How does the condition of the skin depend on the work of growth factors

Как зависит состояние кожи от работы факторов роста

The discovery and isolation of growth factors was not in vain awarded the Nobel Prize in Physiology or Medicine. These compounds have already proven their effectiveness in the treatment of cardiovascular, hematological and oncological diseases. And today, growth factors are successfully used in aesthetic medicine. Their influence on the manifestation of age-related changes, on improving the condition of the skin is difficult to overestimate. Scientists continue to explore the possibilities of growth factors in the correction of skin defects. Learn more about this estet-portal.com.

Skin Condition and Growth Factors: What is Dependence

Growth factors are active biological compounds, peptide or steroid hormones. They can work as signaling molecules, carrying out interaction between cells. For example, one cell secretes growth factors that interact with the receptors of another nearby cell and trigger certain reactions there. These or other growth factors can produce any cell in the body. General functions of growth factors:

regulate the growth and reproduction of cells;
trigger the transformation of unspecialized cells into specialized cells
support the health of all tissues and organs.

Skin cells are also capable of producing growth factors. Their biological task is to regenerate the skin, start the synthesis of collagen and elastin fibers, and ensure the elastic and elastic state of the skin.

Growth factors are able to slow down the aging process to a certain extent, reduce the manifestations of age-related skin changes, and this has been proven by many scientific studies.

Thanks to the use of growth factors in aesthetic medicine, it is possible to slow down the processes of thinning of the dermis, reduce the loss of collagen and damage to elastin. They are also able to influence some external changes that have occurred with the skin under the influence of ultraviolet radiation and other adverse factors. Growth factors can help repair damaged capillaries, reduce skin dryness, and even out complexion.

My default image

Growth factors that can affect the condition of the skin

Different growth factors in the skin are synergistic, and if one of them is activated, its action will stimulate the activity of others.

Some growth factors and their functions

Name	Where is synthesized	Why you need it
Epidermal Growth Factor (EGF)	Epithelial cells, macrophages and fibroblasts	Stimulates cell growth and division, epidermal renewal
Transforming growth factor alpha (TGF-alpha)	Macrophages, fibroblasts, epithelium	Similar to epidermal growth factor and initiates angiogenesis
Transforming growth factor beta (TGF-beta)	Macrophages, T-lymphocytes, endotheliocytes, platelets, thymic epithelium	Actively catalyzes fibrogenesis acts as a chemoattractant for fibroblasts, promotes collagen synthesis
Transforming Growth Factor (a-NGF)	Fibroblasts	Actively affects angiogenesis
Platelet Growth Factor	Platelet alpha granules, macrophages, fibroblasts, smooth muscle cells, endothelium	Stimulates proliferation and protein synthesis in target cells, has a pro-inflammatory effect, promotes collagen synthesis
Fibroblast growth factor (primary) (bFGF)	Nervous tissue and pituitary	Actively stimulates the proliferation of all cells of the vascular wall
Fibroblast growth factor (acidic) (FGF)	Activated macrophages and T-lymphocytes	Responsible for the synthesis of angiogenesis factor
Keratinocyte Growth Factor (KGF)	Epidermis cells	Growth factor, accelerates epithelialization and wound healing

Not a single growth factor alone can create the effect of real rejuvenation, improve skin condition. Together, they trigger a cascade of rejuvenating biochemical reactions. But in order for them to bring the expected effect, the skin must have certain reserves. Therefore, the use of products with growth factors should be included in the skin care program along with nourishing and moisturizing products.