Stop, moment, you are fine or correction of age-related changes

Youth – a very temporary privilege, so millions of people around the world are working to extend this state for as long as possible. Healthy and beautiful skin depends on a number of factors: from the right lifestyle, good nutrition and sleep, to well-chosen procedures in the cosmetologist's office and home care.

It is a comprehensive approach to anti-age correction that guarantees the most noticeable and, not least, lasting results.

Dermatovenereologist, trichologist, cosmetologist, assistant of the department of medical faculty of KhNU named after M.V. V.N. Karazina, member of UADV, UHRS Trainer of the "Academy of Scientific Beauty" Kharkiv – Elena Salenkova.

Skin aging: why age-related changes occur

Why does skin age? There is no single answer to this question. Aging of the body and, in particular, of the skin is a complex multifactorial biological process that can be divided into chronobiological aging and photoaging (the leading factor is UV irradiation).

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Modern views on the etiopathogenesis of skin chronoaging come down to various theories, each of which offers its own scenario: Maylord's theory of glycation, Harman's free radical theory, telomeric theory of aging, and others.

According to the theory of the American scientist Maylord, skin aging is caused by non-enzymatic reactions between monosaccharides and proteins, which leads to damage, first of all, of collagen and hyaluronic acid in the dermis.

Harman's free radical theory links damage to dermal structures with oxidative stress and aggressive exposure to reactive oxygen species. The telomere theory explains aging by a decrease in the replicative ability of fibroblasts due to the shortening of the terminal sections of chromosomes – telomeres.

The mechanisms that describe these theories are most likely not mutually exclusive, and are of interest to cosmetologists, since they make assumptions about the links in the etiopathogenesis of chronoaging.

From a clinical point of view, chronoaging is characterized by atrophy, thinning, desolation of the microvasculature, a decrease in the elastic properties of the skin, the presence of superficial wrinkles and pallor due to inhibition of melanogenesis.

Photoaging, on the other hand, is directly correlated with the total dose of ultraviolet radiation and the skin phototype. Various manifestations of skin photodamage may appear earlier than signs of chronoaging and are characterized by hyperkeratosis, uneven pigmentation, the presence of telangiectasias and deep wrinkles with predominant localization on open areas of the body (face, neck, décolleté, hands).

Despite the different causes and manifestations, both types of aging are united by common processes in the dermal space: a decrease in collagen types I and III, which, in turn, leads to the appearance of wrinkles and gravitational ptosis of the skin. At the same time, pronounced elastosis will be a specific sign for skin photoaging, while the histological picture is a decrease and degradation of collagen against the background of an increase in the deposition of elastoid masses in the upper and middle layers of the dermis.     

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Dermal fibroblasts: the role of cells in maintaining youth

Fibroblasts are responsible for maintaining the homeostasis of the dermal space. It is the number, functional activity, proliferative potential of these cells that largely determine the micro- and macrostructure of the skin.

Human dermal fibroblasts synthesize:

1.    Collagens types I, III, IV, V, VI, VII;

2.    Glycoproteins: fibronectin, fibrillin, thrombospondin, laminin, tenascin;

3.    Glycosaminoglycans: hyaluronic acid, heparan sulfate, chondroitin sulfate;

4.    Proteoglycans: versican, decorin;

5.    Matrix-modifying proteins: matrix metalloproteinases, tissue proteinase inhibitor;

6.    Cytokines: IL-1, 6, 10, TNFα

7.    Growth Factors: TGFß, CSF-1, GM-CSF, PDGF, bFGF, IGF-1,2, NGF, KGF, HGF, SCF, VEGF;

8.    Chemokines: IL-8, MCP-1, GRO-1, MIP-1,2, RANTES, ENA-78;

9.    Inflammatory mediators: phospholipase-A2, prostacyclin, PGE2, HETE, PAF, NO.

Thus, the main functions of fibroblasts include organization and renewal of the intercellular space, regulation of the inflammation process, angiogenesis, regeneration and regulation of epidermal differentiation.

For a number of reasons (genetic factors, the influence of oxidative stress, etc.), with age, there is a decrease in the proliferative and synthetic activity of fibroblasts, which leads to qualitative and quantitative changes in the intercellular matrix of the dermis.

Remodeling and restructuring of the dermis are the key goals that are set and successfully solved by the preparations of the RRS Hyalift line presented by the company

«Academy of Scientific Beauty».

Combo effect: skin rejuvenation regimen for patients 45+

RRS Hyalift – "elixir of youth"

The abbreviation RRS stands for "Repairs, Refills, Stimulates", which means "Restoration, Filling, Stimulation" in translation. This is how you can briefly describe the main results that a cosmetologist can achieve by working with this line of drugs.

The first violin in the

RRS Hyalift orchestra is played by high molecular weight unstabilized hyaluronic acid. There are 3 products in the line:

1.    Hyalift 35 - 7 mg/ml – 0.7%

2.    Hyalift 75 - 15 mg/ml – 1.5%    

3.    Hyalift 75 Proactive – 15 mg/ml – 1.5% HA + 17 Amino Acids + Resveratrol

Hyaluronic acid, being one of the main components of the extracellular matrix of the dermis, has a pronounced hydro-lifting effect: on the one hand, it creates and maintains a sufficient level of skin moisture, on the other hand – is a stimulator of neocollagenesis. These effects have been demonstrated and confirmed in a number of independent studies. In a study by K. Rock et al. (2010) found the proliferation of fibroblasts in the areas of injection of unstabilized hyaluronic acid.

Thus, RRS Hyalift 35 and RRS Hyalift 75 preparations, being monocomponent, in addition to supporting and moisture-retaining functions, also coordinate the vital activity of skin cells, initiating the synthetic activity of fibroblasts.

Biorevitalization has gone from monocomponent preparations to combined ones, in which the action of hyaluronic acid is supplemented with other components in order to enhance and prolong the effect of the procedure. Of particular note is Hyalift 75 Proactive, presented by

"Academy of Scientific Beauty", which in addition to hyaluronic acid contains 17 amino acids of plant origin and a powerful antioxidant resveratrol.

The rich amino acid series includes:

•    Glutamic Acid

•    Alanine

•    Arginine

•    Aspartic acid (aspartate)

•    Phenylalanine

•    Glycine

•    Histidine

•    Leucine

•    Isoleucine

•    Glutamine

•    Threonine

•    Betaine

•    Proline

•    Serine

•    Taurine

•    Tyrosine

•    Valine

Tissue regeneration, hydration, lifting, nutrition, elimination of the consequences of photodamage, improvement of the metabolic activity of fibroblasts – this is not a complete list of the achievements of the above amino acids.

According to recent studies, resveratrol prevents lipid peroxidation and protein oxidation, its antioxidant activity (95%) exceeds that of vitamin E (65%) and vitamin C (37%), respectively.

In vitro studies have shown that the antioxidant activity of resveratrol was 17 times higher than that of the synthetic coenzyme Q10-idobenone. In addition to its effect on skin metabolism, anti-aging activity, depigmenting properties, resveratrol also has a wide range of antimicrobial activity, which makes it a powerful weapon in the fight against acne.

We can't stop time. One way or another, the processes of chrono- and photoaging will affect each of us. However, it is in our power to delay these manifestations as much as possible or to eliminate existing ones. Our patients have the opportunity to make their choice – stay young, have healthy skin and smile at your reflection in the mirror. And this choice is given to them by RRS Hyalift.    

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