Hyperpigmentation – a common problem with which patients turn to a cosmetologist. The appearance of dark spots on areas of the skin can be associated with a number of reasons, including hormonal disorders, skin reaction to trauma or cosmetic procedures, medications, etc. But most often hyperpigmentation in patients with European skin type (I – Fitzpatrick phototype IV) results from UV damage to the skin in the absence of proper sun protection. Especially for the treatment of diffuse hyperpigmentation in such patients, the line ME LINE CAUCASIAN SKIN (INNOAESTHETICS, Spain) from the official distributor TOTISPHARMA GROUP was created. The protocol of the procedure is given in the article estet-portal.com.
- Cosmetological correction of hyperpigmentation: mechanisms of action
- Fitzpatrick Type I–IV Hyperpigmentation Treatment Protocol
- Active ingredients and mechanism of action of ME LINE preparations CAUCASIAN SKIN
Cosmetological correction of hyperpigmentation: mechanisms of action
For hyperpigmentation therapy to be as effective as possible, it is necessary to influence the three main mechanisms affecting skin pigmentation:
- melanosome biogenesis and maturation;
- pigment maturation in mature melanosomes;
- migration of mature melanosomes to keratinocytes.
The more stages of hyperpigmentation we can block, the more effective and long-lasting the result will be.
The patient will not have to repeat the procedures of brightening professional peels often, and the result can be maintained with the help of home care.
As part of the cosmetic correction of hyperpigmentation, it is advisable:
- Providing reliable skin protection against aggressive UV exposure;
- use of antioxidants;
- reduction in melanin production;
- deep moisturizing;
- exfoliation of the stratum corneum of the skin.
All these tasks are effectively performed by the ME LINE CAUCASIAN SKIN line from the famous Spanish brand INNOAESTHETICS, designed specifically for skin phototypes I – Fitzpatrick IV.
Fitzpatrick Type I–IV Hyperpigmentation Treatment Protocol (H2)
Hyperpigmentation therapy protocol for European patients:
I. Skin preparation:
- Cleanse and degrease the skin, removing traces of cosmetics and sebum.
- Apply 1 layer of ME LINE 00PREP to the face with a cotton swab. Leave on for 3 minutes before applying ME LINE 01 CAUCASIAN SKIN.
II. Application 01 ME LINE CAUCASIAN SKIN MASK:
- Apply ME LINE 01 CAUCASIAN SKIN evenly over entire face.
- After a 15 minute exposure, apply a second coat exclusively on areas of hyperpigmentation:
- first session: leave for 30–45 minutes;
- second session: leave for 45–60 minutes (after 20 days);
- third session: leave for 30 minutes (after 6 months).
3. Clean and remove with a damp towel and Gentle Foam.
4. Finish with ME LINE 01 RESTORE + ME LINE 01 MOIST.
III. Post-peel treatment
- first 3–7 days use only ME LINE 03 RESTORE + MOIST and ME LINE 04 BB foundation;
- From day 4-8 start applying ME LINE 02 CAUCASIAN SKIN DAY CREAM + 03 and 04 + ME LINE 02 CAUCASIAN SKIN NIGHT CREAM all over the face. Use home care for for 1–2 months.
Active ingredients and mechanism of action of ME LINE CAUCASIAN SKIN preparations
– facial cleanser to enhance and optimize the results of ME LINE treatments
Active Ingredients and Their Effects:dexpanthenol – regulates the function of the epidermal barrier;
- bisabolol – prevents inflammation;
- L-Aspartate – contributes to the production of energy;
- magnesium – increases cell turnover and helps inhibit melanogenesis;
- copper – maintains skin integrity and removes toxins;
- gluconic acid – enhances cellular respiration;
- zinc – an antioxidant that repairs cellular DNA.
- The active ingredients in the ME LINE line act at all stages of pigmentation formation: they prevent melanin synthesis, they act during and after melanin synthesis.
ME LINE 00:
PREP (for professional use): skin conditioning solution used before treatment to increase the bioavailability of active ingredients for get the best effect.
Active ingredients: lactobionic, lactic, ferulic, thioctic acids, nonapeptide-1. In the case of dermal pigmentation, the targeted effect on the pigment in the dermis is possible thanks to the injectable preparation ME LINE ID
Ingredients act on melanin deposits and disperse pigment, as well as suppress inflammation.
Active ingredients: tranexamic acid, glutathione, ascorbic acid, naicinamide, magnesium gluconate, phenylalanine, leucine.
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ME LINE 01: CAUCASIAN SKINActive Ingredients and Their Action:
azelaic acid – inhibits tyrosinase, blocks mitochondrial redox systems;
- tranexamic acid – inhibits plasminogen and inactivates tyrosinase;
- arbutin – inhibits polymerase activity and maturation of melanosomes;
- kojic acid – blocks the conversion of DOPA to DOPA-quinone, prevents the transformation of DOPAquinone to eumelanin;
- lactobionic acid – prevents the formation of free radicals and inhibits the activity of metalloproteinases, enhances the barrier function;
- retinal – enhances desquamation of epidermal cells, stimulating cell renewal; inhibits the transcription factor, preventing melanosome transport;
- phenylethyl resorcinol – depigmenting properties due to blocking
- tyrosinase oxidation, inhibiting mRNA expression.
skin brightening day cream
Active Ingredients and Their Action:mandelic acid – stimulates exfoliation of the stratum corneum, disperses melanin in the basal layer of the epidermis;
- lactobionic acid – prevents the formation of free radicals and inhibits the activity of metalloproteinases, enhances the barrier function;
- phytic acid – works at the stage of melanin presynthesis, carries out chelation of copper and iron in the active part of the enzyme;
- kojic acid – blocks the conversion of DOPA to DOPAquinone, prevents the transformation of DOPAquinone to eumelanin;
- glutathione – inhibits the transport of tyrosine to premelanosomes;
- tranexamic acid – inhibits plasminogen and inactivates tyrosinase;
- GHK copper tripeptide – neutralizes free radicals.
Active Ingredients and Action:
azelaic acid – inhibits tyrosinase, blocks mitochondrial redox systems;
- melanostatin-5 – prevents the interaction of melanocyte-stimulating hormone
- with melanocyte receptors; arbutin – inhibits polymerase activity and maturation of melanosomes;
- magnesium sulfate – inhibits the activity of melanotropin;
- thioctic acid – inhibits metabolites on the way of conversion of DOPAquinone to indole;
- phenylethyl resorcinol – depigmenting properties due to blocking
- tyrosinase oxidation, inhibiting mRNA expression via PPARs receptors; retinal – enhances desquamation of epidermal cells, stimulating cell renewal;
Mechanism of action
: the combination of active substances prevents the recurrence of hyperpigmentation. They reduce inflammation and prevent any possible changes in the melanocyte caused by oxidation processes. Used for 10 days or more after a professional ME LINE treatment.
Active Ingredients: Red-brown Rosehip, Aloe Vera, Arnica, Centnella Asiatica, Glycyrrhetinic Acid. You may also be interested in:
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ME LINE 03: Moist – home care serumA gentle serum that contains highly concentrated hyaluronic acid, which creates a protective film on the surface of the epidermis, thus preventing skin moisture loss.
Ingredients
: hyaluronic acid, proteoglycans, allantoin, panthenol.
ME LINE 04: BB Cream Light, Medium – BB cream (two shades)gives skin freshness;
- visibly tightens pores;
- reduces redness;
- relieves irritation;
- moisturizes the skin;
- protects against UV rays;
- can be used as a makeup base.
Pospiling mask is used at home to optimize and improve the results of depigmentation therapy.
Composition
: almond acid 15%, azelaic acid 10%, phytic acid 10%, lactobionic acid 5%, lactic acid 5%, tranexamic acid 3%, salicylic acid 2%, retinal, Na hyaluronate, tocopherol. Benefits and proven efficacy of ME LINE for the treatment of hyperpigmentation
Clinical study results show resolution of mild melasma in 30.5% of patients treated with ME LINE for 4 weeks and in more than half of patients (57.9%) after 12 weeks.
Read also:
Melasma on European type skin: treatment protocol for all stages of melanogenesis Similarly, the percentage of moderate melasma decreased from 48.4% of patients to 8.4% at the end of the recommended three-month course of therapy. After 12 weeks of ME LINE therapy, all cases of severe hyperpigmentation were eliminated.
Results of ME LINE therapy: 15 days after 1 treatment – 45% improvement, after a month – 70%, one month after 2 treatments – 95% improvement.
ME LINE Benefits:
high efficacy and safety of drugs, confirmed by clinical studies;
- Innoaesthetics specialized laboratory, advanced equipment, innovative developments;
- European quality (manufactured in Spain);
- professional formulations with powerful, targeted action on hyperpigmentation therapy;
- Synergistic action of products within each therapeutic line;
- clear protocols for the use of ME LINE products (professional products + home care products);
- appreciable result already after 2 procedures, complete removal of age spots after 3 months of course treatment;
- The possibility of daily use of home care products that provide effective hydration and prevent photoaging of the skin.
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