Scientists started talking about epigenetics about 100 years ago, using this term to describe various environmental factors that affect the development and life of our body, but do not interfere with the genetic structure of DNA.
Today, in aesthetic medicine, epigenetic factors are spoken of when they find a way to influence the cells of the skin and other tissues, the processes of their interaction, taking into account the genetic factors of heredity or in addition to them. In particular, the epigenetic potential of Meso-XanthinТМ F199 from EmetTM makes it possible to both specifically prevent skin aging and significantly improve its condition through anti-inflammatory and high antioxidant action, which consists in stimulating its own antioxidant systems. Read more about the possibilities of the drug and its scope on estet-portal.com.
How to slow down skin aging in terms of epigenetics
Skin aging is a gradually progressive process when the number of cells decreases and their functional activity weakens, and all these processes are programmed by DNA and accelerated under the influence of harmful environmental factors such as: ultraviolet solar radiation, smoking, alcohol, various inflammatory skin diseases and many other causes.
The consequence of this is an increase in destructive processes in the matrix of the dermis, a progressive decrease in its main components. Outwardly, the result of destructive processes is manifested by the loss of skin elasticity and the ability to quickly restore shape, flabbiness, dryness, thinning and other signs characteristic of aging.
At the cellular level, skin aging processes are caused by a gradual decrease in the number of functionally active fibroblasts and their ability to divide, in addition, the expression of genes encoding the synthesis of peptides that ensure the interaction of the dermal matrix and fibroblasts decreases, thereby reducing the synthetic activity of the latter.
The functions of these proteins are closely related to the proliferation and differentiation of keratinocytes, the synthesis of elastin and collagen, and the maintenance of glycosaminoglycans and their ability to retain water. In the process of involutional changes, the amount of proteins in the epidermis and dermis gradually decreases, the ability to replicate DNA and restore its damaged areas decreases.
You can prevent conditions that cause skin aging by due to epigenetic mechanisms that trigger the synthetic activity of fibroblasts and prevent damage from environmental factors and inflammation
The central link in the chain, bilateral interaction of fibroblasts with the extracellular matrix, are functionally significant peptides - integrins. Epigenetically enhance the expression of the genes responsible for the synthesis of these important proteins, Meso-XanthinTM F199 from EmetTM.
Epigenetic therapy: how to slow down skin aging and improve its appearance
The epigenetic activity of Meso-XanthinТМ F199 is primarily responsible for the carotenoid fucoxanthin, obtained by a special technology from brown algae. The therapeutic effect of Meso-XanthinTM F199 is associated with the ability to increase gene expression of functionally significant peptides – integrins, which play a key role in bilateral interactions between fibroblasts and the extracellular matrix, determining the proliferative and synthetic activity of cells. This effect allows you to restore the normal process of collagen formation.
The second important mechanism is the ability to remove the damaging effects of inflammatory reactions. According to research by Japanese scientist Dr. Hiroshi Shimoda, fucoxanthin has an epigenetic effect on the synthesis of COX2 (an inflammatory mediator) and blocks p75 neutrophil receptors.
The third important mechanism is protection. Fucoxanthin is a powerful antioxidant from the group of carotenoids, protects body cells from ultraviolet radiation, binds free radicals, preventing lipid peroxidation, preventing cell destruction, damage to the DNA structure and early skin aging. Unlike many other antioxidants, it is able to stimulate the body's own antioxidant system through Nrf2 factor playing an extraordinary role in the regulation of & nbsp; antioxidant processes in skin cells and other organs and systems.
It is able to repair the DNA of skin cells without changing their gene structure, which contributes to the proper functioning of cells and reduces the risk of accumulation of errors and defects in the process of subsequent division. Carotenoid F199 has the following properties:
- maintains the integrity and stability of cell DNA under various stress conditions;
- normalizes the synthesis of its own collagen and elastin;
- regulates cellular metabolism;
- has an anti-inflammatory effect.
High molecular weight hyaluronic acid in Meso-XanthinТМ F199 strengthens the extracellular matrix, ensures the delivery and circulation of signal protein molecules that trigger neocollagenogenesis.
Synthetic recombinant growth factors are important components of the drug that slow down skin aging:
- epidermal – activates cellular reproduction of keratinocytes;
- insulin-like – stimulates intracellular metabolism and production of structural components of the matrix;
- fibroblast growth factor – enhances cell regeneration and microcirculation processes.
Through the action of the injectable medical preparation Meso-XanthinTM F199 from EmetTM. a powerful antioxidant effect is manifested, an epigenetic effect on inflammation and collagen formation due to which the visual rejuvenating effect is significantly prolonged. Patients note & nbsp; improvement of skin tone and elasticity, the severity of vascular manifestations softens, the skin acquires a radiant appearance, the manifestation of pigmentation decreases.
Share:
Add a comment