Polyrevitalization against skin aging: what are the advantages of the mesotherapy approach

Skin aging cannot be stopped, but it can be slowed down, and this is the main principle of aesthetic geroprotection. The key signs of age-related changes are a decrease in the quantity and quality of hyaluronic acid in the skin, a slowdown in lipid synthesis in the epidermis, a deterioration in microcirculation and collagen production. To slow the progression of these signs, it is important to introduce substances into the skin that can start cell renewal. According to estet-portal.com, the mesotherapeutic method of administering the NCTF 135 preparation from the Filorga Laboratory (France), which contains bioactive substances and hyaluronic acid, can help in the fight against aging.

Mesotherapy cocktail – key element of skin polyrevitalization

In order for the bioactive substances necessary for the skin to penetrate deep into the skin and start the processes of cell renewal, mesotherapy procedures are used. And to restore the pool of hyaluronic acid and moisturize the skin, biorevitalization is used. The injectable NCTF 135, developed by the FILORGA Laboratory, combines the benefits of both procedures in the fight against age-related skin changes.

NCTF135 is the perfect blend of nourishing and stimulating ingredients with highly purified hyaluronic acid.

The new skin injection procedure with NCTF135 has been called polyrevitalization. During the procedure, controlled trauma to the epidermis and dermis stimulates the activity of fibroblasts, improves tissue trophism, and promotes the synthesis of new collagen. The mesotherapeutic effect triggers a cascade of vascular and cellular reactions that contribute to the firming and hydration of the skin. In addition, the deposited hyaluronic acid, which is part of the preparation, gives a visually quick lifting effect and gives radiance to the skin.

Composition of the mesotherapeutic cocktail for the polyrevitalization procedure

Laboratories Filorga offers three versions of NCTF 135. They are recommended for aesthetic geroprotection, their action is aimed at preventing and slowing down involution processes in the skin.
Each of the NCTF 135 preparations contains unreticulated hyaluronic acid and a cocktail of 54 active ingredients. Among them are 12 vitamins, 23 amino acids, 6 coenzymes, 5 nucleic acids, 6 minerals, 2 antioxidants. for skin polyrevitalization

NameNCTF 135 (0.025 mg/ml)NCTF 135 HA (5 mg/ml)NCTF 135 HA+ (10 mg/ml)Preparations meet the needs of all skin types and have 2 levels of exposure – superficial (at the level of the epidermis) and deep (at the level of the dermis).

Indications	Results
Prevention of skin aging, correction of first wrinkles	Hydration and radiant skin color, improvement of microrelief, correction  small wrinkles
Combating the signs of aging and maintaining skin architectonics	Intense hydration, firming and elasticity of mature skin, wrinkle correction, radiant color
Intensive care for aging skin, skin photoelastosis	High-intensity hydration, accelerated recovery of aging skin density, wrinkle correction, firming, radiant color

According to the French independent research center specializing in cellular and molecular pharmacology, polyrevitalization with NCTF shows the following results:

•    stimulates the proliferation of young fibroblasts, activates cell renewal;

•    stimulates the synthesis of proteins rich in proline (mainly type 1 collagen);

•    helps protect cells from oxidative stress by reducing the production of lipid peroxidation products.

The study showed that NCTF135 has a statistically significant effect on extracellular concentrations of an RNA-specific elastase inhibitor. By stimulating the expression of this gene, NCTF135 prevents the loss of tissue elasticity.

Protocol of polyrevitalization with mesotherapy cocktail

The main course of polyrevitalization procedures consists of 5 sessions, which are carried out in two stages: first, 3 procedures – with an interval of 15 days, then 2 procedures – at intervals of 1 month.

To maintain results, one treatment is prescribed every 3 months. The scheme can be adapted depending on the individual characteristics and needs of the patient.

Injection Technique:

•    multipuncture – the drug is injected with a 30G needle along the course of wrinkles with very superficial intradermal microinjections; small, barely noticeable papules are located at regular intervals at a distance of several millimeters from each other;•    nappazh – the drug is administered with a 30G or 32G needle by intradermal microinjection; papules are located at a distance of about 1 cm from each other, about 0.1 ml of the drug is used for each; the technique is suitable for treating the skin of the neck, décolleté, back of the hands.
The procedure is highly safe and has minimal side effects: according to a multicenter clinical study, slight redness is noted in 12% of cases, swelling – in 7%, and hematomas – at 5%. About 97% of patients were very satisfied with the results obtained, which appear immediately – This is a reduction in the appearance of wrinkles, an improvement in skin tone. In addition, polyrevitalizants from
company FILORGA

have a delayed effect: skin moisture gradually increases, its healthy glow appears.