Hyaluronic acid is present in almost all tissues of the body. The highest concentration of hyaluronic acid in the human body is found in the extracellular matrix of the connective tissue. Hyaluronic acid plays a particularly important role in the synovial fluid of the joints, the dermis of the skin and the vitreous body of the eye. Due to its high molecular weight and ability to retain large amounts of water, the leading functions of hyaluronic acid in the body lie in its structural and hydration capacity.
Find out in the article on estet-portal.com what mechanisms ensure the stability of hyaluronic acid in tissues, slowing down the process of its splitting by tissue enzymes.
- Hyaluronic acid and cellular activity
- Hyaluronic acid degradation process
- RRS HA LONG LASTING – a product with the properties of a filler and a biorevitalizant
Hyaluronic acid and cellular activity
Hyaluronic acid acts as a shock absorber, provides the necessary level of moisture and stability of the extracellular space, in which cells, in particular fibroblasts, as well as components of the extracellular matrix, such as collagen and elastin fibers, are reliably supported, which creates volume for skin tissues, playing the role of its framework.
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It has been established and confirmed that hyaluronic acid is also involved in cellular activity, including regulation, migration and adhesion, including skin fibroblasts, the main sources of collagen and elastin. High molecular weight hyaluronic acid exhibits anti-angiogenic and anti-inflammatory properties, while low molecular weight fragments (< 100 kDa) have the opposite biological activity.
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They exhibit slight inflammatory, immunostimulating and angiogenic properties, which ensures high-quality skin renewal. Many authors report: when analyzing the functions of hyaluronic acid and its fragments, it was established that they are directly involved in
It is well known that the half-life of hyaluronic acid after injection into the skin and joints is no more than 24 hours,
since hyaluronic acid is naturally degraded in the body by a complex enzymatic mechanism involving hyaluronidase enzymes (Hyal), as well as the processes of hyaluronic acid capture by cells using CD44 receptors on the surface of the cell membrane.
It is assumed that the degradation of HA is a highly organized and strictly controlled process.
The breakdown of hyaluronic acid into fragments with a precisely defined size to ensure their biological function is realized by the following enzymes - hyaluronidase-1 and hyaluronidase-2, which are most widely expressed by connective tissue cells. Recent studies have shown that hyaluronic acid can also be naturally degraded in the body by reactive oxygen species (ROS).
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1) high biocompatibility; 2) resistance to enzyme systems, both tissue and plasma (for injectable formulations).
3) the ability to form into various forms (gels, films, etc.);
4) the ability to be sterilized chemically or physically without changing the structure of the product.
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! Today, BDDE is used for most of the cross-linked hyaluronic acid hydrogels currently on the market. Besides easy synthesis, HA-BDDE uncoupling products have not shown cytotoxicity, and epoxy compounds are hydrolyzed to simple diols. Benefits of BDDE (1,4-Butanediol Diglycidyl Ether):
- Proven safety, - Over 25 years of market experience,
- Present in 95% of the used cross-linked HA fillers
«Academy of Scientific Beauty»
presents a unique drug RRS HA LONG LASTING, which was developed using UnHeatIng technology. This new technological process for the formation of hyaluronic acid hydrogel works at the moment of a chemical cross-linking reaction. This process slows down the breakdown of the newly formed cross-linked hyaluronic acid in the tissues under the influence of enzymes, which prolongs the effect of the procedure. Read also: Hyaluronic acid safety and crosslinker concentration: determining the relationship
RRS HA LONG LASTING contains a residual amount of BDDE at a dose of less than 2ppm, which meets the international safety standard. In addition to drug stability, UnHeatIng technology provides
preservation of high molecular weight with specified rheological parameters in a 3 ml syringe volume with a total content of cross-linked hyaluronic acid 21mg. RRS HA LONG LASTING – product with filler and biorevitalizant properties RRS HA LONG LASTING – this is the first hybrid product with the properties of a filler and a biorevitalizant.
This product has the following benefits for the beautician when working with it:
- The preparation has modeling properties due to the high plasticity of the gel, -
The use ofRRS HA LONG LASTING is recommended for both the mid and
deep dermis depending on skin density. - Possibility of injecting the gel into the projections of zones of physiological age-related depression of the facial skeleton, or into zones that are targets for a certain morphotype of aging, - Sufficient syringe volume - 3 ml, guarantees the possibility of a complete procedure with maximum coverage of areas with a long-term effect and minimal risk of adverse events.
Cellular mechanisms of regulation of the process of skin renewal
In addition to hyaluronic acid, RRS HA LONG LASTING contains unique components - osmolyte and an amino acid cluster. Osmolite effectively eliminates post-implantation microtraumas, and the amino acid cluster protects the hyaluronic acid chains from the process of uncoupling and additionally
is a source of "building material" for the synthesis of elastin and collagen. The most effective hybrid drug RRS HA LONG LASTING, presented by by the Academy of Scientific Beauty
, has proven itself in the treatment of actinic elastosis of the skin, photoaging and correction of age wrinkles, as well as with hypersensitivity, a tendency to damage and pigmentation disorders. RRS HA LONG LASTING – this is a prolonged skin revitalization with elements of volumetric correction, which the doctor can successfully combine with other procedures and minimal risks of side effects.
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