As we age, the ability of tissues to repair rapidly declines. Due to the deterioration of microcirculation, violations of the structure and function of the elements of the intercellular matrix, visible age-related changes appear on the skin – flabbiness, wrinkles, dryness, dullness, age spots.
Therefore, in aesthetic medicine, a special place is occupied by procedures aimed specifically at skin regeneration, such as plasma therapy. With the Arthrex system from the official distributor of TOTISPHARMA GROUP, which allows the use of autologous plasma without the addition of an anticoagulant, maximum safety and efficiency of the plasma therapy procedure is achieved.
- Composition, action and benefits of autologous plasma
- Forms and application of autologous plasma in cosmetology
- Benefits and Opportunities Arthrex
Composition, action and benefits of autologous plasma
Autologous plasma physiology:
- Endogenous resource;
- Source of vital components of cellular and tissue homeostasis;
- Does not require resource costs and immune initiation of the body to ensure bioavailability;
- Ideally combined with any drugs and implants, providing bio- and hemocompatibility in combined protocols.
Own plasma – one of the most affordable regeneration techniques that works at all stages of regeneration due to its composition:
- Water (about 90%);
- Proteins (albumins, globulins, fibrinogen);
- Non-protein, nitrogen-containing compounds;
- Nitrogen-free organic compounds;
- Mineral substances.
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In addition to the increased concentration of platelets, PRP- and PRF contain a huge amount of autologous proteins that perform a number of important functions: structural, transport, immune, enzymatic. These include:
- Albumins;
- Globulins;
- Fibrinogen, platelet proteins, fibronectin, etc.
Safety and minimizing unwanted reactions – undeniable advantage of using autologous plasma for rejuvenation.
Activation of platelets during plasma processing:
- Leads to a change in the disc-shaped form of platelets to spherical, the formation of their processes and adhesion of platelets to subendothelial structures, in particular collagen;
- Provides the initial aggregation of platelets and the release of a number of substances from them that serve as strong stimulators of fibroblasts.
Fibroblasts are activated during plasma therapy, which:
- Synthesize the main components of the connective tissue – collagen, elastin and HA – own substances of the dermis, which are responsible for the beauty and health of the skin, make it supple, moisturized, elastic, radiant;
- Promote the production of proteoglycans, fibronectin and other elements of the extracellular matrix.
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Collagen
- Makes up to 40% of all body proteins;
- The most important protein in connective tissue, tendons, skin, cartilage;
- The building protein of all living cells, providing strength;
In the process of aging, the number of bonds between the chains gradually increases and the elasticity of the collagen molecule decreases.
Collagen synthesis is carried out in fibroblasts in the presence of the amino acids glycine, alanine, proline, valine and cysteine.
Autoplasma contains all the amino acids that are essential for normal collagen formation and function.
The presence of own enzymes (hyaluronidase, etc.) in autologous plasma ensures the destruction of damaged elastin, collagen and IG, the restoration of balance and the synthesis of new microstructures. The process of destruction-restoration takes place continuously, providing renewal of the extracellular matrix.
Growth factors in autologous plasma:
- Vascular endothelial growth factor (stimulates cell proliferation of the vascular wall and lymphangiogenesis, increases the permeability of the vascular wall, consequently increases the number of capillaries and tissue nutrition);
- Epidermal growth factor (stimulates the proliferation of epithelial cells and fibroblasts);
- Fibroblast growth factor (playing a key role in the processes of proliferation and differentiation of a wide range of cells and tissues);
- Transforming growth factor (stimulation of collagen synthesis);
- Insulin-like growth factor (stimulation of fibroblast proliferation, collagen synthesis and other components of MCM).
Specific plasma proteins, in particular beta-lysine – increase antibacterial activity when plasma is injected into tissues, and also relieves swelling and inflammation in the presence of rashes, scars or post-traumatic changes.
Thus, autologous plasma contains everything necessary for effective skin regeneration at all stages.
Plasma Therapy provides:
- Destruction of damaged elements of the extracellular matrix;
- synthesis of new functional youth proteins collagen and elastin, hyaluronic acid;
- neoangiogenesis and, accordingly, improvement of metabolic processes and tissue nutrition.
Such a complex action ensures constant skin regeneration.
Read also: New in Tissue Regeneration: Synergy of PRP and Stem Cells
Maximum effect will be noticeable in a month and a half after the last treatment. Recommended course: 3–4 plasma therapy procedures with an interval of 14 days. Plasma therapy – all-season treatment without the risk of pigmentation or other side effects.
Forms and application of autologous plasma in cosmetology
Forms of autologous plasma for use in cosmetology.
PPP – platelet-poor plasma (an index of decrease in plasma concentration relative to the concentration in the CK from 20% to 80%). This plasma is ideal for patients with couperosis and rosacea, as PRP can exacerbate these conditions through active angiogenesis caused by high levels of platelet growth factor. PPP contains fewer platelets, but many important proteins that improve all metabolic processes in the skin.
PRP – platelet-rich plasma (index of increase in plasma concentration relative to the concentration in the CC from 200% (with a single centrifugation) to 800% (with a double centrifugation).
As a rule, sodium citrate is used for PRP therapy – universal anticoagulant. It blocks calcium ions and prevents blood clotting. The operating time with such plasma is unlimited.
PRF – fibrin-rich plasma (index of increase in plasma concentration relative to concentration in the CK from 150% to 200%).
Benefits and features of the Arthrex system
The PRF that can be obtained with the Arthrex system does not use an anticoagulant. Therefore, when working with PRF, it is necessary to take into account the physiological clotting time – 15 to 20 minutes
The lack of an anticoagulant makes PRF the most hypoallergenic product and an excellent alternative for patients who experience allergic reactions to any cosmetic procedure.
Arthrex-derived PRF retains important proteins:
- Beta-lysine, which has an antibacterial effect. Therefore, PRF perfectly relieves inflammation and works with acne, for this the product is injected deep under the inflammatory element from a distance of 5-7 mm from it.
- Fibrin, which is involved in all stages of healing; after it, as a rule, there is no reactive inflammation.
- Fibronectin, which is a component of the extracellular matrix and regulates the increase in cell culture adhesion, i.e. participates in increasing skin elasticity
The plasma therapy procedure is very simple (blood sampling – centrifugation – introduction), provides excellent stable results of skin rejuvenation due to regeneration at all stages: platelets stimulate fibroblasts to synthesize HA, collagen and elastin, amino acids provide their effective development. Autologous enzymes metabolize damaged MKM fibers and actively remove them due to increased microcirculation, which is caused by the action of vascular endothelial growth factor.
The use of fibrin-rich plasma reduces the risk of allergic reactions to zero. In addition, PRF goes well with popular cosmetic procedures – biorevitalization, mesotherapy, and therefore the Arthrex system from the official distributor TOTISPHARMA GROUP will be an excellent addition to the arsenal of a modern cosmetologist.
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