Adapalene — This is a synthetic drug from the group of retinoids, which is most often used in the complex therapy of acne. Current research indicates that adapalene may have broader indications, such as its use in the treatment of alopecia areata. The appointment of a combination of adapalene and corticosteroids has a better therapeutic effect than the use of hormonal drugs alone. Read more about the treatment of alopecia areata with adapalene on estet-portal.com in this article.
Peculiarities of using adapalene in dermatological diseases
The causes of alopecia areata are not fully understood, but an autoimmune mechanism for damage to the hair follicle is suspected. Also, HLA class II antigens play a special role, which determine the predisposition to the development of this disease.
During the development of alopecia, the number of hair follicles decreases, local immunity cells are involved, which additionally damage the hair follicle.
Treatment of alopecia areata is carried out by influencing two main pathogenetic links: adapalene reduces the migration of immune cells to the follicle zone, and corticosteroids — reduce the activity of the inflammatory process.
Adapalene:
• mechanism of action of adapalene on the affected areas of the skin;
• adapalene and mometasone furoate: treatment regimen for alopecia areata;
• possible side effects of using adapalene.
Mechanism of action of adapalene on the affected areas of the skin
Adapalene acts on the skin by binding the drug to specific epidermal skin cells. As a result, the adhesion strength of epithelial cells decreases, especially in the area of hair follicle, which contributes to a freer discharge of sebum. The second mechanism of action of this drug - this is a strong anti-inflammatory effect, which is realized by inhibiting the migration of leukocytes to the site of inflammation, as well as inhibition of the metabolism of arachidonic acid.
Adapalene and mometasone furoate: treatment regimen for alopecia areata
Recent studies have shown that the combination of the corticosteroid cream mometasone furoate and the synthetic retinoid adapalene is more effective in treating alopecia areata than mometasone alone. This scheme helps to reduce the size of the lesions, and also helps prevent the emergence of new lesions. The efficacy and safety of the use of this combination of drugs has been confirmed. The use of adapalene in the complex therapy of alopecia areata can be a major breakthrough in the treatment of this disease.
Possible side effects of adapalene
Adapalene should not be given to patients with inflammatory skin changes such as seborrheic dermatitis or eczema as this drug may increase irritation.
During the treatment of alopecia areata with adapalene, the patient should avoid any contact with the sun in order not to provoke the development of a hypersensitivity reaction.
Adapalene is strictly prohibited for use by children under twelve years of age, as well as by pregnant women, due to its embryotoxic effect. When the first signs of intolerance to the drug appear, it is necessary to stop using it.
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