Women with silicone breast implants are up to eight times more likely to be diagnosed with one of several chronic autoimmune diseases than women in the general population and are at significantly greater risk of other adverse outcomes, including melanoma and stillbirth &ndash ; these are the results of a study conducted by Christopher J. Coroneus of the Department of Plastic Surgery at the MD Anderson Cancer Center in Houston, Texas.
For more details about the results of the analysis of the data, see our article estet-portal.
- Materials and methods for studying the risk of autoimmune complications
- Risk of autoimmune complications after breast implants
- Whether to be afraid of breast enlargement due to breast implants
Materials and methods for studying the risk of autoimmune complications
Reports were reviewed from 99,993 patients enrolled between 2007 and 2010 in studies conducted by Allergan and Mentor.
The analysis included women aged 22 years and older who received either unilateral or bilateral implants with silicone or saline solutions for primary or revision breast augmentation, and women aged 18 years and older who received implants for the purpose of primary or revision breast reconstruction after cancer resection, trauma, or due to breast hypoplasia.
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Of the entire cohort, 83,317 patients had silicone implants and the rest had saline implants.
Risk of autoimmune complications after breast implants
The analysis showed that in women with silicone breast implants:
• 8 times more likely than in the general population to be diagnosed with Sjögren's syndrome,
• 7 times more likely to have scleroderma,
• almost 6 times more likely to be diagnosed with rheumatoid arthritis,
• 4.5 times the risk of stillbirth,
• 4 times increased risk of melanoma (for each P score <0.001).
No association was observed between silicone implants and suicide, as suggested in previous studies. One case of anaplastic large cell lymphoma has been reported, which was associated in earlier studies with breast implants.
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In terms of surgical complications, silicone implants were associated with an increased risk of capsular contracture compared to saline implants (5.0% vs.
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Mark Clemens and colleagues acknowledge that despite the significantly increased risk of certain medical conditions associated with silicone implants, the absolute rates of these adverse outcomes were low.
FDA also is of the opinion that there is insufficient evidence to support an association between breast implants and rheumatological or connective tissue diseases. They are based on their own review in 2011, writes Ashar in his article.
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Thus, the data presented indicate the possibility of an increased risk of developing systemic and autoimmune diseases after the installation of breast implants, however, the methods by which these data were obtained leave doubts. It is impossible to exclude the influence of other factors on the development of these diseases in patients who underwent mammoplasty. This issue requires a detailed follow-up study with an analysis of long-term consequences.
You may be interested in other articles on our website estet-portal.com in the "Experts" section.
Adapted from Medscape
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