Meso-Radiesse is a promising method of using calcium hydroxyapatite to improve the condition of the skin of the face and body

The condition of the skin of the face, its quality largely depends on the condition of dermal collagen and elastin. A decrease in the quantity and quality of these fibers as structural elements of the dermis contributes to the manifestation of age-related changes – reduction in skin volume, deterioration of its elasticity, the appearance of wrinkles. In the treatment of aging skin, dermal fillers are considered effective, which replenish lost volumes and stimulate regenerative processes in skin structures. Estet-portal.com  considered the possibilities of long-term skin rejuvenation using Meso-Radiesse from the company Merz Aesthetics — a promising author's method of using calcium hydroxyapatite.

The Mechanism of Skin Rejuvenation with Radiesse in Large Dilutions

Filler based on calcium hydroxyapatite Radiesse^TM has been widely used as a means to replenish facial volume lost due to age-related changes and lifting. However, recent studies have shown that the anti-aging effect after the administration of the drug occurs not only because it corrects the contour of the face – the use of Radiesse^TM improves the quality of the skin of the face and body, stimulating neocollagenogenesis and angiogenesis, thereby increasing the thickness of the skin, its elasticity, restoring normal color.

I would like to dwell on the third effect of Radiesse — improving skin quality.  One study examining the potential of Radiesse^TM at high dilutions (1:2 and 1:8) was about how the skin reacts to injection 4 and 9 months after filler injection: the inflammatory skin response, collagen levels, a cell proliferation marker, and the presence of angiogenesis. The evaluation was carried out in comparison with a filler based on hyaluronic acid: first, RadiesseTM and a filler based on hyaluronic acid were compared, and then we continued to observe how the skin reacts to the use of RadiesseTM in dilution (Yutskovskaya Ya., Kogan E., Leshunov E. Randomized, split- face, histomorphological comparative study of a volumetric filler based on calcium hydroxyapatite and a dermal filler based on hyaluronic acid. J Drugs Dermatol. 2014; 13(9): 1047-52).

Neocollagenesis. 4 months after the Radiesse^TM injection procedure, the formation of collagen types 1 and 3 increased, and in the group using Radiesse^TM, type 3 collagen prevailed, and in the group that received the filler with hyaluronic acid – 1st type. At the control check after 9 months, the results have changed – in the group treated with Radiesse^TM, the formation of type 1 collagen was significantly higher, and in the group of HA – type 3 collagen predominated.

Thus, neocollagenesis induced by calcium hydroxyapatite preparation Radiesse^TM is a two-step process that is more consistent with physiological remodeling of the extracellular matrix.

Elastin.  Histomorphological examination showed an increased content of preserved perivascular elastic fibers both 4 and 9 months after the introduction of the filler Radiesse^TM.

Cell proliferation and angiogenesis. Expression of cell proliferation marker  4 months after the control injection of two fillers – based on hyaluronic acid and based on calcium hydroxyapatite – was approximately the same, but after 9 months – significantly higher in the Radiesse^TM group. In addition, more pronounced angiogenesis was observed in this group.

The stimulation of new capillary networks is especially important for getting the right amount of nutrients into the skin, and Radiesse^TM provides this process in the best way.

It should be noted that the inflammatory response, the degree of lymphohistiocytic infiltration and mucoid edema in the group of patients treated with Radiesse^TM injections were significantly lower than in the group treated with hyaluronic acid filler – both 4 and 9 months after the procedure.

New possibilities of Meso-Radiesse technique for improving skin quality

The mechanism of stimulation of neocollagenogenesis by calcium hydroxyapatite microspheres has been successfully used for an innovative method of skin reinforcement with Radiesse in high dilutions. This technique  used to improve the quality of the skin of the face and other areas of the skin of the body. In order to get only the stimulation of new collagen production, it is necessary to dilute the preparation with saline in various proportions in order to reduce its viscosity and elasticity and thus remove its volumetric properties and not get the effect of overcorrection.

Due to the conducted studies of the properties of the filler based on calcium hydroxyapatite, it was for the first time statistically proven that injections of Radiesse^TM stimulate collagen synthesis even when the drug is diluted, and this process is not accompanied by an inflammatory reaction of the skin. The synthesis of collagen fibers is accompanied by favorable remodeling of the entire extracellular matrix – with increased vascularization and increased synthesis of elastin. Patients note a significant improvement in the color and texture of the skin, a visual increase in its elasticity, and the disappearance of fine wrinkles.

Thus, in addition to the immediate correction of wrinkles and volume replenishment, injections of filler based on calcium hydroxyapatite Radiesse^TM start the processes of regeneration of skin structures much stronger than hyaluronic acid, which contributes to a long-term improvement in the quality of the skin of both the face and any other parts of the body.

Expert Anastasia Saibel's comment: We can perform classical reinforcement or vector lifting technique using Radiesse in those areas where the skin is quite dense. And if the skin is thin, it is better to use the Meso-Radiesse technique "according to Yutskovskaya". If vector lifting techniques are aimed at restoring the elastin-collagen skeleton according to the necessary vectors and thereby achieving first a delicate volumization, and then strengthening the supporting effect and enhancing the lifting, then with the help of Meso-Radiesse, we can, first of all, significantly improve leather quality.

Additional properties: Radiesse^TM  by Merz Aesthetics is highly effective in Meso techniques to restore the quality of the dermis. This is not only the skin of the face and neck, but also the skin of the abdomen, where, for example, postpartum recovery and elimination of the consequences of overstretching of the skin, the skin of the inner thighs and shoulders, the fold in the armpit area, the skin around the knees and elbows.