Assessing the efficacy and tolerability of the nutrakos® amino acid supplement

 

The condition of the skin, the main barrier to protection from the external environment, tends to deteriorate due to dermatological problems, environmental conditions and its inherent aging process. Damage to its structure and functioning can be aggravated by smoking, drinking alcohol and constant exposure to the sun (external factors). All of the above leads to the appearance of wrinkles, age spots and thickening of the skin layer. One of the effective strategies to slow down the aging process – healthy nutrition through a balanced diet and sufficient nutritional supplements. With its help, the necessary proportion of macro- and microelements is restored, which maintain the physiological state of skin cells and tissues. In this article, estet-portal. Amino Skin Benefits The purpose of the study of Nutrakos drinking formula with amino acids

• Nutrakos Dietary Supplement Study Design
• Evaluation of the effectiveness of the study drug Nutrakos
• Study results on the efficacy of food
• amino acid supplements
• The benefits of amino acids for the skin  Amino acids – unique components for nourishing the skin, the only necessary substances to stimulate the synthesis of any protein, because they are the main components of the extracellular matrix. The type and amount of amino acids for protein synthesis

can be predicted based on the quality and quantity of amino acids in each protein. But with collagen and elastin, everything is not so simple –

certain amino acids must be ingested in the form of precursors

to activate fibroblast triggering of synthesis. Therefore, the synthesis of collagen and elastin can be effectively maintained only with the constant availability and correct proportion of these amino acids.

When taken orally, amino acids enter the small intestine, from where they are absorbed into the bloodstream. A network of blood vessels carries free amino acids throughout the body, including the dermis, where they can remain for up to 14 days. In the dermis, free amino acids become components for the formation of collagen and elastin fibers.

For the pilot study,

Nutrakos drinkable formula from Professional Dietetics

with six amino acids in a certain proportion

, proven methodologically and clinically, which guarantees an adequate and balanced response to gene expression and the production of collagen and elastin by fibroblasts

. Research Purpose of Nutrakos Drinking Formula with Amino Acids  The main goal of the study – evaluate the effect of Nutrakos® amino acid supplementation; on the hydration and elasticity of skin areas exposed and not exposed to sunlight (volar and dorsal surface of the forearm) using non-invasive instrumental measurements.  

 

The study was conducted on 12 female volunteers aged 39 to 62 years (mean age 50 years) whose skin showed signs of photoaging and was type II or III according to the Fitzpatrick classification. All gave informed consent to participate and took the study drug for one month.

NUTRAKOS drinking formula – nutritional supplement with a proprietary blend of amino acids that stimulate collagen and elastin production

Dermal bioregeneration: advantages and possibilities of Sunekos

The clinical study was approved by an independent ethics committee in 2018.

Nutrakos Dietary Supplement Study Design

Open-label pilot clinical study involving

continuous dietary supplementation for 1 month at a dosage of two sachets per day: the first – before breakfast, and the second – before dinner. The study drug was taken as is or dissolved in water or a cold drink of your choice. There were three visits during the study: original;

interim (after two weeks of taking the drug); final (after a month of admission).

Inclusion criteria required healthy adult volunteers to maintain their dietary, physical activity, make-up and skincare habits, and avoid high UV exposure (no tanning beds or sunbathing) for the duration of the study. Smokers, those who use alcohol or drugs, and pregnant women were not allowed to

participation.

Evaluation of the effectiveness of the study drug Nutrakos 

• The effectiveness of the study drug was determined using
instrumental assessments of hydration
• (superficial and deep)
and skin elasticity
• (also superficial and deep). All evaluations were performed at baseline (T0), two weeks (T2H) and one month (T1M) after dosing on one side of the right or left forearm (volar and dorsal) according to a randomized list of participants compiled by the investigator prior to enrollment.

HYDRATION AFTER 30 DAYS (**):

On the surface (0.5 mm)

Deep (1.5 mm)

(**) volar surface

 

Fig. 1. Skin hydration after 30 days on the volar surface of the forearm

 

SKIN ELASTICITY AFTER 30 DAYS (*):

On the surface (1 mm)

Deep (3 mm)

(*) dorsal surface

Fig. 1.

Skin hydration after 30 days on the dorsal surface of the forearm

Results of a study on the effectiveness of a dietary supplement with amino acids 

During the entire period of the study, not a single patient withdrew from it; there were no other significant events that could affect the test results. Statistical analysis was performed on 12 included patients who completed the study according to the protocol.

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The activity of the test drug at each moment of the study is expressed in absolute values ​​compared to the baseline (T0). Data processing was performed using the non-parametric test (Fridman test), and the hypothesis of a normal distribution was rejected using the Shapiro-Wilk test

(threshold of 5%) or

parametric test

(ANOVA for repeated events). When the hypothesis of a normal distribution was confirmed, in the case of a statistically significant result, both types of testing were carried out according to the

Holm-Sidak correction

.

  Performance evaluation

Skin hydration Skin moisture measured in deep layers using MoistureMeterD. The viscoelasticity of the skin on the volar surface of the forearm improved significantly one month after the start of the drug.

These results emphasized the effectiveness of the reception for the volar surface of the forearm, starting from T2H, which was maintained until the end of the study, T1M. A clinically/statistically significant increase in skin hydration was found at depths of 0.5 mm and 1.5 mm (Fig. 1). On the dorsal surface of the forearm, where photoaging is more noticeable, an improvement in deep hydration was recorded at both the level of 0.5 mm (starting at T2H) and at the level of 1.5 mm (condition at T1M) deep into the skin, which is a sign of a curious, although so far and negligible impact in the dermis at medium depth.

Torsiometry (skin elasticity)

Measurements of superficial and deep skin elasticity were taken on the forearm (volar and dorsal surface).

The viscoelasticity of the skin has improved significantly

on the volar surface, starting from one month after the start of the drug (on the surface and in the deep layers of the skin). A statistically

significant improvement in elasticity was noted after 30 days

on the dorsal surface, which is more prone to damage due to photoaging and elastosis (Figure 2). These parameters are associated with improved skin tone/density.

Other torsiometric data did not reach statistical significance (perhaps due to the small sample size), but there was a curious trend towards improvement in skin elasticity.

 

Volunteer performance evaluation

At the end of the study (T1M), each patient completed a questionnaire on the efficacy and tolerability of the treatment. Considering all the answers "medium", "noticeable" and «very noticeable», there is a clear

positive feedback from the participants about the drug in terms of its effect on the elasticity, hydration and smoothness of the skin.  

No adverse events/reactions occurred during the study. The investigator rated the tolerability of the test drug as good/excellent in 100% of the patients.

Conclusions

Taking into account the accepted scheme of the experiment, this pilot study confirmed the increase in hydration and elasticity of the dermis as a result of taking a dietary supplement with amino acids

Nutrakos (

official distributor – company DMK Ukraine

)

. This drug allows you to restore the biological functions of the skin and cope with metabolic stress caused by exposure to UV radiation, smoking and environmental pollution, which contribute to skin aging. One particularly interesting result of the – statistically significant

improvements in hydration and elasticity

were found as early as two weeks after starting the drug. It is important to note that several other hydrolyzed collagen supplements offered for skin aging have been shown to be effective after at least four weeks of supplementation. You may also be interested in: Stimulation of your own collagen and elastin production: Sunekos injections for skin bioregeneration This result may be due to the actual discovery of a standardized cluster of amino acids best suited to stimulate protein synthesis targeting extracellular matrix proteins.

It will be interesting to confirm these preliminary results with a clinical trial in a larger sample of patients. Final tolerability of the drug was assessed as good/excellent; no adverse reactions associated with its use were observed during the study .

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