Hyaluronic acid (HA), a natural polysaccharide used in the manufacture of dermal fillers for aesthetic medicine needs. Because the half-life is several days in human tissue, hyaluronic acid dermal filler is chemically modified to increase its lifespan in the body. The most common modification used in commercial HA filler is the crosslinking of HA chains using 1,4-butanediol diglycidyl ether (BDDE) as the crosslinker.
Find out in the article on estet-portal.com about the methods of modifying hyaluronic acid, as well as about which stitching technology is the safest and most effective.
- Skin regeneration under the influence of hyaluronic acid
- Chemical structure of hyaluronic acid chains
- Skin injury as a factor in enhancing degradation of hyaluronic acid
Skin regeneration under the influence of hyaluronic acid
Hyaluronic acid (HA) based fillers are the most common and popular dermal fillers used in the field of aesthetic medicine.
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Such dermal fillers are hydrogels, typically consisting of > 95% water and 0.5–3% hyaluronic acid, giving them a gel-like character. structure. Hyaluronic acid is a polysaccharide that is one of the main components of the extracellular matrix of connective tissue in the human body.
Read also: Hydrolifting: reinforcement and biorevitalization in one procedure
Its widespread use is explained as a biologically inert component, which is found in all tissues, and as a special anti-inflammatory and reparative properties. Normally in the skin, oxidative stress occurs due to reactive oxygen species (ROS), which can originate from both external factors and endogenous factors. In particular, in vitro tests have been carried out to evaluate the antioxidant activity of hyaluronic acid.
Human keratinocytes have been treated with oxygen peroxide or exposed to ultraviolet A radiation to enhance the lipid peroxidation process. As a result, the positive effect of reparative processes was observed even at the minimum concentration of hyaluronic acid (0.92 mg / ml) in preparations that were used to restore
Hyaluronic acid consists of a repeating disaccharide unit (1,4)-glucuronic acid-b(1,3)-N-acetylglucosamine (GlcNAc) linked by glycosidic bonds.
This structure of hyaluronic acid is absolutely identical for all tissues and extracellular structures. This property makes hyaluronic acid a highly biocompatiblemolecule compared to some protein-based fillers such as collagen.
Global rejuvenation: contouring of the middle third of the face Such protein excipients may have an amino acid sequence heterogeneity that is recognized by the patient's immune system and causes hypersensitivity reactions
both immediate and delayed cellular reactions associated with rejection of the foreign protein.
Facebook! Today, the main limitation in the use of hyaluronic acid as a dermal filler is the
rapid exchange of acid in tissues, which is due to the presence of a specific family of enzymes called hyaluronidases. So far, several chemical modifications have been described in the structure of hyaluronic acid in order to increase its half-life in tissues. Most of these modifications attempt to reduce the access of hyaluronidases to the polysaccharide polymer by crosslinking the hyaluronic acid chains. Thus, cross-linked HA hydrogels form products that are more resistant to enzymatic degradation than native hyaluronic acid due to the formation of bridges and intermolecular covalent bonds between the HA structure and the crosslinking agent.<
Technique for effectively removing forehead wrinklesThe most popular chemical crosslinkers used to make crosslinked hyaluronic acid include methacrylamide, hydrazide, carbodiimide, divinyl sulfone, 1,4-butanediol diglycidyl ether (BDDE), and poly(ethylene glycol) diglycidyl ether. It is BDDE that is the most commonly used crosslinking agent. While these types of hydrogels have been shown to be safe for decades, the crosslinkers used are reactive
agents that can be cytotoxic and, in some cases, mutagenic. As a result, their residual presence in the final hydrogel must be carefully controlled, and in the case of BDDE, its residual concentration is considered safe when it is
The innovative product RRS HA LONG LASTING by «
Academy of Scientific Beauty»uses a unique CO-DELIVERY technology that allows it to contain cross-linked hyaluronic acid with a total concentration of 21 mg, to improve turgor and elasticity, achieve optimal skin hydration and, as a result, improve the appearance with elements of volumetric modeling. This is the first hybrid product with filler and biorevitalization properties.
The cross-linking process used in the production of RRS HA LONG LASTING –is a new technique for the formation of hyaluronic acid hydrogel at the time of the chemical cross-linking reaction, which prevents the newly formed cross-linked hyaluronic acid from rapidly disintegrating in tissues and minimizes the use of cross-linking agents.The concentration of residual or unreacted BDDE in the product is within the safety standard and minimizes the risk of developing
Injury to the skin as a factor in enhancing the degradation of hyaluronic acid Also, RRS
HA
LONG LASTING contains a protective complex: (did not understand what was meant) SUGGESTED: protective a buffer containing 15 amino acids, as well as osmolyte. Osmolyte is designed to eliminate the effects of skin injury during injections, which also reduces the synthesis of the hyaluronidase enzyme, since the process of damage and local inflammation is trigger in relation to the transcription of this enzyme and thus may enhance the degradation of hyaluronic acid.
Therefore, it is osmolyte that can protect HA molecules from decay in tissues from the first day of the procedure. The amino acid cluster is aimed at tissue repair and serves as a depot for the synthesis of skin matrix proteins such as elastin and collagen.
Rules for the prevention of side effects of facial skin peeling
Indications for the use of RRS HA LONG LASTING by "Academy of Scientific Beauty"
are - skin photoaging, dermal atrophy, tissue volume deficiency, as well as pathologies associated with pigment pigment disorders. metabolism and keratinization process: lentigo/freckles, actinic elastosis, diffuse hyperpigmentation, mottled pigmentation, guttate hypomelanosis, reticular seborrheic keratosis, telangiectasias, venous vascular spots.Read also: Premature skin aging: how to slow down the degradation of collagen and elastin
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