It is generally accepted that botulinum toxin preparations are susceptible to diffusion. In this regard, numerous studies are being conducted, many of which dispute the clinical significance of this phenomenon.
However, aesthetic medicine professionals who have encountered the undesirable effects of toxin diffusion will not agree with this scientific opinion.
After all, diffusion does not always depend only on the dose of the drug and the depth of injection, and sometimes it can occur under the influence of other factors, more about which you can read on estet-portal.com in this article.
Botulinum Toxin Diffusion: Why the Drug Diffusion Occurs
The material was written on the recommendations of the doctor, head of the clinic Doctor Helga Olga Belogorskaya.
Distribution of neurotoxin solution – it is a physical process, which is primarily influenced by the anatomical and histological structure of the tissue into which the drug is injected.
Factors that may be expected to influence the diffusion of botulinum toxin include:
• protein composition of botulinum toxin;
• dose of injected botulinum toxin;
• concentration of the botulinum toxin preparation;
• volume of neurotoxin solution;
• needle size;
• injection speed;
• target muscle localization;
• the presence of tissue damage at the injection site;
• muscle contraction after injection.
The precision of injection into specific target muscles, along with the use of properly sized doses of botulinum toxin, allows the specialist to achieve excellent results with minimal risk of adverse events.
Botulinum toxin: why poison has no analogues among drugs
Influence of complexing proteins on the diffusion of botulinum toxin
The extremely correct experimental study regarding the diffusion of botulinum toxin was carried out by the experts of
The reconstituted neurotoxin solution, ready for use, contains the already free form of botulinum toxin.
However, despite the fact that botulinum toxin serotypes are structurally and functionally similar, there are specific differences in the effects of different types of neurotoxin on neurons. In this regard, during the procedure, it is necessary to build on the properties inherent in each specific drug, and follow the instructions.
Injection technique is also known to affect the diffusion of botulinum toxin. Too large a diameter of the needle, and a high rate of injection of the drug can cause injury to the target muscle tissue. As a result, the absorption of the toxin in the target area will be reduced, as a result of which its spread to nearby areas will increase.
Thus, to prevent this unwanted side effect, additional monitoring methods, such as electromyography, can be used to help improve the accuracy of the injection.
For more useful information about botulinum toxin
read inTelegram! Basic methods for controlling the diffusion of botulinum toxin
Diffusion of botulinum toxin – this phenomenon is inevitable, however, amenable to control. First, it must be remembered that different botulinum toxin preparations have different diffusion characteristics. In this regard, the required concentration and volume of the injected drug for each type of botulinum toxin is different.
When using the correct dose of
Botox®, the doctor may not be afraid of the side effects associated with the spread of the drug, since in this case the diffusion processes can be completely control.Allegan original products You can only purchase from an authorized distributor.
See also:
Basic methods for evaluating the effect of botulinum toxin preparations
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