Systemic lupus erythematosus occurs in the practice of doctors of all specialties, due to the variety of manifestations of this pathological condition. The reason for this is an autoimmune lesion of almost all organs and systems, which can be clinically masked as & nbsp; other diseases and requires differential diagnosis.
Rarely, people suffering from systemic lupus erythematosus immediately become patients of rheumatologists. That is why doctors of all specialties need to be guided in the development of systemic lupus erythematosus. In more detail about antinuclear antibodies as markers of the presence and the main reason for the development of the clinical picture of systemic lupus erythematosus – read on estet-portal.com in this article.
The role of antinuclear antibodies in the development of systemic lupus erythematosus
It is well known that the pathological production of autoreactive antibodies is the basis for the development of systemic lupus erythematosus, leads to damage to all organs and systems of the human body, and causes an extremely severe course of this disease.
As a result of impaired immunological tolerance in systemic lupus erythematosus, plasma cells synthesize pathologically large amounts of autoreactive immunoglobulins.
The formation of antibodies to native DNA plays the greatest role, to a lesser extent – plasma membrane proteins, organelles and other structural components of the cell. Immunoglobulins, when combined with self-antigens, lead to the formation of circulating immune complexes.
The latter tend to accumulate on the basement membrane of the histological structures of almost all internal organs and skin, which leads to the development of multiple organ failure in systemic lupus erythematosus, namely: damage to the lungs, heart, kidneys, organs of the reticuloendothelial system, skin and other structures .
Systemic lupus erythematosus:
• What is known about antinuclear antibodies in systemic lupus erythematosus;
• Features of antinuclear antibodies in systemic lupus erythematosus.
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What is known about antinuclear antibodies in systemic lupus erythematosus
Antinuclear antibodies are not pathognomonic for systemic lupus erythematosus and may be present in many other rheumatological diseases. The presence of their subtype, IgG-Ab to double-stranded DNA, is almost always the basis for confirming this diagnosis and plays a key role in the development of systemic lupus erythematosus. According to modern concepts, a healthy person can synthesize class M immunoglobulins to single-stranded DNA. They are a component of normal immune defense and do not lead to the development of autoimmune aggression due to low DNA avidity and polyreactivity of such antibodies in general.
Features of antinuclear antibodies in systemic lupus erythematosus
People with systemic lupus erythematosus have anti-DNA immunoglobulins that are different from those that can be identified in normal or other rheumatic diseases.
Antinuclear antibodies are not specific for systemic lupus erythematosus, they can be identified in many other rheumatic diseases and even in healthy people.
The features of antinuclear antibodies characteristic of systemic lupus erythematosus include: Share:
1. High avidity for double-stranded DNA;
2. Affiliation of immunoglobulins to class G;
3. Tendency to form circulating immune complexes with subsequent activation of the complement system. the most important component of all structures of the human body, as well as & nbsp; the formation of circulating immune complexes with their accumulation on the basement membrane of the histological structures of the target organs, leads to a severe course of this disease and requires the immediate appointment of
therapy for systemic lupus erythematosus
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