2.    Psoriasis.

May appear for the first time or worsen during pregnancy. Topical use of medium to high potency glucocorticoids may be acceptable intermittently, for example for 2-3 weeks. Keratolytic ointments (containing urea) can be used to soften and remove thick scales. Moisturizing ointments usually reduce the need for glucocorticoid ointments and reduce the duration of an exacerbation.

3.    Seborrheic eczema.

Skin problems associated with this pathology include erythematous scaly patches on the eyebrows, nasolabial folds, face, scalp, and ears.

4.    Herpes simplex.

Accompanied by a typical clinical picture.

5.    Lupus erythematosus.

May occur for the first time or worsen during pregnancy. In the systemic form of the disease, the patient has general symptoms, in forms limited to the skin there is a scaly, patchy eczema, aggravated by sunlight, usually localized on the face and upper trunk.

6.    Pregnancy eczemaThe main symptom of pregnancy eczema is an itchy rash. Usually there are no general symptoms, but itching disturbs sleep and therefore causes chronic sleep deprivation and fatigue.

7.    Atopic dermatitis

The most common form of pregnancy-induced eczema. Clinically resembles atopic eczema, with onset early in pregnancy (usually 1st or 2nd trimester).

8.    Bullous Gestational PemphigoidA rare autoimmune skin disease that usually begins in the 2nd or 3rd trimester. Urticarial papules are noted, sometimes grouped into plaques, against the background of which there are vesicles of different sizes and blisters with a tense tire from 0.2 cm to 1.5 cm in diameter.

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Preferential localization on the trunk and proximal limbs; tend to generalize. The diagnosis of gestational pemphigoid is based on positive immunofluorescence of skin biopsies and positive serum antibodies. Often recurs in subsequent pregnancies. Systemic glucocorticoid therapy may cause complications during pregnancy (hypertension, diabetes).

My default image9.    Intrahepatic cholestasis of pregnancy (hepatosis)

Hepatological cholestasis is accompanied by itching, usually most intense on the palms, soles of the feet and abdomen. Occurs after the 30th week of pregnancy. The primary therapy for hepatic cholestasis of pregnancy is ursodeoxycholic acid, which usually normalizes bile acid levels. Antihistamines are used for symptomatic treatment.

The mother should be admitted to the maternity hospital for observation because hepatic cholestasis of pregnancy is associated with a risk of preterm delivery and an extremely low (<1%) risk of fetal death.

10.    Pyogenic granulomaA rapidly growing, erythematous tumor that bleeds easily. It is a lobular capillary hemangioma. It is usually found on the distal extremities. The problem worries every 20th pregnant woman. Etiological factor – bacterial and traumatic. A biopsy is needed to confirm the diagnosis. Recommended methods for removing granuloma – tangential excision and electrodesiccation.

Principles and prognosis of treatment of skin problems in pregnant women
To make a correct diagnosis and select a rational therapy, it is necessary to carefully examine a pregnant woman with skin problems. Determine if the problem is acute or chronic? Were these changes before pregnancy? Does the patient have any congenital feature such as atopic eczema? Does the patient have systemic symptoms related to the skin problem, such as fever and malaise?


Examine all skin for additional manifestations. Give preference to non-pharmacological methods of treatment. The safest drugs are antihistamines and topical application of ointments containing antibiotics and glucocorticoids in acceptable concentrations. It should be borne in mind that chronic diseases often worsen during pregnancy, but taking previously effective drugs can be dangerous for the fetus.

Read more about acceptable medicines for use in pregnancy in the article on our website in the Gynecology section: Evidence-Based Acceptable Pharmacotherapy for Expectant Mothers.

According to the Evidence-Based Medicine Guidelines

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