For more than 15 years, biorevitalization has been one of the most popular and effective cosmetic procedures. This is a method of prevention and correction of aesthetic imperfections of the skin by saturating its deep layers with hyaluronic acid. In addition to it, the compositions of biorevitalizants contain auxiliary components: vitamins, amino acids, trace elements, antioxidants. As a result, a complex effect of the ingredients on the cells is carried out, in addition, they enhance the action of each other, showing synergy. According to estet-portal.com, an integrated approach to the correction of age-related changes allows you to achieve the best results.
Features of the "golden trio" biorevitalizants for an integrated approach to slowing down aging
Mesopharm (Mezopharm) represents the "golden trio" biorevitalizants of a new generation for an integrated approach to the correction of involutional changes – NucleoSpire system. Numerous practical developments and independent clinical trials testify to the successful use of NucleoSpire system preparations both in anti-age programs and in solving specific aesthetic skin problems (correction of age spots, acne, etc.).
NucleoSpire System – it is a trio of medical products that complement and reinforce each other, realizing the concept of a triple approach.
Innovative Mesopharm biorevitalizants act on the deep layers of the skin and stimulate the process of cell renewal. A visible result is achieved after the first course of procedures. The unique system of biorevitalization and skin repair NucleoSpire:
• starts the mechanism of synthesis of its own HA and activates metabolic processes in the skin,
• stimulates the synthesis of collagen fibers and elastin,
• increases the hydrophilic potential of the skin,
• eliminates flabbiness and sagging.
The combination of DNA and RNA in the NucleoSpire DNA-RNA complex provides a pronounced biorevitalizing and immunoprotective effect due to the renewal of the cell pool and the repair of existing structural damage in the DNA of the cell.
The result of biorevitalization is noticeable after one or two sessions and lasts for 4-6 months. Depending on the frequency of the courses, the effect may persist for a longer time and be cumulative.
Characteristics of drugs used in the integrated approach to biorevitalization
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Drug and characteristics |
Indications for use |
Course and composition |
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NucleoSpire Revitalizing complex A New generation biorevitalizant. Its exclusive formula, combining optimal concentrations of hyaluronic acid and revitalizing ingredients, naturally gives a fresh and radiant look to the skin, corrects hyperpigmentation, and also increases the antioxidant protection of the skin |
Biorevitalization; correction of hyperpigmentations; rosacea; recovery after exposure to aggressive factors (UVR, peels, etc.); prevention of aging; improvement of skin color in smokers
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Course of procedures: 2-4 sessions with an interval of 14 days. Composition: HA concentration -18 mg/ml (1.8%); molecular weight of HA – 1800 kDa; vitamins – C, B5; thioctic acid; coenzyme Q10; buffer system |
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NucleoSpire DNA-RNA Reparant with a pronounced rejuvenating effect. Contains a complex of nucleotides. The drug helps to restore the activity of the DNA of the cell and, as a result, normalizes the cycle of cellular reproduction. Thanks to the action of the complex of nucleotides on the skin, metabolic processes are accelerated, the protective functions of the skin are enhanced to neutralize the negative effects of free radicals |
Skin revitalization, especially delicate areas with thin skin (periorbital area, neck, hands); preparatory stage before aggressive influences; skin rehabilitation; photo- and chronoaging therapy; correction of hyperpigmentations; strengthening of barrier properties and restoration of local immunity; moisturizing the skin, including on the lips; correction of post-acne scars
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Course of procedures: 3-6 sessions with an interval of 14 days. Composition: sodium deoxyribonucleotide 20.0 mg/ml (2.0%); DNA fragments of salmon milt with m.m. less than 450 kDa; buffer system |
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NucleoSpire Hydro Line Extra Biorevitalizant enriched with HA. Contains a balanced complex of vitamins, amino acids and a key antioxidant of our body – glutathione. The drug is designed to restore cellular metabolism and improve tissue trophism, restores hydroreserve, stimulates the synthesis of collagen fibers, provides a lasting lifting effect, eliminating flabbiness and sagging of the skin |
Biorestructuring; wrinkle depth reduction and pronounced skin lifting; increase in elasticity, turgor and skin tone; prevention of aging; recovery after exposure to aggressive factors (UVR, peels, etc.) |
Course of procedures: 4 sessions with an interval of 14 days. Composition: HA concentration -18 mg/ml (1.8%); molecular weight of HA – 1800 kDa; 8 B vitamins; complex of 21 amino acids; a complex of 8 trace elements; glutathione; buffer system
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Features of the application of the "golden trio" preparations for biorevitalization
Injection techniques
Recommended Techniques – micropapular (the size of papules should not exceed 2 mm).
Recommended drug distribution:
• 0.4-0.6 ml – on the neckline;
• 0.4-0.6 – on the neck;
• 1.0 ml – on the skin of the face, on the skin of the hands.
Needle – 30G or 32G.
Packaging – pre-filled syringe of 1.3 or 2.0 ml.
Injection areas – face, neck, décolleté, hands, forearms, inner thigh, as well as any area of involutionally changed skin.
Depth of insertion – medium or medium-deep dermis.
Procedure protocols
One-drug monotherapy: 4 treatments spaced 10-14 days apart (2-3 intensive courses per year, depending on skin condition).
Combination therapy: 4-6 procedures with an interval of 10-14 days, alternating the use of drugs according to the schemes: Complex A – DNA-RNA – HL Extra – DNA-RNA.
The successive use of three biorevitalizants in a course of alternating preparations of enriched hyaluronic acid and DNA-RNA complexes provides a number of advantages for both the patient and the specialist, increasing satisfaction from the biorevitalization procedure as a whole.
Correction of hyperpigmentation: 5 procedures with an interval of 10-14 days, alternating the use of drugs according to the schemes: Complex A – DNA-RNA – Complex A – DNA-RNA – HL extra. To restore skin color, strengthen blood vessels, increase skin turgor, reduce the depth of wrinkles, improve the immune status of the skin.
Anti-age therapy: 7 procedures with an interval of 10-14 days, alternating the use of drugs according to the schemes: Complex A – DNA-RNA – HL Extra – DNA-RNA – Complex A – DNA-RNA – HL Extra.
It is used in case of deep age-related changes and/or noticeable damage to the skin as a result of exposure to environmental factors – UV, low temperature, professional factors and more.
The results of clinical studies of an integrated approach to biorevitalization
Study of the anti-aging and whitening properties of medical products of the NucleoSpire system in the correction of involutional changes in the skin of the face, neck and hands was carried out at the SkinLab Laboratory at the Clinic for Preventive Medicine «Vallex M».
The study involved 12 women aged 40-65 years. Course: combination therapy – 7 injections with an interval of 14 days. Study duration: 4 months. Studies have shown an increase in skin hydration and elasticity after the course.
Therapy with NucleoSpire products has a positive effect on the viscoelastic properties of the skin of the face and neck, provides a lifting effect, smoothes wrinkles, improves the condition of the skin as a whole, including the reduction of pigmentation.
NucleoSpire line drugs from Mezopharm passed quality control and are registered as medicines in Ukraine: Registration certificate No. 14740/2015. Certification of production sites was carried out according to the GMP 9 standard in accordance with GOST R 52249-2004 "Rules for the production and quality control of medicines".
All production sites have been licensed for the right to manufacture medicines and pharmaceutical products. Our foreign partners – Ingredient manufacturers work within the framework of the ISO 9001:2008 quality management system.
Mesopharm: "We are developing to provide the field of aesthetic medicine and professional cosmetology with high-quality and, most importantly, safe products."
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