The level of glycation is today considered to be the determining factor of a person's biological age. This process, which takes place in all structures of the body without exception, has the most noticeable effect on the skin, accelerating its aging, the appearance of wrinkles, pigmentation disorders, and a decrease in tone.
It is impossible to completely stop glycation, however, with the help of complex anti-age measures and modern drugs based on active ingredients that prevent this process, you can protect the skin and delay the appearance of signs of aging.
The essence of the glycation process and its negative consequences for the body
Glication – it is a non-enzymatic process in which sugar molecules react with proteins in the body, causing the proteins to cross-link and lose their functionality.
Follow us on Facebook!
As a result, glycation end products – AGE (Advanced Glycation Endproducts), slowing down metabolic processes and accelerating aging. The pathological effects of AGEs are related to their ability to activate oxidative stress and inflammation by altering the structure and function of proteins.
Glycation affects the entire body. Its consequences include:
• decreased immune defense;
• impaired kidney function;
• neurodegenerative diseases;
• Alzheimer's disease;
• complications of diabetes;
• problems of the cardiovascular system, etc.
Long-lived collagen proteins, as well as other proteins with a long life cycle, are the first to glycate.
UV irradiation accelerates glycation processes. It has been proven that in areas of the skin exposed to UV radiation, the content of advanced glycation end products is higher than in areas protected from the sun. Only young people under the age of 30 took part in the studies, for whom a significant accumulation of AGE is not typical.
How the consequences of the glycation process affect the skin
Three mechanisms are involved in the process of skin aging:
• chronoaging (biological),
• photoaging (related to UV radiation),
• Glycoaging (accumulation of glycation products) Photo- and glycoaging are closely related in the context of oxidative stress.
In the process of glycation, glucose interacts with collagen fibers in the dermis, which leads to disruption of the structure of collagen fibers, loss of their elasticity, accumulation of deformed proteins in the skin, and changes in the structure of the collagen framework as a whole.
Glycation slows down the breakdown of damaged collagen and the synthesis of new. Cross-linked collagen fibers become inaccessible to the collagenase enzyme, which destroys deformed collagen and starts the process of neocollagenesis.
The consequences of glycation in dermatology are a violation of the structure of collagen fibers, inhibition of neocollagenesis, slowing down regeneration, and increasing vascular permeability.
The glycation process up to about 30-35 does not significantly affect the skin. However, when it is launched along with chronoaging, it quickly gains momentum. Under the influence of AGE on tissues:
• skin color worsens;
• UV damage to the skin increases;
• skin becomes wrinkled;
• cell regeneration and skin circulation slow down;
• skin loses moisture and elasticity;
• the skin becomes thinner, dark circles appear under the eyes.
How to slow down glycoaging of the skin: substances that prevent glycation
It is impossible to completely suppress the glycation process, but it can be stopped. The best treatment – it is prevention: dieting, reducing calories and foods high in simple sugars. You can also fight glycation and its consequences with the help of modern preparations, which include substances that can resist this destructive process, such as L-carniosine and silk tree extract.
Wide possibilities of using enzyme preparations
Carnosine
Carnosine is a powerful antioxidant of a wide range of spectrum of action, capable of protecting lipids, proteins and nucleic acids from oxidation. Carnosine delays the aging process and revitalizes fibroblasts. Interacting with glucose, it prevents the binding of macromolecules to each other and the formation of collagen dimers. This is the most powerful prevention of glycation processes in the skin growing after 35 years. It has a unique protective effect against protein degradation and cell aging.
Silk tree extract
Silk tree extract (Albizia Julibrissin) has anti-inflammatory, antioxidant and astringent effects in cosmetics. However, the most sought-after silk tree effect – prevention of aging by influencing the pathological mechanism of glycation.
Silk Tree Extract acts against glycation through two different mechanisms. On the one hand, it prevents this process from starting, on the other hand – neutralizes toxic metabolic products in the skin that trigger the glycation process, and also restores damaged collagen molecules, as well as:
• prevents damage to blood vessels, maintains the integrity of capillary networks;
• reduces the accumulation of "ageing pigment" lipofuscin, consisting of a glycolipoprotein matrix;
• promotes the restoration of melatonin synthesis – the most powerful endogenous free radical scavenger – in fibroblasts subjected to glycosylation.
HISTAN = protection + antiglycation: prevention and correction of problems caused by glycation
The Histan Active series from Histomer, presented on the domestic market by the company
"Intercosmetic Group", is based on a balanced combination of solar filters of the latest generation: a perfect sun protection system – reliable and safe.HISTAN Active formulas are based on a valuable bioavailable ingredient – complex "Antiglycation" based on silk tree (Albizia Julibrissin) and carnosine, which effectively neutralizes the most significant mechanism of skin aging – glycation of collagen.
Complex "Antiglycation" stops the process of collagen glycation and eliminates already existing damage, i.e. "crosslinks" fibers.
• wrinkles;
• cellulite;
• decrease in tone and elasticity.
Histan Smart Drugs provide skin protection, as well as correction of skin imperfections, improvement of the appearance and physical shape of the body, using the energy of sunlight.
Activity of the complex "Antiglycation" enhanced by infrared radiation.
The HISTAN line also includes stem cells of Asian centella CENTELLA STEM CELLS. They start the processes of skin regeneration, make it more elastic and supple. This ingredient demonstrates great effectiveness in tandem with the Anti-glycation complex.
Share:
Add a comment