Aesthetic medicine – This is one of the most sought after medical fields. Every day, hundreds of thousands of people around the world turn to specialists in aesthetic medicine, wanting to improve their appearance and keep their youth for as long as possible. That is why modern aesthetic medicine is developing so progressively, and one of its last outstanding achievements is the appearance on the market of effective tissue-specific drugs.
In an exclusive interview for estet-portal.com, a dermatologist, cosmetologist at the ADASSA medical center Tatyana Alexandrovna Epifantseva spoke about the main advantages and unique possibilities of using tissue-specific preparations in aesthetic medicine.
What are tissue-specific preparations, and for what purposes can they be used in aesthetic medicine?
Tissue-specific drugs are drugs that can affect metabolism, growth and division processes, have a regulatory effect on the function of various cells and, accordingly, organs and systems of the human body. EMET™ tissue-specific preparations are injectable peptide preparations of the ABG Lab line, USA. Mesovarton (Meso-Wharton P199) and Mezoxanthin (Meso-Xanthin F199) – for skin, MesoSculpt (MesoSculpt C71) – for adipose tissue, Mesoay (MesoEye C71) – for the microcirculation system. Each of these drugs serves a different purpose, and is designed with the known causes of aging and damage in mind, as well as the regulatory and metabolic processes of the tissue it is intended for.
What are the important features of the use of tissue-specific drugs?
An important feature of the use of a particular tissue-specific drug is understanding which process or system in the skin (epidermis, dermis, hypodermis, microcirculation) we want to influence, and how this or that peptide selectively exerts this effect. Let's look at the example of the injectable drug of the ABG Lab Meso-Wharton P199 line. Wharton Jelly Peptide P199, which is part of it, has the ability to activate the work of its own tissue-specific stem cells of the skin, which are called basal keratinocytes and mesenchymal stem cells, resulting in the formation of a "new", "young" skin. pool of keratinocytes and fibroblasts – the most important components of the epidermis and dermis. This is not just an activation of the division of fibroblasts already existing in the dermis, which have a limited number of divisions and their ability to divide can be exhausted. This is an opportunity to give a new "birth" skin and get a lasting and significant effect of rejuvenation.
What opportunities does the stimulation of skin mesenchymal stem cells with the P199 peptide, researched and proven on the basis of the Institute of Gerontology of the Academy of Medical Sciences of Ukraine in 2017, offer?
We all know that "youth" organism depends on the processes of renewal and cell division. However, our body is programmed for aging and death.
In 1961, the Hayflick effect was discovered – this is a limited number of cell divisions (with each division, the length of DNA telomeres decreases), after which the cell, exhausting its capabilities, dies.
If such cells are stimulated to divide, for example, fibroblasts in cosmetology, this can provoke undesirable effects or simply the absence of the desired effect. Therefore, modern cosmetology has turned its attention to tissue-specific mesenchymal stem cells of the skin, which are capable of an unlimited number of mitoses, and are able to give rise to "new" ones. cells of the epidermis and dermis with new potential for "healthy" divisions.
What results can be achieved by stimulating skin mesenchymal stem cells?
Stimulation of mesenchymal stem cells can start the processes of renewal of the cellular composition of the dermis and, as a result, the extracellular matrix. Peptide P 199 in the composition of the injectable cosmetic preparation Meso-Wharton P199 acts as a mobilization factor for the skin's own stem cells, activates their proliferation and differentiation into young functioning cells & nbsp; - keratinocytes and fibroblasts, while not having a stimulating effect on the "aging" or "damaged" cells.
What effects can be expected from the use of tissue-specific drugs?
Meso-Wharton P199 – treatment and prevention of age-related changes in the skin, eliminates cellular aging and restores the structure of the intercellular matrix by activating tissue-specific skin stem cells, cytokines and growth factors that regulate the activity of these stem cells. The effect of the course, consisting of 4 procedures, comes & nbsp; after a minimum of 4 weeks, and lasts up to 12 months.
Meso-Xanthin F199 – treatment and prevention of the so-called "damage" skin, "protection" cells from "damage", eliminates chronic inflammation caused by ultraviolet radiation, which has arisen in the process of various dermatological diseases (acne, rosacea), and also maintains the stability of the DNA nucleotide sequence. Fucoxanthin, which is part of the drug, has an epigenetic effect on inflammation processes, reduces the production of melanin by melanocytes and manifestations of vasodilation, which is clinically manifested in the "alignment" skin color and the elimination of dyschromia. The effect of treatment during the course of therapy, consisting,
Mesoeye C71 – treatment of aesthetic problems in the area around the eyes: puffiness, dark circles, wrinkles, the initial stage of the formation of periorbital hernias. Tissue-specific peptides, which are part of the injectable preparation, for the first time competently affect all three links of the microcirculation system. Periorbital Peptide XP2 relieves vasospasm, restores collagen fibers and protects against glycation, while Hexapeptide-17 eliminates vascular permeability and restores their tone, has a direct lymphostimulating effect. The effect of treatment during the course of therapy, consisting, depending on the problem, of 2-4 procedures, is observed after the first injection of the drug, and lasts for 4-6 days. months.
MesoSculpt C71 – correction of altered contours and oval of the face: "jumped", nasolabial "rollers", "bags" on the cheekbones, "second" chin. The drug was created directly for the correction of changes occurring in the superficial fat packs of the face and neck. Thanks to the unique components, MesoSculpt C 71 has an effective multi-vector effect on adipose tissue cells and microcirculation, physiologically reducing the volume: a pronounced lipo-reducing effect is achieved while maintaining the vital activity of fat cells, at the same time, the formation of new fat cells is controlled and their increase in size is controlled, which leads to to a long-term aesthetic effect. The unique direct lymphostimulating effect helps to restore hemodynamics in the superficial fat packs of the face and neck, and eliminates swelling. The effect of treatment during the course of therapy, consisting of 2-4 procedures, depending on the desired effect of volume reduction, is observed after the first injection of the drug, and lasts for 12 months.
What determines the choice of "profile" patient and why is it so important?Each drug has a specific effect to be expected, and which will logically manifest itself, given the mechanism of action of the main ingredient that is part of the drug.
The patient should be selected taking into account which processes and which layer of the face can be affected by the selected drug or combination of drugs.For example, an aged patient, but with manifestations of various dermatological processes on the face (for example, acne or rosacea), complex therapy should begin with an anti-inflammatory and With what "pitfalls" can a doctor encounter when using tissue-specific drugs?
Incorrect "diagnosis" for each change in each layer of the face and, as a result, incorrectly chosen treatment tactics using drugs from the ABG Lab line, USA, lead to the absence of the desired result and even the appearance of undesirable effects.
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