Preparations containing type A botulism toxin have firmly entered our lives and are widely used for both medical and aesthetic indications. The family of these drugs is expanding, new drugs are registered based on the same active substance, which do not differ much from each other, but allow the cosmetologist and his patient to choose the most appropriate remedy for solving a particular problem.
One of the differences between different preparations of botulinum toxin, which the doctor must be aware of, is the storage conditions of the preparation. Usually they are quite rigid, and if they are not followed, then botulinum toxin injections will be ineffective.
The drug Xeomin, which appeared on our market, has certain advantages in this regard, which you can read about on estet-portal.com.
What can influence the stability of a botulinum toxin injection
Botulinum toxin preparations, despite their similarity in terms of the main active substance, have quite significant differences, which relate, among other things, to the chemical composition. In order to preserve the specific activity of botulinum toxin, it is combined in the preparation with non-toxic complexing proteins. These specific proteins (immunoglobulins, glycoproteins, albumins) do not allow the destruction of the active substance of the neurotoxin and have the ability to glue, bind particles of the substance with tissue cells, helping the action of the active substance of the drug.
When the drug is injected, the neurotoxin is concentrated in the region of the nerve endings of a particular tissue (usually striated muscles, smooth muscles, sweat glands), blocking the release of acetylcholine through the synaptic cleft. In this case, the complexing proteins are separated from the neurotoxin, the passage of the impulse is blocked, the muscle relaxes. After some time, the accumulated botulinum toxin is metabolized and excreted from the body.
The complexing proteins that keep the neurotoxin stable when it penetrates the tissues can only perform their functions at certain temperatures. It is assumed that the importance of carefully observing the storage conditions of drugs is associated with this condition. For some, this is necessarily a freezer, for others, just a refrigerator is enough, and after dilution, the preparations retain their shelf life only for 1-4 hours.
In the production of Xeomin, it was possible to avoid the destruction of the active substance without the participation of complexing proteins, therefore the drug contains only neurotoxin and, therefore, according to the researchers, does not depend on temperature fluctuations
The activity of pure neurotoxin in Xeomin is identical to other drugs in this group, but it begins to act faster.
Read also: "Botulinum toxin Xeomin in Ukraine: what problems will the drug help to solve"
What are the advantages of botulinum toxin injection when there is no dependence on temperature
The production technology of the drug Xeomin from «Merz Aesthetics» assumes the preservation of its active and stable form, when the botulinum toxin substance that is not combined with complexing proteins is stored, it will not lose its effectiveness and safety when high temperatures.
Complex studies of the drug Xeomin showed that the neurotoxin in its composition is active for 30 days at a temperature of 60 degrees. And even at 70 degrees Xeomin remains stable for 3 days
In the finished dosage form, Xeomin remains stable at room temperature for 3 years and retains activity even for 4 years. When asked how long Xeomin can be stored after reconstitution, experts answer that it is possible for 24 hours at a temperature not higher than 4 degrees - to avoid problems with sterility.
The fact that Xeomin does not require freezing and storage under special conditions, while maintaining its stability at sufficiently high temperatures, is especially valuable for doctors in summertime, when the drug delivery can be associated with long periods.
Regardless of the conscientiousness of suppliers and couriers, delays at customs or traffic jams, the doctor can be absolutely sure that the drug will be effective, achieve the planned result of the procedure, and at the same time remain absolutely safe for the patient.
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