Biological peeling of a new generation: cellular stimulation without negative effects on the skin

When working with patients, doctors often focus on lifting procedures and aesthetic manipulations that drastically change the face, paying little attention to skin quality. This approach is ineffective, because the unsatisfactory appearance of the skin can negate all the efforts of a specialist. Therefore, when working with patients of all age categories, it is important to find the golden mean between injection, hardware and care procedures, as well as to be able to correctly combine them in order to obtain the best correction results. Maria Shirshakova – Candidate of Medical Sciences, Dermatovenereologist, Cosmetologist, Associate Professor of the Department of General Medicine GOU DPO RMAPO MH and SR, The aging process and related factors

• How to stimulate tissues and cells to prevent aging
• Inno Exfo MCA 35 – new generation biorevitalizing peel
• Protocol for the procedure using peeling Inno Exfo ISA 35
• Combination of Inno Exfo MCA 35 peeling with other cosmetology
• procedures The aging process and related factors The process of internal aging is continuous and usually begins after 20 years of age. It is associated with:

Telomere shortening

1. Telomeres protect the ends of chromosomes from shortening during DNA replication. Shortening of telomeres leads to the termination of the cell cycle and apoptosis, and, according to some data, plays a key role in the process of cellular aging. It is now known that telomere shortening – one of the answers to the photo is stress-induced aging. Therefore, aesthetic therapy should be positive, since the distress syndrome associated with the difficult rehabilitation of the patient will lead to increased aging.

Mitochondrial damage

2. The role of mitochondria in the aging process is complex – aging and accumulation of damage to mitochondria leads to the development of oxidative stress, contributing to the shortening of telomeres and cellular aging.

Endocrine changes

3. Hormone production decreases with age. Lower levels of estrogen lead to thinning of the skin, a decrease in its moisture-retaining properties, changes in elasticity and vascularity, and an increase in pigmentation. Subscribe to our channel in

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The pathogenesis of aging:

Atrophoderma (dermatoporosis):

thinning of the epidermis;
thinning of the dermis (loss of collagen, elastin and hyaluronic acid).

Change by PFA and SMAS:

activity of mimic muscles;
remodeling and redistribution of PFA.

Volume changes:

age-related change in the oval of the face (morphological changes);
atrophy of adipose, muscle and bone tissues;

displacement of ligaments.
• When carrying out biorevitalization procedures, an additional intake of antioxidants will be beneficial, which protect the skin and have a preventive effect on photoinduced aging.
• External factors, in particular solar radiation, also contribute to the aging process and may contribute to the appearance of signs of premature aging:

focal hyperpigmentation;

focal depigmentation;

loss of tone and elasticity;
increased fragility of the skin;
benign and malignant tumors.
• Histopathological examination of skin with signs of photoaging reveals elastosis, epidermal atrophy, and changes in collagen and elastin fibers. In skin with very pronounced signs of photoaging, fragmented, thickened and less structured collagen fibers are found.
• The clinical manifestations of age-related changes in the skin are most pronounced on the skin of the face, neck and hands, which are most exposed to external aging factors.

Appearance of the skin during internal aging:

relatively unchanged, remains smooth; appearance of individual mimic wrinkles.

Skin with combined external and internal aging:

wrinkled; with areas of hypo- and hyperpigmentation;

tone and elasticity decreased, brittleness increased;
purpura.
• In addition, fatty tissue enters the skin, and the superficial end sections of the muscles are also woven into it. All these structures interact with
fibroblasts
• – "factory" that synthesizes the elements of the extracellular matrix.

With age, the previously stellate structure of the fibroblast turns into a round one, and the cells themselves become incapable of producing collagen and elastin fibers – essential proteins of youth.

Skin loses its ability to renew itself.

How to stimulate tissues and cells to prevent their aging

Restoration of skin density refers to the phenomenon of transformation and adaptation of space to accommodate new structures. To achieve this, need to consistently stimulate

:

cells; cellular structures;

molecules;
matrix.
Types of Dermal Density Restoration:

physical (light, lasers, currents, ultrasound); chemical (peelings, active ingredients, complexes);

mechanical (needles, cannulas, crystals, vacuum);
biological (cells, growth factors, markers).
• Due to positive and negative stimulation, hydration, tone, blood flow, pigment and other types of metabolism, cellular respiration improve. As a result, the surface of the skin is leveled, it becomes healthy, well-groomed and radiant.
• Often we combine the ways of exposure and resort to combined individual biological stimulation of the dermis, in which
biorevitalizing peeling

Innoaesthetics

Inno Exfo MCA 35 from the official distributor of TOTISPHARMA GROUP LLC.  

 Exfo

ISA 35

– the latest development of the Spanish laboratory INNOAESTHETICS, which has already become a bestseller – peeling with a biorevitalizing effect to reduce the signs of photoaging: elastosis, wrinkles and  atrophic skin. Inno Exfo MCA 35 – new generation biorevitalizing peel If earlier biorevitalization meant injections of unmodified HA, then today this concept has become broader:

Skin revitalization due to stimulation of renewal processes;

during the procedure, important regenerative processes in cells and tissues are stimulated;

main goal – restoration of the microenvironment and cellular activity.

The same goes for peels, which are no longer considered solely exfoliators. New generation peelings – they are also biological activators, stimulants, normalizers and regulators of cell functions.
Restoration of local tissue homeostasis is achieved due to
• skin response system to stress
, which triggers the synthesis of very important components:

corticotropin-releasing hormone: involved in the stimulation or suppression of cell proliferation and inflammation;

MSH and ACTH: stimulates melanin synthesis, anti-inflammatory activity and proliferation of keratinocytes;

beta-endorphins: stimulate the proliferation of keratinocytes and fibroblasts, enhance the barrier function of the skin.

Due to perfectly balanced components
• innovative biorevitalizing peeling
• Inno

Exfo

MCA 35 acts as follows: breaks connections between superficial corneocytes; stimulates cell renewal by exfoliating epidermal cells;

stimulates keratinocytes and fibroblasts to repair the basement membrane;

• stimulates fibroblasts to produce extracellular matrix components.
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Effect after peeling Inno Exfo MCA 35:

brightness and skin lightening; normalization of skin blood flow;

homogeneity and thinning of the stratum corneum;

• thickening of the epidermis;
• decrease in the number of pigmented keratinocytes;
• an increase in the number of collagen fibers of type IV basement membrane;
• an increase in the number of type I and III collagen fibers in the dermis;
• increase in dermal thickness;
• smoothness and uniformity of the skin;
• increased turgor and skin hydration;
• increased elasticity;
• wrinkle depth reduction;
• even skin tone.
Advantages of MCA 35 over analogues: peeling does not have a negative effect on the skin, is very well tolerated, gives excellent results without a rehabilitation period and is suitable for patients of different age categories.
• Smart

GPS

® (

Guidance Performance System) – a special system that delivers all the active ingredients of cosmetic preparations to the necessary layers of the skin, imitating the physico-chemical characteristics of the upper layers of the skin and without violating their integrity. Thanks to Smart GPS® all Inno Exfo MCA 35 peeling components are maximally bioavailable and effective! Peeling is indicated: for photoaging, involutional skin changes or for their prevention, and can also be used as a preparation for other cosmetic procedures. Read also:

Case studies of Full

Face technique for correcting age-related changes in patients with different types of aging Peel composition Inno Exfo

ISA 35: monochloroacetic acid (35%) – starts the processes of intensive revitalization and restructuring of the skin, without causing a rough keratolytic effect and does not require long-term rehabilitation. This makes the procedure less traumatic and minimizes discomfort;

arbutin (10%)

– responsible for the fight against hyperpigmentation and skin lightening, as the safest, plant analogue of hydroquinone, arbutin inhibits tyrosinase, normalizes melanin biosynthesis and prevents further violations of this process;
• salicylic acid (7%)
– has an exfoliating effect, stimulates the renewal of skin cells, providing a long-term result, and evens out the skin relief, reduces hyperkeratosis not only on the surface of the skin, but also in the mouths of the follicles, improving the outflow of sebum;
• hyaluronic acid – provides deep tissue hydration, helps to reduce the depth of wrinkles, restores youthfulness and elasticity of the skin;
• magnesium gluconate – an essential trace element that takes part in the cellular energy cycle (ATP production).
•  

Inno

Exfo ISA 35

– is a unique drug for the treatment of involutional skin changes. The low molecular weight allows the peeling to easily penetrate into the deeper layers of the skin, effectively stimulate the work of fibroblasts and start the process of neocollagenesis. Peeling normalizes the state of the epidermal barrier, improves corneometry, that is, skin hydration, and increases the index of microcirculation efficiency. The epidermis becomes more homogeneous, the structure of the dermis becomes more  dense. 
Protocol of the procedure using Inno Exfo MCA 35 peeling The Inno Exfo MCA 35 procedure is very simple and fast: Skin is cleansed with a mild cleanser Inno-Derma Soft Cleanser.

The skin is degreased with a special agent 

Degreasing Solution

.

2.5 ml of peeling is applied to the face: for this, it is necessary to put on gloves and apply 1-2 layers with massage movements. Peeling can also be applied with gauze or cotton applicator.
1. Without neutralizing or washing off the peeling with water, Skin Repair Cream is applied to the skin.
Finally, the skin is covered with a sunscreen
2. INNO-DERMA Sunblock SPF 50+.
Hyperpigmentation protocol:
5. Pre-Peel Preparation:
Use Inno-Derma Dark Spot Eraser or Age Rescue C 21-30 days prior to treatment, at night. Stop using Inno-Derma Cream 24-48 hours before peeling

.

Peeling:

1. 1st treatment cycle: 4 treatments every 10 days;
2nd treatment cycle: 2 treatments every 21 days.

Post-peel care:

start using Inno-Derma Dark Spot Eraser or Age Rescue C 5 days after the procedure. Continue using for 12 weeks after the procedure.
• Maintenance Treatments: 

 

every 10 months
3. .
4. Combination of Inno Exfo MCA 35 peeling with other cosmetic procedures For patients with deformation type of age-related changes, who have oily but dehydrated skin and a tendency to fluid retention, the combination is excellent
th

Inno

Exfo МСА 35 and a drug based on non-stabilized HA in one procedure. This approach will not lead to increased puffiness and will provide: increase skin hydration; normalization of sebum secretion. What can be combined with

Inno
Exfo
ISA 35:

wrinkles of the upper third of the face (in combination with BTA and CP); pasture wrinkles (reinforcement techniques + peels and CP); wrinkles of the lower third of the face (in combination with peels and CP, to a lesser extent – BTA); neck and décolleté wrinkles, as an option (possible using the filling technique).

• Inno Exfo MCA 35 biorevitalization procedure can be performed after
ultrasonic peeling
• in one procedure
,
• and massage techniques and cosmetic care can be used between procedures.
• Combination of
chemical peeling and HA biorevitalization procedure:

We can do peeling and biorevitalization of HA in one procedure, as a single protocol, or Peeling and 2 biorevitalization procedures in a week

Combination of mesotherapy and

bio

peelings:
• At the end of the course of lipolytic mesotherapy, 2–4 procedures of biorevitalization of HA + peeling are performed, or they should be alternated with lipolytics with an interval of 1 week.

Photos of Inno Exfo

MCA 35 after 4 treatments:

 

 

you can perform a peeling procedure, in a week to inject botulinum toxin, in another week – peeling.

Plastic surgery and contouring:

it is better to have a course of peelings before the CT, or, if the CT has already been done, then peeling can be done in a week;
preparation for plastic surgery is also shown – take a course of peelings, as good skin quality contributes to a quick recovery;

Peeling procedure is prescribed not earlier than 1 month after plastic surgery: course 3–4 procedures.

Inno Exfo MCA 35 peeling works great as a preparation for plastic surgery, as good skin quality will speed up rehabilitation.

Laser resurfacing, phototherapy and peeling:
The course of preparation for laser resurfacing and photorejuvenation consists of 2 peeling biorevitalization procedures with a 2-week interval between them;

rehabilitation of patients after the use of a laser or photosystem begins after complete restoration of the skin, the course of rehabilitation – 3–4 procedures once a month.

The procedure of cellular biostimulation with Inno Exfo MCA 35 peeling corresponds to the principles of prevention in the 5P system – personalized preventive evidence-based predictive positive aesthetic therapy.

• Possibilities of acid peeling for the face in correcting persistent pigmentation

The modern patient has high requirements for aesthetic manipulations, wants to get an instant result, positive emotions and no rehabilitation.

Cell biostimulation procedure – not just an exit procedure, but also a positive procedure within the 5P system, which gives amazing results with a high degree of patient satisfaction and loyalty.

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