Psoriasis — It is a non-infectious chronic skin disease. Recently, more attention has been paid not so much to the genetic causes of the development of psoriasis as to the epigenetic mechanisms of the pathogenesis of this disease. It is known that its occurrence is often associated with stress and disorders in the functioning of the nervous system, and therefore, special attention is paid to serotonin in the etiology of psoriasis. This neurotransmitter provides a link between the nervous, immune, endocrine systems and skin. Read more about the influence of the level of serotonin in the body on the course of dermatological diseases, read on estet-portal.com in this article.
Relationship between skin condition and serotonin levels in the body
Serotonin is a kind of link between the neuropsychological and immunological state of the body.
The level of serotonin in the body is one of the determining factors in the occurrence and development of diseases such as psoriasis, hypertension and depression.
The concentration of serotonin in the blood decreases under stress as the neurotransmitter stores are used to restore the balance of the nervous system. In psoriasis, inflammatory mediators activate enzymes that destroy serotonin - a vicious circle is formed. As a result, there is a critical decrease in serotonin, & nbsp; in which the prognosis for patients with psoriasis is significantly worse.
Serotonin levels in the body:
• pathophysiology of fluctuations in serotonin levels in the body;
• level of serotonin in the body: treatment of psoriasis with antidepressants;
• Ways to increase the level of serotonin in the body.
Pathophysiology of fluctuations in serotonin levels in the body
It has been established that when serotonin receptors are activated, such a pro-inflammatory mediator as tumor necrosis factor is suppressed. This suggests that when using drugs that enhance serotonin activity — it is possible to achieve a stable regression of the clinical picture of psoriasis. Tryptophan — the amino acid, whose metabolites are serotonin and melatonin, also has a direct effect on the skin. It regulates the differentiation and proliferation of epidermal cells, metabolism in tissues and internal organs.
Serotonin levels in the body: treatment of psoriasis with antidepressants
Given the close relationship between the development of psoriasis and the negative impact of stress on the nervous system, there are numerous data on the effective use of antidepressants in the complex therapy of psoriasis. Serotonin is actively involved in the development of psoriatic inflammatory skin changes along with prostaglandins and proteases. Accordingly, by influencing the level of serotonin in psoriasis, with the help of antidepressants, it is possible to influence the course and prognosis of the disease.
Ways to increase the level of serotonin in the body
It was previously thought that serotonin levels could be increased by eating foods high in tryptophan, which is a precursor to serotonin. Unfortunately — this statement turned out to be erroneous.
Constant stress and the presence of bad habits contribute to a decrease in the level of serotonin due to its increased consumption.
Significant increases in serotonin levels can be achieved with regular exercise and light therapy. Sunlight can directly stimulate the production of serotonin by interacting with skin receptors, which is especially important for patients with dermatological diseases.
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