The first manifestations of aging in the form of dryness and flabbiness of the skin, barely noticeable wrinkles, rare telangiectasias and age spots, early senile lentiginous rashes, keratomas lead to a significant deterioration in the quality of life.
In this regard, the problem of aging occupies a significant place in cosmetology, plastic surgery, therapy, pharmacology, psychology and other sciences, which are currently united by the concept of medicine «anti-age» in the struggle for youth.
And there is no drug more studied in this field than hyaluronic acid.
Its molecule is constantly amenable to transformation, additions, but the ability of hyaluronic acid to slow down the aging process does not allow a cosmetologist to imagine his work without it.
Why is hyaluronic acid so important, what biochemical reactions does it take part in, and how to make its molecule work hard "for itself", read the article on estet-portal.com
- Biochemical significance of the hyaluronic acid molecule
- The problem of topical application of products based on hyaluronic acid
- Mechanisms for maintaining the level of hyaluronic acid in the layers of cozhi
Biochemical significance of the hyaluronic acid molecule
Indeed, it is hyaluronic acid that determines the structure and functionality of the skin, since it forms the dermal matrix, ensures the interaction of matrix and cellular structures, takes part in the processes of regeneration, detoxification, and maintenance of skin turgor.
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In the composition of proteoglycans, hyaluronic acid is involved in the binding of growth factors and cytokines, and can affect the proliferation, differentiation and morphogenesis of the skin.
In addition, the outstanding function of hyaluronic acid is the hydration of the dermis.
It is known that one of its molecules is capable of holding a number of water molecules 1000 times heavier than its own (the so-called molecular sponge effect).
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Aqueous environment, formed by hyaluronic acid, provides the transport function of various nutrients, respiratory function through the provision of mechanisms for the transfer of oxygen molecules, as well as immune − due to the delivery of immunocompetent cells to different areas of the skin.
Recognizing that dermal fillers perform the function of replenishing lost volumes, company TEOXANE has developed products that are aimed at replenishing hyaluronic acid for the metabolic needs of skin cells .
There are two ways to use drugs to increase the pool of hyaluronic acid:
- topical remedies;
- superficial injections.
The second method allows much faster and more filling of the intercellular space with hyaluronic acid, but trauma to the skin leads to the migration of fibroblasts and the synthesis of even a small amount of inflammatory mediators.
As a result, the amount and activity of the hyaluronidase enzyme, which is also an inflammatory mediator, increases.
Its indicators are diagnostic for chronic rheumatological diseases – lesions of the connective tissue of the ligamentous apparatus of the joints, where the inflammatory process is induced by the immune system.
Therefore, along with a large amount of injected hyaluronic acid, its rapid excretion is observed not due to the use of cells, but due to the enzymatic hydrolysis of hyaluronidasesoh.
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Problems of topical application of hyaluronic acid
The problem of topical application of products based on hyaluronic acid is its transport into the layers of the skin.
Despite its high hydrophilicity, the hyaluronic acid molecule weakly overcomes the hydro-lipid barrier of the skin.
Therefore, in the serum of TEOXANE − RHA® Serum, hyaluronic acid is closed in an amino acid complex, which ensures rapid transport of substances.
This mechanism is quite physiological. In the membrane of each cell there are some kind of protein channels-conductors – transmembrane proteins that provide facilitated transport for components that cannot pass the lipid bilayer of the membranena.
Mechanisms for maintaining the level of hyaluronic acid in the layers of the skin
Hyaluronic acid is synthesized by fibroblasts and mast cells, as well as keratinocytes.
At a young age, they produce a significant amount of hyaluronic acid molecules, therefore, in childhood and adolescence, the dermis, saturated with water, ensures the maintenance of skin turgor and prevents the formation of wrinkles.
With age (after about 25 years), the amount of hyaluronic acid that is synthesized in the skin gradually decreases, sulfonated glycosaminoglycans begin to prevail, which leads to dryness and flabbiness of the skin, loss of its healthy color, and the appearance of wrinkles.
RHA® Serum Serum contains not only hyaluronic acid, which maintains and preserves tissue hydration, but also cross-linked – to form a surface protective film.
This technology ensures the formation of a surface film, preventing transmembrane moisture loss, which allows you to constantly maintain tissue turgor, as well as protect the skin from external triggers:
- solar radiation;
- too "dry" indoor air;
- wind;
- low/high temperature.
TEOXANE Serum − RHA® Serum helps improve overall skin quality and is suitable for all skin types.
The serum formula helps maintain skin hydration, having a cumulative effect, and is also aimed at reactivating the natural mechanisms of skin regeneration, strengthening the dermis and maintaining the physiological protective functions of the skin.
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